Results 271 to 280 of about 39,772,641 (314)

Critical Strains in Poly( ε -caprolactone) and Blends with Poly(vinyl methyl ether) and Poly(styrene- c o -acrylonitrile)

Macromolecules, 2003
The deformation properties under a tensile load of poly(e-caprolactone) (PCL) were compared to those of PCL/PVME and PCL/SAN mixtures. The critical strains at the end of the Hooke range (point A) and at the yield point (point B) remain unchanged. The critical strain marking the beginning of a disintegration of the blocklike crystallites and a fibril ...
Y. Men, G. Strobl
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A preliminary trial of poly(I,C)-LC in multiple sclerosis.

Journal of biological response modifiers, 1986
An open Phase I trial of poly(I,C)-LC in multiple sclerosis was conducted. Serious temperature elevations were typical and associated with transient accentuation of neurological dysfunction which required intensive nursing care, but no permanent complications to the treatment were observed. A regimen was developed for management of the side effects and
D E, McFarlin, C T, Bever, A M, Salazar, H B, Levy   +3 more
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Immunomodulatory effects of poly(I,C)-LC in cancer patients.

Journal of biological response modifiers, 1986
Poly(I,C)-LC was administered in low (1 mg/m2) and intermediate (4 mg/m2) doses to cancer patients by intramuscular injection or intravenous infusion to evaluate the immunomodulatory effects. Natural killer cell (NK) activity was elevated slightly at the low dose and remained unchanged overall, but some depression was observed at the 4 mg/m2 ...
A E, Maluish, J W, Reid, E A, Crisp, W R, Overton, H, Levy, K A, Foon, R B, Herberman   +6 more
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Heterogeneity of rabbit serum interferon induced by poly I?C

Archiv f�r die gesamte Virusforschung, 1974
Two interferon components having different molecular weights were determined by gel filtration studies in non-purified rabbit serum interferon obtained 4 hours after intravenous administration of 200 μg poly I∶C. The high molecular component (M.W. ≧100,000) corresponded to a minor part (16.85 per cent) of the total interferon activity.
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Poly I‐C Induces Early Embryo Loss in F344 Rats: a Potential Role for NK Cells

American Journal of Reproductive Immunology, 2005
Problem:  Natural killer (NK) cells were associated with first trimester embryo loss. The current study in the inbred F344 rat assessed the role of NK cells in mediating resorptions caused by poly I‐C, a non‐specific immunostimulator.Method of study:  On fifth day of gestation, rats were injected intraperitoneally with anti‐NKR‐P1 (1.5 mg/kg, i.p.) to ...
Michal, Arad, Shir, Atzil, Keren, Shakhar, Anat, Adoni, Shamgar, Ben-Eliyahu   +4 more
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Particulate formulations for the delivery of poly(I:C) as vaccine adjuvant

Advanced Drug Delivery Reviews, 2013
Current research and development of antigens for vaccination often center on purified recombinant proteins, viral subunits, synthetic oligopeptides or oligosaccharides, most of them suffering from being poorly immunogenic and subject to degradation.
Hafner Annina M., Corthésy Blaise E., Merkle Hans Peter   +2 more
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Poly(I,C)-LC as an interferon inducer in refractory multiple myeloma.

Journal of biological response modifiers, 1986
Seven patients with refractory multiple myeloma (readily evaluable for response) were treated in a Phase II trial with poly(I,C)-LC using a 3 times per week intravenous schedule. Serial immunologic testing included assessment of natural killer (NK) cell activity, antibody-dependent cytotoxicity, delayed hypersensitivity, and in vitro mitogen responses.
B G, Durie, H B, Levy, J, Voakes, J R, Jett, A S, Levine   +4 more
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Phase I trials of poly(I,C) complexes in advanced cancer.

Journal of biological response modifiers, 1986
We have performed Phase I trials of two synthetic double-stranded polyribonucleotide complexes--poly(I,C)-LC, a complex of polyinosinic-polycytidylic acid with poly-L-lysine and carboxymethylcellulose, and poly(I,C)-L, which lacks carboxymethylcellulose--in patients with advanced cancer.
S E, Krown, D, Kerr, W E, Stewart, A K, Field, H F, Oettgen   +4 more
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A phase I evaluation of poly(I,C)-LC in cancer patients.

Journal of biological response modifiers, 1986
Twenty-five patients with metastatic carcinoma were entered into a Phase I clinical trial using poly(I,C)-LC at either 1 mg/m2 or 4 mg/m2 intravenous, twice weekly, for 4 weeks. None of the 15 patients entered at the 1 mg/m2 dose had an objective response; three had progressive disease.
H C, Stevenson, P G, Abrams, C S, Schoenberger, R B, Smalley, R B, Herberman, K A, Foon   +5 more
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Pharmacokinetic and therapeutic activity of polyinosinic-polycytidylic acid stabilized with poly-L-lysine in carboxymethylcellulose [poly(I,C)-LC].

Journal of biological response modifiers, 1986
Polyinosinic-polycytidylic acid stabilized with poly-L-lysine in carboxymethylcellulose [poly(I,C)-LC] significantly augmented natural killer (NK) cell activity in several tissues. Macrophage (M phi) tumoricidal activity was also markedly increased. Both effector cells were active for 9 days. Poly(I,C)-LC also increased effector cell response in vitro.
M A, Chirigos, E, Schlick, R, Ruffmann, W, Budzynski, P, Sinibaldi, E, Gruys   +5 more
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