Results 41 to 50 of about 65,820 (278)
Polyadenylation: A tail of two complexes [PDF]
Current Biology, 2002 Recent studies have uncovered new connections between the enzymes of mRNA 3' end processing and RNA polymerase II. These connections improve the efficiency of polyadenylation and signal to the polymerase to terminate transcription; their discovery reveals another level of gene regulation.
Nick J. Proudfoot, Justin M. O'Sullivan
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PolyASite 2.0: a consolidated atlas of polyadenylation sites from 3′ end sequencing
Nucleic Acids Res., 2019 Generated by 3′ end cleavage and polyadenylation at alternative polyadenylation (poly(A)) sites, alternative terminal exons account for much of the variation between human transcript isoforms.
Christina J. Herrmann +5 more
semanticscholar +1 more source
Alternative poladenylation of tumor suppressor genes in small intestinal neuroendocrine tumors
Frontiers in Endocrinology, 2014 The tumorigenesis of small intestinal neuroendocrine tumors is poorly understood. Recent studies have associated alternative polyadenylation with proliferation, cell transformation and cancer.
Anders eRehfeld +6 more
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Biomolecules, 2020 A crucial feature of gene expression involves RNA processing to produce 3′ ends through a process termed 3′ end cleavage and polyadenylation (CPA). This ensures the nascent RNA molecule can exit the nucleus and be translated to ultimately give rise to a ...
J. Nourse, S. Spada, S. Danckwardt
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Recognition of polyadenylation sites in yeast pre-mRNAs by cleavage and polyadenylation factor [PDF]
The EMBO Journal, 2001 Recognition of poly(A) sites in yeast pre-mRNAs is poorly understood. Employing an in vitro cleavage system with cleavage and polyadenylation factor (CPF) and cleavage factor IA we show that the efficiency and positioning elements are dispensable for poly(A)-site recognition within a short CYC1 substrate in vitro.
Dichtl, B., Keller, W.
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Nature Communications, 2018 Cyclin-dependent kinase 12 (CDK12) modulates transcription elongation by phosphorylating the carboxy-terminal domain of RNA polymerase II and selectively affects the expression of genes involved in the DNA damage response (DDR) and mRNA processing.
M. Krajewska +19 more
semanticscholar +1 more source
APAlyzer: a bioinformatics package for analysis of alternative polyadenylation isoforms
Bioinform., 2020 SUMMARY Most eukaryotic genes produce alternative polyadenylation (APA) isoforms. APA is dynamically regulated under different growth and differentiation conditions.
Ruijia Wang, B. Tian
semanticscholar +1 more source
Widespread intronic polyadenylation inactivates tumor suppressor genes in leukemia
Nature, 2018 DNA mutations are known cancer drivers. Here we investigated whether mRNA events that are upregulated in cancer can functionally mimic the outcome of genetic alterations. RNA sequencing or 3′-end sequencing techniques were applied to normal and malignant
Shih-Han Lee +5 more
semanticscholar +1 more source
RNA Binding Proteins that Control Human Papillomavirus Gene Expression
Biomolecules, 2015 The human papillomavirus (HPV) life cycle is strictly linked to the differentiation program of the infected mucosal epithelial cell. In the basal and lower levels of the epithelium, early genes coding for pro-mitotic proteins and viral replication ...
Naoko Kajitani, Stefan Schwartz
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Regulation of Germ Cell mRNPs by eIF4E:4EIP Complexes: Multiple Mechanisms, One Goal
Frontiers in Cell and Developmental Biology, 2020 Translational regulation of mRNAs is critically important for proper gene expression in germ cells, gametes, and embryos. The ability of the nucleus to control gene expression in these systems may be limited due to spatial or temporal constraints, as ...
Hayden P. Huggins, Brett D. Keiper
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