Results 161 to 170 of about 2,253,495 (194)

In Vitro Hydrolytic Degradation of Hydroxyl-Functionalized Poly(α-hydroxy acid)s

Biomacromolecules, 2007
The in vitro hydrolytic degradation of hydroxyl-functionalized poly(alpha-hydroxy acid)s was investigated. Benzyl-ether-protected hydroxyl-functionalized dilactones (S)-3-benzyloxymethyl-(S)-6-methyl-1,4-dioxane-2,5-dione (1a) and (S)-3-benzyloxymethyl-1,4-dioxane-2,5-dione (1b) were copolymerized in a melt with various amounts of L-lactide using ...
Leemhuis, M., Kruijtzer, J.A.W., van Nostrum, C.F., Hennink, W.E.   +3 more
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Biodegradable poly(α‐hydroxy acid) polymer scaffolds for bone tissue engineering

Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2010
AbstractSynthetic graft materials are emerging as a viable alternative to autogenous bone graft and bone allograft for the treatment of critical‐sized bone defects. These materials can be osteoconductive but are rarely intrinsically osteogenic, although this can be greatly enhanced by the application of bone morphogenetic proteins (BMPs).
Nicole Y C, Yu, Aaron, Schindeler, David G, Little, Andrew J, Ruys   +3 more
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In vivo degradation of massive poly(α-hydroxy acids): Validation of In vitro findings

Biomaterials, 1992
The degradation of various high-molecular-weight aliphatic polyesters derived from glycolic acid and/or lactic acid enantiomers was previously investigated in vitro. It was demonstrated that the bulk degradation mechanism proposed in the literature actually proceeds heterogeneously and proceeds faster in the centre than at the surface of large ...
M, Therin, P, Christel, S, Li, H, Garreau, M, Vert   +4 more
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Surface perspectives in the biomedical applications of poly(α-hydroxy acid)s and their associated copolymers

Analytical and Bioanalytical Chemistry, 2002
Impressive advances in biotechnology, bioengineering, and biomaterials with unique properties have led to increased interest in polymers and other novel materials in biological and biomedical research and development over the past two decades. Although biomaterials have already made an enormous impact in biomedical research and clinical practice, there
Joo-Woon, Lee, Joseph A, Gardella
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Fabrication of poly(α‐hydroxy acid) foam scaffolds using multiple solvent systems

Journal of Biomedical Materials Research, 2001
AbstractThe present studies describe the fabrication and characterization of highly porous and interconnected poly(α‐hydroxy acid) foam scaffolds produced using a phase separation multisolvent system, followed by a sublimation process. Fabrication parameters, including solvent composition, polymer concentration, freezing temperature, polymer type, and ...
Yunhua, Hu, David W, Grainger, Shelley R, Winn, Jeffrey O, Hollinger   +3 more
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Bone-derived growth factor release from poly(α-hydroxy acid) implants in vitro

Biomaterials, 1993
Matrix proteins were extracted from bovine cortical bone and polymer implant discs (13 mm x 2 mm composed of 50:50 poly DL-lactide-co-glycolide; mol. wt. approximately 9000) prepared by compression moulding granules with lyophilized bone matrix extracts (BMX) 10.1 (w/w).
M C, Meikle, W Y, Mak, S, Papaioannou, E H, Davies, N, Mordan, J J, Reynolds   +5 more
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Surface characterization of poly(α-hydroxy acid) microspheres prepared by a solvent evaporation/ extraction process

Biomaterials, 1997
This work constitutes the first attempt to characterize the wettability of poly(alpha-hydroxy acid) (PAHA) microspheres in situ, prepared according to a complex process involving emulsification, solvent evaporation, washing and freeze-drying. The analysis of the flotation profile of the microspheres has allowed us to determine both advancing and ...
F, Boury, H, Marchais, J P, Benoit, J E, Proust   +3 more
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Ring-opening polymerization of 3(S)-[(benzyloxycarbonyl)methyl]-1,4-dioxane-2,5-dione: a new route to a poly(.alpha.-hydroxy acid) with pendant carboxyl groups

Macromolecules, 1988
Obtention d'un copolymere alterne forme d'unites acide glycolique et α-(S)-malate de ...
Yohiharu Kimura, Kenji Shirotani, Hideki Yamane, Toshio Kitao   +3 more
openaire   +1 more source

Functionalized Poly(α-hydroxy acid)s via Ring-Opening Polymerization:  Toward Hydrophilic Polyesters with Pendant Hydroxyl Groups

Macromolecules, 2006
Two functionalized dilactones with protected hydroxyl groups, benzyloxymethyl methyl glycolide (4a) and benzyloxymethyl glycolide (4b), were synthesized and converted to the corresponding polyesters by ring-opening polymerization in the melt (at 110 °C using benzyl alcohol and SnOct2 as initiator and catalyst, respectively, and at 130 °C using SnOct2 ...
Leemhuis, M., van Nostrum, F., Kruijtzer, J.A.W., Zhong, Zhiyuan, ten Breteler, M.R., Dijkstra, Pieter J., Feijen, Jan, Hennink, W.E.   +7 more
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Porous morphology, porosity, mechanical properties of poly(α‐hydroxy acid)–tricalcium phosphate composite scaffolds fabricated by low‐temperature deposition

Journal of Biomedical Materials Research Part A, 2007
AbstractTissue engineering is expected to construct complicated hominine organs composed of many different types of cells. One of the key points is the accurate controlling of scaffold material and porous morphology point by point. A new direct rapid prototyping process called low‐temperature deposition manufacturing (LDM) was proposed to fabricate ...
Li, Liu, Zhuo, Xiong, Yongnian, Yan, Yunyu, Hu, Renji, Zhang, Shenguo, Wang   +5 more
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