Results 111 to 120 of about 65,820 (278)

Sequence determinants in human polyadenylation site selection

BMC Genomics, 2003
Background Differential polyadenylation is a widespread mechanism in higher eukaryotes producing mRNAs with different 3' ends in different contexts. This involves several alternative polyadenylation sites in the 3' UTR, each with its specific strength ...
Gautheret Daniel, Legendre Matthieu
doaj   +1 more source

Transcriptome 3′end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma

Nature Communications, 2018
Diversification at the transcriptome 3′end is an important and evolutionarily conserved layer of gene regulation associated with differentiation and dedifferentiation processes. Here, we identify extensive transcriptome 3′end-alterations in neuroblastoma,
A. Ogorodnikov, Michal Levin, Surendra Tattikota, S. Tokalov, M. Hoque, Denise Scherzinger, F. Marini, A. Poetsch, H. Binder, S. Macher-Göppinger, H. Probst, B. Tian, Michael Schaefer, K. Lackner, F. Westermann, S. Danckwardt   +15 more
semanticscholar   +1 more source

Salt Stress Adaptations in Soybean Involve Alterations in Pre‐mRNA Processing

Plant, Cell &Environment, EarlyView.
ABSTRACT Salt stress can seriously affect plant survival. To adapt to salt stress, plants can alter gene expressions and/or pre‐mRNA processing patterns, or both. Previous studies could not comprehensively profile stress‐responsive pre‐mRNA processing patterns due to limitations in traditional sequencing technologies.
Shoudong Zhang, Zhixia Xiao, Ailin Liu, Dongpeng Ren, Shengjie Chen, Hanxue Zhang, Li Zhang, Zhili Wang, Jun Yang, Hon‐Ming Lam   +9 more
wiley   +1 more source

mRNA alternative polyadenylation (APA) in regulation of gene expression and diseases

Genes and Diseases, 2023
The mRNA polyadenylation plays essential function in regulation of mRNA metabolism. Mis-regulations of mRNA polyadenylation are frequently linked with aberrant gene expression and disease progression. Under the action of polyadenylate polymerase, poly(A)
Siyao Guo, Shuibin Lin
doaj  

The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis

Scientific Reports, 2019
Clinically, osteoarthritis (OA) pain is significantly associated with synovial inflammation. Identification of the mechanisms driving inflammation could reveal new targets to relieve this prevalent pain state.
S. Ashraf, M. Radhi, Peter R W Gowler, J. Burston, Raj Gandhi, G. J. Thorn, A. Piccinini, D. Walsh, V. Chapman, C. D. de Moor   +9 more
semanticscholar   +1 more source

Optimised Ribosome Profiling Reveals New Insights Into Translational Regulation in Synchronised Chlamydomonas reinhardtii Cultures

Plant, Cell &Environment, EarlyView.
ABSTRACT Deep sequencing of ribosome footprints, also known as ribosome profiling (Ribo‐seq), enables the quantification of mRNA translation and a comprehensive view of the translatome landscape. Here, we report an optimised Ribo‐seq protocol and analysis pipeline for the model green alga, Chlamydomonas reinhardtiii (Chlamydomonas).
Yen‐Ling Lin, Eva Yuhua Kuo, Shih‐Yi Wang, Chih‐Chi Lee, Su‐Chiung Fang   +4 more
wiley   +1 more source

Unveiling roles of non‐coding RNAs in cancer through advanced technologies

Quantitative Biology, Volume 13, Issue 4, December 2025.
Abstract Non‐coding RNAs (ncRNAs) have emerged as key regulators in tumorigenesis. In this perspective, we briefly review the significance of ncRNA in cancer biology and highlight recent technological advancements in characterization of ncRNA in cancer research. Specifically, we discuss how these advanced approaches, such as Patho‐DBiT, CRISPR screens,
Runhao Wang, Leng Han
wiley   +1 more source

Arabidopsis mRNA polyadenylation machinery: comprehensive analysis of protein-protein interactions and gene expression profiling

BMC Genomics, 2008
Background The polyadenylation of mRNA is one of the critical processing steps during expression of almost all eukaryotic genes. It is tightly integrated with transcription, particularly its termination, as well as other RNA processing events, i.e ...
Mo Min, Xing Denghui, Meeks Lisa R, Forbes Kevin P, Rao Suryadevara, Addepalli Balasubrahmanyam, Xu Ruqiang, Hunt Arthur G, Zhao Hongwei, Bandyopadhyay Amrita, Dampanaboina Lavanya, Marion Amanda, Von Lanken Carol, Li Qingshun   +13 more
doaj   +1 more source

Polyadenylation and reverse transcription of influenza viral RNA [PDF]

, 1979
J.S. Emtage, Graham Catlin, N. H. Carey
openalex   +1 more source

Molecular basis for the recognition of the human AAUAAA polyadenylation signal

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance The AAUAAA polyadenylation signal (PAS) was identified more than 40 years ago, but it has remained a mystery how this signal is recognized at the molecular level, which is required for the 3′-end processing of nearly all eukaryotic messenger
Yadong Sun, Yixiao Zhang, K. Hamilton, J. Manley, Yongsheng Shi, T. Walz, L. Tong   +6 more
semanticscholar   +1 more source