Results 61 to 70 of about 1,496,050 (296)

TLR3 Agonist Amplifies the Anti-Inflammatory Potency of ADSCs via IL-10-Mediated Macrophage Polarization in Acute Pancreatitis

Stem Cells International
The immunoregulatory role of mesenchymal stem cells (MSCs) in inflammation is heterogeneous and can exhibit anti-inflammatory or proinflammatory properties depending on the microenvironment. We herein observed that the activation of Toll-like receptor 3 (
Jianxing Liu, Wenjing Yan, Shanshan Chen, Yingjie Sun, Fangfang Zhang, Yue Yang, Liang Jin   +6 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Coronal Temperature Diagnostic Capability of the Hinode/X-Ray Telescope Based on Self-Consistent Calibration [PDF]

, 2010
The X-Ray Telescope (XRT) onboard the Hinode satellite is an X-ray imager that observes the solar corona with unprecedentedly high angular resolution (consistent with its 1" pixel size).
A. Collura, B.L. Henke, D.H. Brooks, D.H. Brooks, E. DeLuca, E. Landi, F. Urayama, F. Urayama, F.R. Powell, G.S. Vaiana, H. Hara, H. Hara, J. Cirtain, J.D. Jackson, J.E. Vernazza, J.F. Osantowski, J.T. Schmelz, J.T. Schmelz, J.T. Schmelz, K.P. Dere, K.P. Dere, K.P. Dere, K.P. Dere, L. Golub, L. Golub, L. Spitzer Jr., L.W. Acton, M. Shimojo, M. Weber, M.W. Charles, N. Narukage, P. Grigis, P.C.H. Martens, R. Kano, R. Kano, R. Kano, R. Mewe, R. Mewe, S. Tsuneta, S. Tsuneta, S.L. Freeland, T. Bando, T. Kosugi, T. Sakao, T. Shimizu, U. Feldman, Y. Ogawara   +46 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Influence of the bulk and surface morphology on adhesion of polystyrene-inter-poly-cross-2-ethylhexyl-methacrylate films and particles [PDF]

, 1995
The adhesion behavior of semi-interpenetrating polymer networks (semi-IPNs) of linear polystyrene (PS) in crosslinked poly-2-ethylhexylmethacrylate (EHMA) was studied by variation of the bulk and surface morphology, i.e., domain size, continuity, and ...
Albers, Pieter-Jan W., Graaf, Leontine A. de, Möller, Martin   +2 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Effect of Poly I:C on Experimental Respiratory Infection in Hamsters [PDF]

Applied Microbiology, 1970
The interferon inducer double-stranded polyinosinic acid and polycytidylic acid (poly I:C) was studied in hamsters experimentally infected with parainfluenza 3 virus. Upper intranasal, deep intranasal, or intraperitoneal treatment of hamsters with poly I:C (100 μg/100- to 120-g animal) 24 hr before an upper respiratory infection significantly reduced ...
openaire   +2 more sources

PROTECTIVE EFFECT OF POLY I:C AGAINST SISOMICIN NEPHBOTOXICITY IN RABBITS [PDF]

Pediatric Research, 1980
The protective effect of Poly I:C during sisomicin nephrotoxicity in rabbits was determined by measurement of the urinary enzymes alkaline phosphatase (AF),lactic dehydrogenase (LDH) and N-a-cetyl-β-glycosaminidase(NAG). 18 rabbits were divided in 3 Groups.
ZEIS, PM, NACOPOULOU, L, GOURIOTIS, D, PIERROUTSAKOS, I, KOUKOUTSAKIS, P, POGAS, N, VLACHOS, P   +6 more
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Poly-MTO, {(CH_3)_{0.92} Re O_3}_\infty, a Conducting Two-Dimensional Organometallic Oxide [PDF]

, 2005
Polymeric methyltrioxorhenium, {(CH_{3})_{0.92}ReO_{3}}_{\infty} (poly-MTO), is the first member of a new class of organometallic hybrids which adopts the structural pattern and physical properties of classical perovskites in two dimensions (2D).
B. L. Altshuler, C. C. Tsuei, C. Helbig, C. Helbig, E.-W. Scheidt, F. Mayr, G. Eickerling, H.-A. Krug von Nidda, J. F. Gibson, J. Mink, J. T. Szymanski, P. Kiprof, P. Schwab, R. Herrmann, R. Miller, R. Miller, V. Eyert, W. A. Herrmann, W. Scherer   +18 more
core   +4 more sources