Results 101 to 110 of about 1,496,050 (296)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Red blood cell membrane-camouflaged nanoparticles loaded with AIEgen and Poly(I : C) for enhanced tumoral photodynamic-immunotherapy. [PDF]

Natl Sci Rev, 2021
Dai J, Wu M, Wang Q, Ding S, Dong X, Xue L, Zhu Q, Zhou J, Xia F, Wang S, Hong Y.   +10 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Synthesis and Application of Poly(N-isopropylacrylamide-co-methacrylic Acid) Hydrogels as Sorbent Materials for Wastewater Treatment

Separations
N-isopropylacrylamide and methacrylic acid were copolymerized by a free radical polymerized mechanism. The obtained hydrogel poly(N-isopropylacrylamide-co-methacrylic acid) hydrogels, poly(NIPAM-co-MAA), were utilized as sorbent material for removal Cr ...
Aleksandar Zdravković, Vesna Nikolić, Snežana Ilić-Stojanović, Sanja Stojanović, Ana Dinić, Maja Urošević, Ivana Gajić, Ljubiša Nikolić   +7 more
doaj   +1 more source

[Interferon production by various means of administering modified poly I-C].

Voprosy virusologii, 1982
Modified poly(I) . poly(C) induces appreciable amounts of interferon in Macaca rhesus monkeys not only after intravenous but also after intramuscular, endolumbar, and subconjunctival inoculations. The time course and intensity of interferon production after various routes of the induced inoculation were similar.
O G, Andzhaparidze, T A, Bektemirov, M P, Burgasova, K Ia, Ogleznev   +3 more
openaire   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Torsion and bending of nucleic acids studied by subnanosecond time-resolved fluorescence depolarization of intercalated dyes [PDF]

, 1982
Subnanosecond time‐resolved fluorescence depolarization has been used to monitor the reorientation of ethidium bromide intercalated in native DNA, synthetic polynucleotide complexes, and in supercoiled plasmid DNA.
Millar, D. P., Robbins, R. J., Zewail, A. H.   +2 more
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Both-Sided TOPCon Solar Cells – Towards a Lean Process Flow for Silicon Bottom Solar Cells

SiliconPV Conference Proceedings
Silicon solar cells with both-side full-area passivating hole and electron contacts are viable candidates for application as bottom cells in tandem architectures.
Johannes Seif, Jana-Isabelle Polzin, Mathias Bories, Martin Hermle, Martin Bivour   +4 more
doaj   +1 more source

Molecular Evaluation of the Therapeutic Potential of DNA-Based Vaccines Against Experimentally Induced Lung Cancer [PDF]

Journal of Bioscience and Applied Research
Lung cancer, or lung carcinoma, is a malignant lung tumor characterized by uncontrolled cell growth in lung tissue. In Egypt, it has high morbidity and mortality rates.
S. Hassab El-Nabi, Abdel Aziz Zidan, Nourhan El. Ghayesh, Karolin Abdel Aziz, EL Hassan Mokhamer   +4 more
doaj   +1 more source