Results 281 to 290 of about 110,473 (315)

Poly(ADP-ribose) polymerases: managing genome stability

The International Journal of Biochemistry & Cell Biology, 2005
The importance of poly(ADP-ribose) metabolism in the maintenance of genomic integrity following genotoxic stress has long been firmly established. Poly(ADP-ribose) polymerase-1 (PARP-1) and its catabolic counterpart, poly(ADP-ribose) glycohydrolase (PARG) play major roles in the modulation of cell responses to genotoxic stress.
Mirella L, Meyer-Ficca, Ralph G, Meyer, Elaine L, Jacobson, Myron K, Jacobson   +3 more
openaire   +2 more sources

Interaction of poly(ADP-ribose)polymerase with DNA polymerase ?

Molecular and Cellular Biochemistry, 1994
Homogeneously purified poly(ADP-ribose) polymerase (PARP) specifically stimulated the activity of immunoaffinity-purified calf or human DNA polymerase alpha by about 6 to 60-fold. Apparently, poly(ADP-ribosyl)ation of DNA polymerase alpha was not necessary for the stimulation.
S, Yoshida, C M, Simbulan
openaire   +2 more sources

Activity Assays for Poly-ADP Ribose Polymerase

2004
Poly(ADP-ribose) polymerase (PARP-1) is a nuclear enzyme that has traditionally been thought to require discontinuous or "damaged" DNA (dcDNA) as a coenzyme, a preconception that has limited research mainly to its role in cell pathology, i.e., DNA repair and apoptosis.
Eva, Kirsten, Ernest, Kun, Jerome, Mendeleyev, Charles P, Ordahl   +3 more
openaire   +2 more sources

Detection of poly(ADP-ribose) polymerase and its reaction product poly(ADP-ribose) by immunocytochemistry

The Histochemical Journal, 1996
Poly(ADP-ribose) polymerase catalyses the formation of ADP-ribose polymers covalently attached to various nuclear proteins, using NAD+ as substrate. The activity of this enzyme is strongly stimulated upon binding to DNA single or double strand breaks. Poly(ADP-ribosyl)ation is an immediate cellular response to DNA damage and is thought to be involved ...
J H, Küpper, L, van Gool, M, Müller, A, Bürkle   +3 more
openaire   +2 more sources

Poly(ADP-ribose) polymerase and aging

2001
Publisher Summary Poly(ADP-ribose) polymerase (PARP) is a major nuclear protein associated with chromatin that contains zinc fingers and binds to either double- or single-strand DNA breaks. Upon binding to DNA, PARP is activated and forms covalent homopolymers of poly(ADP-ribose) (PAR) attached to a number of nuclear proteins, including itself and ...
Dean S. Rosenthal, Cynthia M. Simbulan-Rosenthal, Wen Fang Liu, Mark E. Smulson   +3 more
openaire   +1 more source

Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression

Nature Reviews Molecular Cell Biology, 2021
Lori Anne Passmore, Jeff Coller
exaly  

Poly(ADP-Ribose) Polymerase

2023
openaire   +1 more source

Poly(ADP-ribose) Polymerase

2011
openaire   +2 more sources

Poly (ADP-Ribose) Polymerase

2008
openaire   +2 more sources

Poly(ADP-ribose) polymerase inhibition: past, present and future

Nature Reviews Drug Discovery, 2020
Nicola J Curtin, Csaba Szabo
exaly