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Facile Procedure for Generating Side Chain Functionalized Poly(α-hydroxy acid) Copolymers from Aldehydes via a Versatile Passerini-Type Condensation

Organic Letters, 2010
A general method for synthesizing alpha-hydroxy N-acylindoles in one-pot via an acid-catalyzed condensation of a convertible isonitrile with water and various aldehydes is presented. These intermediates were incorporated into poly(alpha-hydroxy acid) copolymers bearing residues with functionalizable side chains, which could be further modified through ...
Mark, Rubinshtein   +6 more
openaire   +2 more sources

An approach to the design of a particulate system for oral protein delivery. I.In vitrostability of various poly (α-hydroxy acids)-microspheres in simulated gastrointestinal fluids

Journal of Microencapsulation, 2008
The stability of various biodegradable polyester polymers with different molecular weights and lactic/glycolic acids ratios were evaluated in simulated gastrointestinal fluids as an approach to apply microparticles for oral protein delivery on the basis of particle uptake mechanism.
Nastaran, Nafissi-Varcheh   +2 more
openaire   +2 more sources

Biodegradable implants from poly-(alpha-hydroxy acid) polymers for isoniazid delivery.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 1999
In vitro and in vivo study of an isoniazid (INH) drug delivery system.To develop a system for the treatment of tuberculosis using a subcutaneous polymer implant with a large drug load released slowly over a long period. INH delivery by biodegradable poly-(alpha-hydroxy acid) polymers was evaluated using ground polymer and compression molded implants ...
L, Hurley, B R, Andersen
openaire   +1 more source

Synthesis of Terpineol from Alpha-Pinene Catalyzed by α-Hydroxy Acids

Molecules, 2022
Yonghong Zhou   +2 more
exaly  

Dual Effects of Alpha-Hydroxy Acids on the Skin

Molecules, 2018
Jen-Hung Yang, Sheau Chung Tang
exaly  

A versatile route to functionalized dilactones as monomers for the synthesis of poly(alpha-hydroxy) acids

European Journal of Organic Chemistry, 2003
Leemhuis, M.   +4 more
openaire   +1 more source

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