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Hemostatic toxicity of poly I-C

Toxicology and Applied Pharmacology, 1972
Abstract Intravenous therapy in beagles with Poly I-C resulted in a dose-related toxicity. In animals receiving 3.0 mg/kg, the clinical and pathological evidence indicated that disseminated intravascular coagulation (DIC) led directly to their death. In animals receiving 0.3 mg/kg evidence for DIC was present both by clinical and pathological studies;
H R, Gralnick   +3 more
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Physical and Enzymatic Studies on Poly d(I–C).Poly d(I–C), an Unusual Double-helical DNA

Nature, 1970
X-ray diffraction and circular dichroism studies indicate that poly d(I–C).poly d(I–C) exists in a new polynucleotide configuration—an eight-fold helix, possibly left-handed.
Y, Mitsui   +6 more
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Poly I : C in herpetic keratitis in rabbits

Experimental Eye Research, 1974
Abstract Herpetic keratoconjunctivitis, induced in rabbit eyes, was experimentally treated with poly-inosinic and poly-cytidilic acid (poly I : C), idoxuridine (IDU) and a combination thereof. It appeared that IDU 0·1% four times daily and poly I:C 1 mg/ml twice daily combined are more effective than either IDU four times daily or poly I:C twice or ...
J A, Oosterhuis   +3 more
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Interaction of metal ions with polynucleotides and related compounds. IX. Unwinding and rewinding of poly(A + U) and poly(I + C) by copper(II) ions

Biopolymers, 1967
AbstractIt is demonstrated that, poly(A + U) and poly(I + C) are both formed under low ionic strength conditions. Continuous variation studies indicate the formation of copper(II) complexes of poly A, poly C, and poly I, but not of poly U. Copper(II) in a 1:1 ratio to polynucleotide prevents the formation of poly(A + U) and brings about the ...
G L, Eichhorn, E, Tarien
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Spectrophotometric and fluorescence polarization studies of the binding of ethidium, daunomycin and mepacrine to DNA and to poly(I · C)

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1977
The changes in the visible absorption spectrum and the degree of fluorescence polarization of daunomycin and mepacrine on binding to DNA have been compared with those shown by the archetypical intercalating agent ethidium. The changes are qualitatively similar for the three drugs, namely a bathochromic shift and hypochromicity (giving an isosbestic ...
T W, Plumbridge, J R, Brown
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