Results 51 to 60 of about 39,772,641 (314)

Aliphatic Diacidic Long-Chain C16 Polyesters from 10,16-Dihydroxyhexadecanoic Acid Obtained from Tomato Residual Wastes

Molecules, 2019
10,16-dihydroxyhexadecanoic acid obtained from agroresidual tomato waste, was oxidized to produce 7-oxohexadecanedioic acid in good yield (>70%) and purified without oxidation side products in one step.
Daniel Arrieta-Baez, José Vicente Hernández Ortíz, José Campos Terán, Eduardo Torres, Mayra Beatriz Gómez-Patiño   +4 more
doaj   +1 more source

Poly I: C-activated dendritic cells that were generated in CellGro for use in cancer immunotherapy trials [PDF]

Journal of Translational Medicine, 2011
Abstract Background For clinical applications, dendritic cells (DCs) need to be generated using GMP-approved reagents. In this study, we tested the characteristics of DCs generated in two clinical grade culture media and activated by three maturation stimuli, Poly I: C, LPS and the mixture of proinflammatory cytokines
Fučíková Jitka, Rožková Daniela, Ulčová Hana, Budinský Vít, Sochorová Klára, Pokorná Kateřina, Bartůňková Jiřina, Špíšek Radek   +7 more
openaire   +3 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

TLR3 Agonist Amplifies the Anti-Inflammatory Potency of ADSCs via IL-10-Mediated Macrophage Polarization in Acute Pancreatitis

Stem Cells International
The immunoregulatory role of mesenchymal stem cells (MSCs) in inflammation is heterogeneous and can exhibit anti-inflammatory or proinflammatory properties depending on the microenvironment. We herein observed that the activation of Toll-like receptor 3 (
Jianxing Liu, Wenjing Yan, Shanshan Chen, Yingjie Sun, Fangfang Zhang, Yue Yang, Liang Jin   +6 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Effect of Poly I:C on Experimental Respiratory Infection in Hamsters [PDF]

Applied Microbiology, 1970
The interferon inducer double-stranded polyinosinic acid and polycytidylic acid (poly I:C) was studied in hamsters experimentally infected with parainfluenza 3 virus. Upper intranasal, deep intranasal, or intraperitoneal treatment of hamsters with poly I:C (100 μg/100- to 120-g animal) 24 hr before an upper respiratory infection significantly reduced ...
openaire   +2 more sources

LTR insertion in TRPM1 causes premature poly-adenylation.

, 2013
(A) The 1378bp LTR insertion (ECA1g. 108,297,929_108,297,930 ins1378) is flanked by 6 bp regions of micro-homology which are highlighted in yellow. Poly-adenylation signal sequences are highlighted in green.
Martina Engensteiner (475385), Monika Reissmann (234862), Daniel Foerster (475381), Sulochana Devi (475378), Sheila Archer (475379), Bruce Grahn (475391), Michael J. Mienaltowski (475387), Johanna L. A. Paijmans (475389), Heather Holl (475377), Vijayasaradhi Setaluri (19642), Rebecca R. Bellone (316199), Lynne Sandmeyer (475380), Nityanand Maddodi (19640), Bianca Haase (81664), Ralf Bortfeldt (475382), George Forsyth (475386), Arne Ludwig (53733), Sim Lin Lim (475383), Gloria Gonzalez-Fortes (475390), Janelle Nelson (475384), Michael Hofreiter (2821), Melanie Pruvost (234855), David L. Adelson (110514), Tosso Leeb (81674), Samantha A. Brooks (171540), Padmanabhan Mahadevan (475388)   +25 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

PROTECTIVE EFFECT OF POLY I:C AGAINST SISOMICIN NEPHBOTOXICITY IN RABBITS [PDF]

Pediatric Research, 1980
The protective effect of Poly I:C during sisomicin nephrotoxicity in rabbits was determined by measurement of the urinary enzymes alkaline phosphatase (AF),lactic dehydrogenase (LDH) and N-a-cetyl-β-glycosaminidase(NAG). 18 rabbits were divided in 3 Groups.
ZEIS, PM, NACOPOULOU, L, GOURIOTIS, D, PIERROUTSAKOS, I, KOUKOUTSAKIS, P, POGAS, N, VLACHOS, P   +6 more
openaire   +2 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source