Results 41 to 50 of about 104,144 (317)

Specificity factors in cytoplasmic polyadenylation [PDF]

WIREs RNA, 2013
Poly(A) tail elongation after export of an messenger RNA (mRNA) to the cytoplasm is called cytoplasmic polyadenylation. It was first discovered in oocytes and embryos, where it has roles in meiosis and development. In recent years, however, has been implicated in many other processes, including synaptic plasticity and mitosis.
Charlesworth, A., Meijer, Hedda A., de Moor, C. H.   +2 more
openaire   +6 more sources

Natural antisense transcripts with coding capacity in Arabidopsis may have a regulatory role that is not linked to double-stranded RNA degradation [PDF]

, 2005
BACKGROUND: Overlapping transcripts in antisense orientation have the potential to form double-stranded RNA (dsRNA), a substrate for a number of different RNA-modification pathways.
Jen, C.H., Meyer, P., Michalopoulos, I., Westhead, D.R.   +3 more
core   +2 more sources

Choice of Alternative Polyadenylation Sites, Mediated by the RNA-Binding Protein Elavl3, Plays a Role in Differentiation of Inhibitory Neuronal Progenitors

Frontiers in Cellular Neuroscience, 2019
Alternative polyadenylation (APA) is a widespread mechanism involving about half of the expressed genes, resulting in varying lengths of the 3′ untranslated region (3′UTR).
Elena Grassi, Roberto Santoro, Alessandro Umbach, Anna Grosso, Salvatore Oliviero, Salvatore Oliviero, Francesco Neri, Francesco Neri, Luciano Conti, Ugo Ala, Paolo Provero, Ferdinando DiCunto, Ferdinando DiCunto, Giorgio R. Merlo   +13 more
doaj   +1 more source

Virulence- and signaling-associated genes display a preference for long 3′UTRs during rice infection and metabolic stress in the rice blast fungus [PDF]

, 2019
Generation of mRNA isoforms by alternative polyadenylation (APA) and their involvement in regulation of fungal cellular processes, including virulence, remains elusive.
Demuez, Marie, Marconi, Marco, Ortega-Campayo, Víctor, Rodríguez-Romero, Julio, Sesma, Ane, Wilkinson, Mark D.   +5 more
core   +1 more source

A multispecies polyadenylation site model [PDF]

BMC Bioinformatics, 2013
Polyadenylation is present in all three domains of life, making it the most conserved post-transcriptional process compared with splicing and 5'-capping. Even though most mammalian poly(A) sites contain a highly conserved hexanucleotide in the upstream region and a far less conserved U/GU-rich sequence in the downstream region, there are many ...
Samuel I. Gunderson, Eric S. Ho, Siobain Duffy   +2 more
openaire   +3 more sources

Alterations in polyadenylation and its implications for endocrine disease

Frontiers in Endocrinology, 2013
IntroductionPolyadenylation is the process in which the pre-mRNA is cleaved at the poly(A) site and a poly(A) tail is added - a process necessary for normal mRNA formation.
Anders eRehfeld, Mireya ePlass, Anders eKrogh, Lennart eFriis-Hansen   +3 more
doaj   +1 more source

Intragenic CpG Islands and Their Impact on Gene Regulation

Frontiers in Cell and Developmental Biology, 2022
The mammalian genome is depleted in CG dinucleotides, except at protected regions where they cluster as CpG islands (CGIs). CGIs are gene regulatory hubs and serve as transcription initiation sites and are as expected, associated with gene promoters ...
James A. Cain, Bertille Montibus, Rebecca J. Oakey   +2 more
doaj   +1 more source

Writing a wrong: Coupled RNA polymerase II transcription and RNA quality control [PDF]

, 2019
Processing and maturation of precursor RNA species is coupled to RNA polymerase II transcription. Co-transcriptional RNA processing helps to ensure efficient and proper capping, splicing, and 3' end processing of different RNA species to help ensure ...
Hughes, Katlyn D., Mosley, Amber L., Peck, Sarah A., Victorino, Jose F.   +3 more
core   +1 more source

Alternative Polyadenylation: a new frontier in post transcriptional regulation

Biomarker Research, 2020
Polyadenylation of pre-messenger RNA (pre-mRNA) specific sites and termination of their downstream transcriptions are signaled by unique sequence motif structures such as AAUAAA and its auxiliary elements.
F. Ren, N. Zhang, Lan Zhang, E. Miller, J. Pu   +4 more
semanticscholar   +1 more source

Polyadenylation: A tail of two complexes [PDF]

Current Biology, 2002
Recent studies have uncovered new connections between the enzymes of mRNA 3' end processing and RNA polymerase II. These connections improve the efficiency of polyadenylation and signal to the polymerase to terminate transcription; their discovery reveals another level of gene regulation.
Nick J. Proudfoot, Justin M. O'Sullivan
openaire   +3 more sources