Results 41 to 50 of about 39,772,641 (314)

Combined Dietary Administration of Chlorella fusca and Ethanol-Inactivated Vibrio proteolyticus Modulates Intestinal Microbiota and Gene Expression in Chelon labrosus

Animals, 2023
The use of functional feeds in aquaculture is currently increasing. This study aimed to assess the combined impact of dietary green microalgae Chlorella fusca and ethanol-inactivated Vibrio proteolyticus DCF12.2 (CVP diet) on thick-lipped grey mullet ...
Jorge García-Márquez, Daniel Álvarez-Torres, Isabel M. Cerezo, Marta Domínguez-Maqueda, Félix L. Figueroa, Francisco Javier Alarcón, Gabriel Acién, Eduardo Martínez-Manzanares, Roberto T. Abdala-Díaz, Julia Béjar, Salvador Arijo   +10 more
doaj   +1 more source

Poly I∶C–induced stochastic IFNβ expression depends on the amounts of poly I∶C and MDA5.

, 2012
(A) IFNβ/YFP homozygous MEF cells were electroporated with Cy5-labeled poly I∶C, and FACS analysis was carried out 8 h after the electroporation to assay the strength of Cy5 and YFP.
Stefanie Scheu (63765), Tom Maniatis (66839), Mingwei Zhao (167087), Jiangwen Zhang (45394), Hemali Phatnani (187081)   +4 more
core   +1 more source

Sixty Years at the Rega Institute

Viruses
I started my research career (in 1965) on interferon by identifying polyacrylic acid (PAA) as an interferon inducer. Poly(I).poly(C), discovered by Maurice Hilleman’s group, proved to be more potent as an interferon inducer, and through its mRNA, we were
Erik De Clercq
doaj   +1 more source

Polymeric Forms of Plant Flavonoids Obtained by Enzymatic Reactions

Molecules, 2022
Naringenin is one of the flavonoids originating from citrus fruit. This polyphenol is mainly found in grapefruit, orange and lemon. The antioxidant and antimicrobial properties of flavonoids depend on their structure, including the polymeric form.
Malgorzata Latos-Brozio, Anna Masek, Małgorzata Piotrowska   +2 more
doaj   +1 more source

Distinct Poly(I-C) and Virus-activated Signaling Pathways Leading to Interferon-β Production in Hepatocytes [PDF]

Journal of Biological Chemistry, 2005
Innate cellular antiviral defenses are likely to influence the outcome of infections by many human viruses, including hepatitis B and C viruses, agents that frequently establish persistent infection leading to chronic hepatitis, cirrhosis, and liver cancer.
Kui, Li, Zihong, Chen, Nobuyuki, Kato, Michael, Gale, Stanley M, Lemon   +4 more
openaire   +2 more sources

Detection of Poly(I): Poly(C12U), Mismatched Double-stranded RNA, by Rapid Solution Hybridization: Blood Values after Intravenous Infusion

, 1990
A rapid solution hybridization technique has been developed for estimating blood concentrations of poly(I):poly(C12U), a high molecular weight bioactive double-stranded RNA.
D H Gillespie, D R Strayer, K I Strauss
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Interaction of Antitumor Agent Mitoxantrone with Double Helical Synthetic Polyribonucleotides Poly(G)⋅Poly(C) and Poly(I)⋅Poly(C)

, 2017
The interaction of antitumor drug mitoxantrone (MTX) with double-stranded synthetic RNA homopolymers has been studied by means of spectroscopic (UV-Visible absorption, circular dichroism) techniques.
Rusanna S. Ghazaryan, Yuri S. Babayan, Mariam A. Shahinyan, Sergey N. Hakobyan   +3 more
core   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

TLR3 activation in astrocytes attenuates the nigrostriatal pathway degeneration in rodent models of Parkinson’s disease

Frontiers in Cellular Neuroscience
Toll-like receptor 3 (TLR3) is classically known for mediating inflammatory pathways in Parkinson’s disease (PD). However, the role of TLR3 in nigrostriatal degeneration in PD remains unclear.
Jaeyeong Jeong, So-Yoon Won, Young Cheul Chung, Young Cheul Chung, Won-Ho Shin, Won-Ho Shin, Byung Kwan Jin, Eun S. Park, Eun S. Park   +8 more
doaj   +1 more source