Results 121 to 130 of about 65,820 (278)
Biotechnology and Bioengineering, Volume 122, Issue 7, Page 1640-1655, July 2025.ABSTRACT Recombinant adeno associated virus (rAAV) vectors have become popular delivery vehicles for in vivo gene therapies, but demand for rAAVs continues to outpace supply. Platform processes for rAAV production are being developed by many manufacturers, and transient chemical transfection of human embryonic kidney 293 (HEK293) cells is currently the
Erica A. Green +9 more
wiley +1 more source
Widespread intronic polyadenylation diversifies immune cell transcriptomes
bioRxiv, 2017 Alternative cleavage and polyadenylation (ApA) is known to alter untranslated region (3ʹUTR) length but can also recognize intronic polyadenylation (IpA) signals to generate transcripts that lose part or all of the coding region.
I. Singh +8 more
semanticscholar +1 more source
Evaluation of a novel, short polyA signal from the Bombyx mori bidensovirus
Invertebrate Survival Journal, 2017 Bombyx mori bidensovirus (BmBDV) is the only virus which belongs to the new Bidnaviridae family established by the International Committee on Taxonomy of Viruses in 2012.
M Wang +7 more
doaj
The C proteins of heterogeneous nuclear ribonucleoprotein complexes interact with RNA sequences downstream of polyadenylation cleavage sites. [PDF]
, 1988 Jeffrey Wilusz +2 more
openalex +1 more source
Cell Cycle Regulation by Alternative Polyadenylation of CCND1
Scientific Reports, 2018 Global shortening of 3′UTRs by alternative polyadenylation (APA) has been observed in cancer cells. However, the role of APA in cancer remains unknown.
Qiongman Wang +6 more
semanticscholar +1 more source
Journal of Cell Communication and Signaling, Volume 19, Issue 2, June 2025.Abstract CEP162, a 162‐kDa centrosome protein, is a crucial centrosomal adapter, mediating cell differentiation and polarization. CEP162 maintains mitosis by dynamically stabilizing microtubules. CEP162 promotes the transition zone (TZ) assembly in the basal body through interaction with CEP131, CEP290, and axoneme microtubules as well as the distal ...
Jun Yin +7 more
wiley +1 more source
Aberrant polyadenylation by a vesicular stomatitis virus mutant is due to an altered L protein [PDF]
, 1984 David M. Hunt +2 more
openalex +1 more source
Orthomyxovirus Replication, Transcription, and Polyadenylation
, 2004 Efficient in vitro and in vivo systems are now in place to study the role of viral proteins in replication and/or transcription, the regulation of these processes, polyadenylation of viral mRNAs, the viral promoter structures, or the significance of noncoding regions for virus replication.
Neumann, G +3 more
openaire +3 more sources
Cleavage and polyadenylation: Ending the message expands gene regulation
RNA Biology, 2017 Cleavage and polyadenylation (pA) is a fundamental step that is required for the maturation of primary protein encoding transcripts into functional mRNAs that can be exported from the nucleus and translated in the cytoplasm. 3′end processing is dependent
Jonathan Neve +4 more
semanticscholar +1 more source
Journal of Cell Communication and Signaling, Volume 19, Issue 2, June 2025.Abstract Chemoresistance and immune evasion remain significant barriers to effective esophageal cancer (EC) treatment. This study explores the mechanistic role of extracellular vesicles (EVs) delivering LncRNA HOTAIR in modulating these processes. Using transcriptomic profiling, LncRNA HOTAIR was identified as a critical factor in EC progression.
Tayier Tuersong +7 more
wiley +1 more source