Results 111 to 120 of about 57,483 (236)
International Journal of Cancer, Volume 158, Issue 3, Page 475-487, 1 February 2026.Abstract Hepatocellular carcinoma (HCC) represents the predominant form of primary liver cancer and is frequently identified at a late stage, necessitating systemic therapy. However, resistance to first‐line tyrosine kinase inhibitor therapies, such as sorafenib and lenvatinib, remains a significant clinical challenge.
Longtao Zhao +6 more
wiley +1 more source
Cleavage and Polyadenylation Specificity Factor Subunit 5 Regulates Pulmonary Artery Smooth Muscle Expansion and Hypoxic Response [PDF]
MedComm (2020)Increased miR‐3163 targets NUDT21, reducing CPSF5 levels and driving APA dysregulation. This results in 3′UTR shortening of CBFB, which stabilizes RUNX1 and promotes smooth muscle proliferation. PTGER3, is also shortened amplifying hypoxia‐induced RVSP. Together, these pathways contribute to vascular remodeling in PH. Image Created in https://BioRender.
Collum S +17 more
europepmc +2 more sources
Decision letter: Alternative polyadenylation mediates genetic regulation of gene expression
, 2020 openalex +1 more source
Antisense transcription regulates the expression of sense gene via alternative polyadenylation [PDF]
, 2017 Ting Shen +7 more
openalex +1 more source
Current Trends in Duchenne Muscular Dystrophy Research and Therapy: 3D Cardiac Modelling
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.ABSTRACT Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, presents a multifaceted challenge that affects both skeletal muscle function and cardiomyocyte homeostasis, causing progressive degeneration and life‐threatening cardiac complications by adolescence.
Marta Przymuszała +3 more
wiley +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.ABSTRACT Background Skeletal muscle wasting and weakness are prominent disease features. Originally considered to arise from common transcriptional changes, recent analyses demonstrated that different stimuli induce muscle wasting via largely distinct mRNA and protein changes.
Anna Stephan +6 more
wiley +1 more source
Supplementary Data from Characterization of Immune-Related Alternative Polyadenylation Events in Cancer Immunotherapy [PDF]
, 2023 Gaoyang Wang +11 more
openalex +1 more source
The nuclear poly(A) binding protein of mammals, but not of fission yeast, participates in mRNA polyadenylation [PDF]
, 2017 Uwe Kühn +2 more
openalex +1 more source
Deciphering the Transcriptomic Signatures of Aging Across Organs in Mice
Aging Cell, Volume 25, Issue 2, February 2026.Comprehensive transcriptomic profiling of eight mouse organs across six ages reveals how aging reshapes biological processes. Trajectory and network analyses distinguish shared and organ‐specific signatures, charting the molecular landscape of systemic aging.
Sarah Morsy +9 more
wiley +1 more source