Results 71 to 80 of about 39,772,641 (314)

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Toll-like receptor activation induces airway obstruction and hyperresponsiveness in guinea pigs

Respiratory Research
Background Microbial infections, particularly those caused by rhinovirus (RV) and respiratory syncytial virus (RSV), are major triggers for asthma exacerbations. These viruses activate toll-like receptors (TLRs), initiating an innate immune response.
Yujiao Xiang, Jielu Liu, Mu Nie, Gunnar Nilsson, Jesper Säfholm, Mikael Adner   +5 more
doaj   +1 more source

[Interferon induction in monkeys by poly I-C complex with poly-L-lysine].

Voprosy virusologii, 1977
The spectrum characteristics, the stability to pancreatic RN-ase and hydrolases of the monkey and mouse blood as well as interferon induction in mice and monkeys by poly I: poly C and its complex with poly-l-lysine were studied. The complex was found to be more stable to the treatments tested as well as markedly interferonogenically active in Macaca ...
T A, Bektemirov, M P, Burgasova, O G, Andzhaparidze   +2 more
openaire   +1 more source

Poly (I∶C) induces PKR activation, upregulates BACE1 and promotes Aß production.

, 2013
The viral dsRNA analog polyinosinic:polycytidylic acid [poly (I∶C)] activates PKR in MEF PERK−/− cells. Protein extracts obtained after 3 and 6 h of poly (I∶C) treatment were analysed by Western blotting using anti-BACE1, anti-phospho-PKR(T446), anti-PKR,
Francesc X. Guix (349265), Ernest Palomer (349259), Carmen Antúnez (349268), Luis M. Real (166765), Mònica Bosch-Morató (349263), Jordi Clarimón (5651836), José J. Galán (349267), Eva Ramos-Fernández (349262), César Fandos (349270), Marta Tajes (349264), Francisco J. Muñoz (349271), Ruth F. Itzhaki (342336), Matthew A. Wozniak (342329), Mercé Boada (349269), Gerard ILL-Raga (349258)   +14 more
core   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

The crucial role of RIG-I in upregulating neutrophil CXCR2 expression through the MAPK signaling pathway in viral pneumonia

Respiratory Research
Background Dysregulated neutrophilic inflammation is a hallmark of severe COVID-19, but the mechanisms driving human peripheral neutrophils (HPNs) recruitment remain incompletely defined. C-X-C motif chemokine receptor 2 (CXCR2), a key chemokine receptor
Yuxin Wang, Qi Shi, Yaxin Pan, Xiaoyu Sun, Huayang Wang, Yi Zhang   +5 more
doaj   +1 more source

IKK inhibitor reversed the IFN-β induction and virus replication suppression mediated by poly(I∶C) pretreatment.

, 2013
HepG2 cells were incubated in control or IKK inhibitor for 30 min before poly(I∶C) pretreatment and virus infection. (A) Cells were harvested for measurement of IFN-β expression level; (B) Immunofluorescence microscopy. Cells were fixed at 24 h p.i.
Li He (134049), Minhao Wu (346691), Siyu Wu (286775), Ping Zhang (86495), Lifang Jiang (115735), Yuye Li (286773), Lianqiang Feng (346693), Zhaoduan Liang (346687), Xi Huang (12172)   +8 more
core   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

The influence of CD40 ligation and interferon-γ on functional properties of human monocyte-derived dendritic cells activated with polyinosinic-polycytidylic acid [PDF]

Vojnosanitetski Pregled, 2011
Background/Aim. Ligation of a Toll-like receptor (TLR) by specific TLR agonists is a powerful tool for maturation induction of monocyte-derived dendritic cells (MoDCs).
Dragičević Ana, Džopalić Tanja, Vasilijić Saša, Vučević Dragana, Božić Biljana, Majstorović Ivana, Balint Bela, Čolić Miodrag   +7 more
doaj   +1 more source