Results 81 to 90 of about 1,496,050 (296)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
The influence of CD40 ligation and interferon-γ on functional properties of human monocyte-derived dendritic cells activated with polyinosinic-polycytidylic acid [PDF]
Vojnosanitetski Pregled, 2011 Background/Aim. Ligation of a Toll-like receptor (TLR) by specific TLR agonists is a powerful tool for maturation induction of monocyte-derived dendritic cells (MoDCs).
Dragičević Ana +7 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Determining the effect of organic and low-input production methods on food quality and safety. QLIF subproject 2: Effects of production methods [PDF]
, 2009 The objectives of QLIF subproject 2 were to: (i) identify the effect of production systems (organic, low-input and conventional) on food quality and safety parameters; (ii) identify agronomic parameters responsible for differences in food quality and ...
Leifert, C
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Three-Step Process for Efficient Solar Cells with Boron-Doped Passivated Contacts
EnergiesCrystalline silicon (c-Si) solar cells with passivation stacks consisting of a polycrystalline silicon (poly-Si) layer and a thin interfacial silicon dioxide (SiO2) layer show high conversion efficiencies.
Saman Sharbaf Kalaghichi +4 more
doaj +1 more source
Learning Coverage Functions and Private Release of Marginals [PDF]
, 2014 We study the problem of approximating and learning coverage functions. A function $c: 2^{[n]} \rightarrow \mathbf{R}^{+}$ is a coverage function, if there exists a universe $U$ with non-negative weights $w(u)$ for each $u \in U$ and subsets $A_1, A_2 ...
Feldman, Vitaly, Kothari, Pravesh
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Poly I∶C and R848 Induce Cell Proliferation in the Intact Rat Spinal Cord [PDF]
, 2008 目的研究Poly I∶C与R848对脊髓细胞增殖的诱导效应。方法大鼠单次腹腔注射(ip)Poly I∶C与R848,增殖的细胞由BrdU跟踪标记。结果Poly I∶C与R848可引起大鼠脊髓BrdU+细胞明显增加,于注射后2~3 d达最高,随后快速降至正常水平,同时可见BrdU+/Nestin+细胞存在,并伴小胶质细胞的活化,未见有ED-1+/BrdU+的细胞。地塞米松可抑制细胞增殖及小胶质细胞活化,而消炎痛无此作用。结论配体被TLR识别后可能参与脊髓内正常神经细胞的发生过程 ...
吕姝焱, 徐顺清, 苏艳华
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source