Results 71 to 80 of about 1,496,050 (296)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Selection of Reference Genes by Quantitative Real-Time PCR in Different Cell Lines from Humpback Grouper (Cromileptes altivelis)

Fishes
Humpback grouper (Cromileptes altivelis) is an economically important fish, but the increasing density of its farming has led to more severe disease outbreaks.
Xiangyu Du, Han Zhang, Longfei Zhu, Zhenjie Cao, Chen Zhang, Ying Wu, Yongcan Zhou, Yun Sun   +7 more
doaj   +1 more source

Improving mechanical properties for extrusion-based additive manufacturing of poly(lactic acid) by annealing and blending with poly(3-hydroxybutyrate) [PDF]

, 2019
Based on differential scanning calorimetry (DSC), X-ray diffraction (XRD) analysis, polarizing microscope (POM), and scanning electron microscopy (SEM) analysis, strategies to close the gap on applying conventional processing optimizations for the field ...
Cardon, Ludwig, D'hooge, Dagmar, Daelemans, Lode, De Clerck, Karen, Fiorio, Rudinei, Gou, Maling, Wang, Sisi   +6 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Synthesis of novel poly(dG)-poly(dG)-poly(dC) triplex structure by Klenow exo− fragment of DNA polymerase I [PDF]

, 2017
The extension of the G-strand of long (700 bp) poly(dG)-poly(dC) by the Klenow exo− fragment of DNA polymerase I yields a complete triplex structure of the H-DNA type.
Borovok, Natalia, Dwir, Benjamin, Kapon, Eli, Klinov, Dmitry, Kotlyar, Alexander, Molotsky, Tatiana   +5 more
core  

Thermoresponsive poly(2-oxazoline)s, polypeptoids, and polypeptides [PDF]

, 2017
This review covers the recent advances in the emerging field of thermoresponsive polyamides or polymeric amides, i.e., poly(2-oxazoline)s, polypeptoids, and polypeptides, with a specific focus on structure-thermoresponsive property relationships, self ...
Hoogenboom, Richard, Schlaad, Helmut
core   +2 more sources

Ivermectin improved behavioral and molecular deficits of poly I: C-Induced schizophrenia model in rats

Neuroscience Applied, 2023
Backrounds: Schizophrenia is a devastating psychiatric disorder with complex symptoms and neurobiology, affecting approximately 1% of the world's population. Studies have shown that exposure to viral and bacterial infections during pregnancy increases the risk of neurodevelopmental disorders including schizophrenia and autism  ...
Taşkıran, Sacide, Bozkurt, Nuh Mehmet, Ünal , Gökhan, Taşkıran, Mehmet   +3 more
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Toll-like receptor activation induces airway obstruction and hyperresponsiveness in guinea pigs

Respiratory Research
Background Microbial infections, particularly those caused by rhinovirus (RV) and respiratory syncytial virus (RSV), are major triggers for asthma exacerbations. These viruses activate toll-like receptors (TLRs), initiating an innate immune response.
Yujiao Xiang, Jielu Liu, Mu Nie, Gunnar Nilsson, Jesper Säfholm, Mikael Adner   +5 more
doaj   +1 more source

[Interferon induction in monkeys by poly I-C complex with poly-L-lysine].

Voprosy virusologii, 1977
The spectrum characteristics, the stability to pancreatic RN-ase and hydrolases of the monkey and mouse blood as well as interferon induction in mice and monkeys by poly I: poly C and its complex with poly-l-lysine were studied. The complex was found to be more stable to the treatments tested as well as markedly interferonogenically active in Macaca ...
T A, Bektemirov, M P, Burgasova, O G, Andzhaparidze   +2 more
openaire   +1 more source