Results 91 to 100 of about 39,772,641 (314)

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Crystallization and melting behaviour of poly (3-butylthiophene), poly (3-octylthiophene)and poly (3-dodecylthiophene)

, 2005
The crystallization and melting behavior of poly(3-butylthiophene) (P3BT), poly(3-octylthiophene) (P3OT), and poly(3-dodecylthiophene) (P3DDT) were studied. The equilibrium melting temperatures (Tm 0) of these polymers were measured and resulted equal to
VALENTINI, LUCA, Marigo A., Marega C., KENNY, Jose Maria, Causin V.   +4 more
core   +2 more sources

H&E staining of duodenal cross sections from mice treated with poly(I∶C) at 30 mg/kg (A), 15 mg/kg (B), or 0 mg/kg poly(I∶C) (C).

, 2013
Animals were sacrificed 9 h after poly(I∶C) administration, and their small intestines were harvested.
Laila Dafik (333762), Megan Albertelli (333763), Chaitan Khosla (24135), Ludvig M. Sollid (263515), Jorunn Stamnaes (333764)   +4 more
core   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Double labelling of poly(A) RNA and the U2B” protein in Lupinus (A–C) and Allium (D–F) root cells.

, 2014
Poly(A) RNA present within Cajal bodies stained an anti-U2B” antibody (arrows). Immunogold labelling of poly(A) RNA in the Cajal bodies (CBs) of Lupinus root cells. Gold particles were mainly observed in the Cajal body (CB) (G). Simultaneous localisation
Dariusz J. Smoliński (691731), Beata Kalich (698256), Ewa Kubicka (698255), Janusz Niedojadło (691728)   +3 more
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Red blood cell membrane-camouflaged nanoparticles loaded with AIEgen and Poly(I : C) for enhanced tumoral photodynamic-immunotherapy. [PDF]

Natl Sci Rev, 2021
Dai J, Wu M, Wang Q, Ding S, Dong X, Xue L, Zhu Q, Zhou J, Xia F, Wang S, Hong Y.   +10 more
europepmc   +1 more source

[Interferon production by various means of administering modified poly I-C].

Voprosy virusologii, 1982
Modified poly(I) . poly(C) induces appreciable amounts of interferon in Macaca rhesus monkeys not only after intravenous but also after intramuscular, endolumbar, and subconjunctival inoculations. The time course and intensity of interferon production after various routes of the induced inoculation were similar.
O G, Andzhaparidze, T A, Bektemirov, M P, Burgasova, K Ia, Ogleznev   +3 more
openaire   +1 more source

CpG-ODN and Poly (I: C)LL induce increased expression of IL-6 and IL-8.

, 2014
(A) End1/E6E7 cells were stimulated with CpG-ODN and poly (I: C)LL (10 µg/ml) for 6 hrs. Conditioned media was collected for quantification of IL-6 and IL-8 by ELISA.
Kudumula Venkata Rami Reddy (506311), Ameya Sathe (506310)   +1 more
core   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source