Results 111 to 120 of about 62,357 (236)
Scientific Reports, 2017 Pre-mRNA alternative splicing and alternative polyadenylation have been implicated to play important roles during eukaryotic gene expression. However, much remains unknown regarding the regulatory mechanisms and the interactions of these two processes in
Qingshun Q. Li +3 more
doaj +1 more source
Viruses, 2019 Human bocavirus 1 (HBoV1) infects well-differentiated (polarized) human airway epithelium (HAE) cultured at an air-liquid interface (ALI). In the present study, we applied next-generation RNA sequencing to investigate the genome-wide transcription ...
Wei Zou +5 more
doaj +1 more source
Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice
Brain Pathology, Volume 36, Issue 4, July 2026.We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga +11 more
wiley +1 more source
Sequence determinants in human polyadenylation site selection
, 2003 Background Differential polyadenylation is a widespread mechanism in higher eukaryotes producing mRNAs with different 3' ends in different contexts. This involves several alternative polyadenylation sites in the 3' UTR, each with its specific strength ...
Gautheret, Daniel +5 more
core +1 more source
Journal of Neurochemistry, Volume 170, Issue 7, July 2026.Amyotrophic lateral sclerosis (ALS) involves widespread cortical pathology beyond the motor cortex. Human‐induced pluripotent stem cell‐derived neural organoids model cortical tissue in vitro and provide a physiologically relevant platform to study disease mechanisms in ALS.
Kristel N. Eigenhuis +2 more
wiley +1 more source
Alternative Polyadenylation Dynamics During the Rice Blast Immune Response
Molecular Plant Pathology, Volume 27, Issue 7, July 2026.In rice, infection by the blast fungus Magnaporthe oryzae triggers genome‐wide alternative polyadenylation (APA) dynamics, leading to widespread 3′ UTR shortening in stress‐responsive transcripts. This shortening enables immunity‐related genes to evade miRNA‐mediated suppression.
Dewei Yang +5 more
wiley +1 more source
Beyond Starch: Towards a Scalable Potato Platform for Molecular Farming
Plant Biotechnology Journal, Volume 24, Issue 7, Page 4619-4639, July 2026.Re‐engineering potato as a biosafe and host‐optimised platform for plant molecular farming by integrating intrinsic biological traits with targeted engineering strategies. ABSTRACT Thirty‐five years after the first recombinant protein was produced in potato and 30 years after clinical trials of edible vaccines from its tubers, the crop is being ...
Izabela Anna Chincinska +2 more
wiley +1 more source
, 2013 (A) Histogram of clustered polyadenylation sites (PACs) and their normalized position on ORFs. On the x-axis, 0 and 1 refer to the first and last base of the ORF. Only polyadenylation sites of the sense direction with respect to the ORF are shown.
Oscar Franzén (172092) +6 more
core +1 more source
Editorial: Alternative Polyadenylation in Development and Disease
Frontiers in Genetics, 2022 Athma A. Pai, Yang I. Li, Paolo Provero
doaj +1 more source
Salt Stress Adaptations in Soybean Involve Alterations in Pre‐mRNA Processing
Plant, Cell &Environment, Volume 49, Issue 7, Page 4000-4014, July 2026.ABSTRACT Salt stress can seriously affect plant survival. To adapt to salt stress, plants can alter gene expressions and/or pre‐mRNA processing patterns, or both. Previous studies could not comprehensively profile stress‐responsive pre‐mRNA processing patterns due to limitations in traditional sequencing technologies.
Shoudong Zhang +9 more
wiley +1 more source