Results 251 to 260 of about 1,496,050 (296)

A Comprehensive Review of poly(I: C) as a Tool for Investigating Astrocytic TLR3 Signaling

Neurochemical Research
Astrocytes play a crucial role in regulating the structure, function, and interactions between the synaptic and vascular compartments in the brain. Toll-like receptor 3 (TLR3) is expressed in astrocytes and recognizes double-stranded RNA (dsRNA), a pathogen-associated molecular pattern (PAMP).
Leonardo, Viana-de-Lima, Nicolle, Platt, Isabele Haruna Ono, Zamaro, Gabriela Duarte, Karasiak, Manuella Pinto, Kaster   +4 more
openaire   +2 more sources

Occurrence of Radical Cation Localization in Chemically Modified Poly(methylphenylsilane):  Poly(methylphenyl-co-4-dimethylaminophenylmethylsilane)s and Poly(methylphenyl-co-4-bromophenylmethylsilane)s

Chemistry of Materials, 1999
Chemical modification of poly(methylphenylsilane) 1 using triflate chemistry gave two series of random copolymers with different composition ratios, viz., poly(methylphenyl-co-4-dimethylaminophenylmethylsilane)s 3−7 and poly(methylphenyl-co-4-bromophenylmethylsilane)s 8−9.
Thomas J. Cleij, Jennifer K. King, Leonardus W. Jenneskens   +2 more
openaire   +1 more source

Optimization of an immunotherapeutic protocol with poly(I,C)-LC.

Journal of biological response modifiers, 1986
The development of successful immunotherapeutic protocols requires new therapeutic strategies as well as the development of clinically predictive tumor models and protocols. A bell-shaped response curve is observed with many biological response modifiers (BRMs), not only for immunomodulation, but also for therapeutic activity.
J E, Talmadge, D, Hartmann
openaire   +1 more source

Critical Strains in Poly(ε-caprolactone) and Blends with Poly(vinyl methyl ether) and Poly(styrene-co-acrylonitrile)

Macromolecules, 2003
The deformation properties under a tensile load of poly(e-caprolactone) (PCL) were compared to those of PCL/PVME and PCL/SAN mixtures. The critical strains at the end of the Hooke range (point A) and at the yield point (point B) remain unchanged. The critical strain marking the beginning of a disintegration of the blocklike crystallites and a fibril ...
Y. Men, G. Strobl
openaire   +1 more source

A preliminary trial of poly(I,C)-LC in multiple sclerosis.

Journal of biological response modifiers, 1986
An open Phase I trial of poly(I,C)-LC in multiple sclerosis was conducted. Serious temperature elevations were typical and associated with transient accentuation of neurological dysfunction which required intensive nursing care, but no permanent complications to the treatment were observed. A regimen was developed for management of the side effects and
D E, McFarlin, C T, Bever, A M, Salazar, H B, Levy   +3 more
openaire   +1 more source

Immunomodulatory effects of poly(I,C)-LC in cancer patients.

Journal of biological response modifiers, 1986
Poly(I,C)-LC was administered in low (1 mg/m2) and intermediate (4 mg/m2) doses to cancer patients by intramuscular injection or intravenous infusion to evaluate the immunomodulatory effects. Natural killer cell (NK) activity was elevated slightly at the low dose and remained unchanged overall, but some depression was observed at the 4 mg/m2 ...
A E, Maluish, J W, Reid, E A, Crisp, W R, Overton, H, Levy, K A, Foon, R B, Herberman   +6 more
openaire   +1 more source

Role of nitric oxide in poly(I-C)-induced endothelial cell expression of leukocyte adhesion molecules

American Journal of Physiology-Heart and Circulatory Physiology, 1997
Polyinosinic-polycytidylic acid [poly(I-C)] is a synthetic double-stranded RNA (dsRNA) that simulates a viral-infected state in cells. It has been shown that viral infection, as well as poly(I-C), stimulates leukocyte adhesion to endothelial cell (EC) monolayers and that this is mediated through the surface expression of the adhesion molecules E ...
T R, Faruqi, S C, Erzurum, F T, Kaneko, P E, DiCorleto   +3 more
openaire   +2 more sources

Heterogeneity of rabbit serum interferon induced by poly I?C

Archiv f�r die gesamte Virusforschung, 1974
Two interferon components having different molecular weights were determined by gel filtration studies in non-purified rabbit serum interferon obtained 4 hours after intravenous administration of 200 μg poly I∶C. The high molecular component (M.W. ≧100,000) corresponded to a minor part (16.85 per cent) of the total interferon activity.
openaire   +2 more sources

Poly I‐C Induces Early Embryo Loss in F344 Rats: a Potential Role for NK Cells

American Journal of Reproductive Immunology, 2005
Problem:  Natural killer (NK) cells were associated with first trimester embryo loss. The current study in the inbred F344 rat assessed the role of NK cells in mediating resorptions caused by poly I‐C, a non‐specific immunostimulator.Method of study:  On fifth day of gestation, rats were injected intraperitoneally with anti‐NKR‐P1 (1.5 mg/kg, i.p.) to ...
Michal, Arad, Shir, Atzil, Keren, Shakhar, Anat, Adoni, Shamgar, Ben-Eliyahu   +4 more
openaire   +2 more sources

Particulate formulations for the delivery of poly(I:C) as vaccine adjuvant

Advanced Drug Delivery Reviews, 2013
Current research and development of antigens for vaccination often center on purified recombinant proteins, viral subunits, synthetic oligopeptides or oligosaccharides, most of them suffering from being poorly immunogenic and subject to degradation.
Hafner Annina M., Corthésy Blaise E., Merkle Hans Peter   +2 more
openaire   +2 more sources