Results 261 to 270 of about 1,496,050 (296)

Poly(I,C)-LC as an interferon inducer in refractory multiple myeloma.

Journal of biological response modifiers, 1986
Seven patients with refractory multiple myeloma (readily evaluable for response) were treated in a Phase II trial with poly(I,C)-LC using a 3 times per week intravenous schedule. Serial immunologic testing included assessment of natural killer (NK) cell activity, antibody-dependent cytotoxicity, delayed hypersensitivity, and in vitro mitogen responses.
B G, Durie, H B, Levy, J, Voakes, J R, Jett, A S, Levine   +4 more
openaire   +1 more source

Phase I trials of poly(I,C) complexes in advanced cancer.

Journal of biological response modifiers, 1986
We have performed Phase I trials of two synthetic double-stranded polyribonucleotide complexes--poly(I,C)-LC, a complex of polyinosinic-polycytidylic acid with poly-L-lysine and carboxymethylcellulose, and poly(I,C)-L, which lacks carboxymethylcellulose--in patients with advanced cancer.
S E, Krown, D, Kerr, W E, Stewart, A K, Field, H F, Oettgen   +4 more
openaire   +1 more source

A phase I evaluation of poly(I,C)-LC in cancer patients.

Journal of biological response modifiers, 1986
Twenty-five patients with metastatic carcinoma were entered into a Phase I clinical trial using poly(I,C)-LC at either 1 mg/m2 or 4 mg/m2 intravenous, twice weekly, for 4 weeks. None of the 15 patients entered at the 1 mg/m2 dose had an objective response; three had progressive disease.
H C, Stevenson, P G, Abrams, C S, Schoenberger, R B, Smalley, R B, Herberman, K A, Foon   +5 more
openaire   +1 more source

Pharmacokinetic and therapeutic activity of polyinosinic-polycytidylic acid stabilized with poly-L-lysine in carboxymethylcellulose [poly(I,C)-LC].

Journal of biological response modifiers, 1986
Polyinosinic-polycytidylic acid stabilized with poly-L-lysine in carboxymethylcellulose [poly(I,C)-LC] significantly augmented natural killer (NK) cell activity in several tissues. Macrophage (M phi) tumoricidal activity was also markedly increased. Both effector cells were active for 9 days. Poly(I,C)-LC also increased effector cell response in vitro.
M A, Chirigos, E, Schlick, R, Ruffmann, W, Budzynski, P, Sinibaldi, E, Gruys   +5 more
openaire   +1 more source

Poly I: C Alleviated Duck Intestinal Injury Infected with Duck Viral Enteritis by Inhibiting Apoptosis

Current Microbiology
Duck enteritis virus (DEV) may lead to vascular injury, gastrointestinal mucosal erosion, lymphoid organ injury, and Polyinosinic-polycytidylic acid (Poly I:C) has an antiviral effect by inducing low levels of interferon. The purpose of this study was to explore the pathogenesis of DEV-induced intestinal injury in ducks and to verify the therapeutic ...
Yangzi, Zhang, Yutong, Wu, Xiaoke, Zhang, Xuan, Wang, Ling, Pu, Jinge, Xu, Zhengchang, Wen, Ming, Wen   +7 more
openaire   +2 more sources

The synthesis and characterization of poly d(I-C) poly d(I-C)

Journal of the American Chemical Society, 1968
R C, Grant, S J, Harwood, R D, Wells
openaire   +2 more sources

Effect of interferon and poly I: C on DNA fiber propagation in L 929 cells.

Archivum immunologiae et therapiae experimentalis, 1979
Autoradiographic analysis of DNA fiber replication was used to measure the rate of DNA propagation, the distances between initiation points of adjacent replicons and the direction of DNA propagation in L929 cells treated with either interferon or poly I: C, or untreated.
M, Korbecki, W, Sawicki, M, Kobus
openaire   +1 more source

Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression

Nature Reviews Molecular Cell Biology, 2021
Lori A Passmore, Jeff Coller
exaly  

Poly(dimethylsilylenemethylene-co- dimethylsiloxane):  A Regularly Alternating Copolymer of Poly(dimethylsiloxane) and Poly(dimethylsilylenemethylene)

Macromolecules, 2001
Leonard V. Interrante, Qionghua Shen, Jun Li   +2 more
openaire   +1 more source

Effects of poly(I,C)-LC on growth and differentiation of normal and malignant myelopoietic progenitor cells.

Journal of biological response modifiers, 1986
Polyriboinosinic-polycytidylic acid with poly-L-lysine stabilized with carboxymethylcellulose [poly(I,C)-LC] augmented, in a dose- and time-dependent manner, secretion of colony-stimulating factor (CSF) by peritoneal macrophages (M phi) and bone marrow cells (BMC).
E, Schlick, F, Bettens, R, Ruffmann, M A, Chirigos, P, Hewetson   +4 more
openaire   +1 more source