Results 81 to 90 of about 57,483 (236)

3′UTR variants of ALS‐linked RNAs modify subcellular and cellular phenotypes

The FEBS Journal, EarlyView.
Our study demonstrates that alternative 3′UTR variants of ALS‐linked transcripts modulate subcellular RNA localization and cytoskeletal architecture. NEFH 3′UTR‐Long promotes nuclear RNA clustering, while SOD1 3′UTR‐Long reduces filopodia formation. These results suggest that 3′UTRs, independent of coding sequences, can influence neuronal phenotypes ...
Melis Savasan‐Sogut, Danae Campos‐Melo, Michael J. Strong   +2 more
wiley   +1 more source

Evaluation of a novel, short polyA signal from the Bombyx mori bidensovirus

Invertebrate Survival Journal, 2017
Bombyx mori bidensovirus (BmBDV) is the only virus which belongs to the new Bidnaviridae family established by the International Committee on Taxonomy of Viruses in 2012.
M Wang, Q Yu, Y Li, Y Zhang, D Miao, Z Hu, Q Yao, K Chen   +7 more
doaj  

Interplay between Alternative Splicing and Alternative Polyadenylation Defines the Expression Outcome of the Plant Unique OXIDATIVE TOLERANT-6 Gene

Scientific Reports, 2017
Pre-mRNA alternative splicing and alternative polyadenylation have been implicated to play important roles during eukaryotic gene expression. However, much remains unknown regarding the regulatory mechanisms and the interactions of these two processes in
Qingshun Q. Li, Zhaoyang Liu, Wenjia Lu, Man Liu   +3 more
doaj   +1 more source

Single cell 3’UTR analysis identifies changes in alternative polyadenylation throughout neuronal differentiation and in autism [PDF]

, 2020
Manuel Göpferich, Nikhil Oommen George, Ana Domingo-Muelas, Alex Bizyn, Rosa Pascual, Daria Fijałkowska, Georgios Kalamakis, Ulrike Müller, Jeroen Krijgsveld, Raúl Méndez, Isabel Fariñas, Wolfgang Huber, Simon Anders, Ana Martín-Villalba   +13 more
openalex   +1 more source

Genome-wide identification of dominant polyadenylation hexamers for use in variant classification [PDF]

, 2023
Henoke Shiferaw, Celine Hong, D.N. Cooper, Jennifer J. Johnston, Nisc, Leslie G. Biesecker   +5 more
openalex   +1 more source

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

The FEBS Journal, EarlyView.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio, Ana Lucia Cuadros Gamboa, Martina Bertocchi, Filippo Chiesa, Francesca Cargnin, Ettore Mosca, Paride Pelucchi, Viviana Tritto, Stefania Corti, Isabella Ceccherini, Paola Riva, Roberta Benfante, Diego Fornasari   +12 more
wiley   +1 more source

Sequence determinants in human polyadenylation site selection

BMC Genomics, 2003
Background Differential polyadenylation is a widespread mechanism in higher eukaryotes producing mRNAs with different 3' ends in different contexts. This involves several alternative polyadenylation sites in the 3' UTR, each with its specific strength ...
Gautheret Daniel, Legendre Matthieu
doaj   +1 more source

3′-End processing of histone pre-mRNAs in Drosophila: U7 snRNP is associated with FLASH and polyadenylation factors [PDF]

, 2013
Ivan Sabath, Aleksandra Skrajna, Cheng Yang, Michał Dadlez, William F. Marzluff, Zbigniew Domiński   +5 more
openalex   +1 more source

Coupling of both a transactivation module and a double‐stranded DNA‐binding domain boosts Cas12i3 variant‐based cytosine and adenine editing in plants

Journal of Integrative Plant Biology, EarlyView.
Fusions of a transactivation module and a double‐stranded DNA‐binding domain produced effective Cas12i3 variant‐based cytosine and adenine base editors, with improved C‐to‐T and A‐to‐G base editing efficiency and expanded editing window. Generated herbicide‐resistant rice germplasm by using these base editors demonstrates their potential for precise ...
Chen Zhang, Jingying Li, Yucai Li, Lei Yan, Christina Seok Yien Yong, Shaoya Li, Yubing He, Lanqin Xia   +7 more
wiley   +1 more source

A Comprehensive RNA-seq Analysis of Human Bocavirus 1 Transcripts in Infected Human Airway Epithelium

Viruses, 2019
Human bocavirus 1 (HBoV1) infects well-differentiated (polarized) human airway epithelium (HAE) cultured at an air-liquid interface (ALI). In the present study, we applied next-generation RNA sequencing to investigate the genome-wide transcription ...
Wei Zou, Min Xiong, Xuefeng Deng, John F. Engelhardt, Ziying Yan, Jianming Qiu   +5 more
doaj   +1 more source