Results 261 to 270 of about 39,772,641 (314)

Hemostatic toxicity of poly I-C

Toxicology and Applied Pharmacology, 1972
Abstract Intravenous therapy in beagles with Poly I-C resulted in a dose-related toxicity. In animals receiving 3.0 mg/kg, the clinical and pathological evidence indicated that disseminated intravascular coagulation (DIC) led directly to their death. In animals receiving 0.3 mg/kg evidence for DIC was present both by clinical and pathological studies;
H R, Gralnick, L L, Shott, R P, Zendzian, E, Homan   +3 more
openaire   +2 more sources

Physical and Enzymatic Studies on Poly d(I–C).Poly d(I–C), an Unusual Double-helical DNA

Nature, 1970
X-ray diffraction and circular dichroism studies indicate that poly d(I–C).poly d(I–C) exists in a new polynucleotide configuration—an eight-fold helix, possibly left-handed.
Y, Mitsui, R, Langridge, B E, Shortle, C R, Cantor, R C, Grant, M, Kodama, R D, Wells   +6 more
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Poly I : C in herpetic keratitis in rabbits

Experimental Eye Research, 1974
Abstract Herpetic keratoconjunctivitis, induced in rabbit eyes, was experimentally treated with poly-inosinic and poly-cytidilic acid (poly I : C), idoxuridine (IDU) and a combination thereof. It appeared that IDU 0·1% four times daily and poly I:C 1 mg/ml twice daily combined are more effective than either IDU four times daily or poly I:C twice or ...
J A, Oosterhuis, W A, Nolen, S H, Sie, J, Versteeg   +3 more
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Interaction of metal ions with polynucleotides and related compounds. IX. Unwinding and rewinding of poly(A + U) and poly(I + C) by copper(II) ions

Biopolymers, 1967
AbstractIt is demonstrated that, poly(A + U) and poly(I + C) are both formed under low ionic strength conditions. Continuous variation studies indicate the formation of copper(II) complexes of poly A, poly C, and poly I, but not of poly U. Copper(II) in a 1:1 ratio to polynucleotide prevents the formation of poly(A + U) and brings about the ...
G L, Eichhorn, E, Tarien
openaire   +2 more sources

Spectrophotometric and fluorescence polarization studies of the binding of ethidium, daunomycin and mepacrine to DNA and to poly(I · C)

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1977
The changes in the visible absorption spectrum and the degree of fluorescence polarization of daunomycin and mepacrine on binding to DNA have been compared with those shown by the archetypical intercalating agent ethidium. The changes are qualitatively similar for the three drugs, namely a bathochromic shift and hypochromicity (giving an isosbestic ...
T W, Plumbridge, J R, Brown
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Occurrence of Radical Cation Localization in Chemically Modified Poly(methylphenylsilane):  Poly(methylphenyl-co-4-dimethylaminophenylmethylsilane)s and Poly(methylphenyl-co-4-bromophenylmethylsilane)s

Chemistry of Materials, 1999
Chemical modification of poly(methylphenylsilane) 1 using triflate chemistry gave two series of random copolymers with different composition ratios, viz., poly(methylphenyl-co-4-dimethylaminophenylmethylsilane)s 3−7 and poly(methylphenyl-co-4-bromophenylmethylsilane)s 8−9.
Thomas J. Cleij, Jennifer K. King, Leonardus W. Jenneskens   +2 more
openaire   +1 more source

A Comprehensive Review of poly(I: C) as a Tool for Investigating Astrocytic TLR3 Signaling

Neurochemical Research
Astrocytes play a crucial role in regulating the structure, function, and interactions between the synaptic and vascular compartments in the brain. Toll-like receptor 3 (TLR3) is expressed in astrocytes and recognizes double-stranded RNA (dsRNA), a pathogen-associated molecular pattern (PAMP).
Leonardo, Viana-de-Lima, Nicolle, Platt, Isabele Haruna Ono, Zamaro, Gabriela Duarte, Karasiak, Manuella Pinto, Kaster   +4 more
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Optimization of an immunotherapeutic protocol with poly(I,C)-LC.

Journal of biological response modifiers, 1986
The development of successful immunotherapeutic protocols requires new therapeutic strategies as well as the development of clinically predictive tumor models and protocols. A bell-shaped response curve is observed with many biological response modifiers (BRMs), not only for immunomodulation, but also for therapeutic activity.
J E, Talmadge, D, Hartmann
openaire   +1 more source