Results 71 to 80 of about 66,094 (222)
Functions for S. cerevisiae Swd2p in 3' end formation of specific mRNAs and snoRNAs and global histone 3 lysine 4 methylation [PDF]
, 2004 The Saccharomyces cerevisiae WD-40 repeat protein Swd2p associates with two functionally distinct multiprotein complexes: the cleavage and polyadenylation factor (CPF) that is involved in pre-mRNA and snoRNA 3' end formation and the SET1 complex (SET1C ...
Aasland, R., Dichtl, B., Keller, W.
core
, 2013 Shown is a schematic view of the 6570 bp long PEG10 transcript with a poly-A tail at its 3′-end. Shown is also the PEG10 mRNA 3′-end sequence with the two underlined canonical polyadenylation signal motifs.
Heiko Flammann (367928) +3 more
core +1 more source
RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging
Biological Reviews, EarlyView.ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad +5 more
wiley +1 more source
Recognition of polyadenylation sites in yeast pre‐mRNAs by cleavage and polyadenylation factor [PDF]
The EMBO Journal, 2001 Recognition of poly(A) sites in yeast pre-mRNAs is poorly understood. Employing an in vitro cleavage system with cleavage and polyadenylation factor (CPF) and cleavage factor IA we show that the efficiency and positioning elements are dispensable for poly(A)-site recognition within a short CYC1 substrate in vitro.
Dichtl, B., Keller, W.
openaire +4 more sources
Status and future of recombinant adeno‐associated virus vector manufacturing
Biotechnology Progress, EarlyView.Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley +1 more source
Evaluation of a novel, short polyA signal from the Bombyx mori bidensovirus
Invertebrate Survival Journal, 2017 Bombyx mori bidensovirus (BmBDV) is the only virus which belongs to the new Bidnaviridae family established by the International Committee on Taxonomy of Viruses in 2012.
M Wang +7 more
doaj
Benchmarking sequencing methods and tools that facilitate the study of alternative polyadenylation
Genome Biology, 2021 Background Alternative cleavage and polyadenylation (APA), an RNA processing event, occurs in over 70% of human protein-coding genes. APA results in mRNA transcripts with distinct 3′ ends.
Ankeeta Shah +3 more
doaj +1 more source
Cytoskeleton, EarlyView.ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith +9 more
wiley +1 more source
Analysis Polyadenylation Signal Usage in Sus scrofa
, 2022 RNA polyadenylation is an important step in the messenger RNA (mRNA) maturation process, and the first step is recognizing the polyadenylation signal (PAS).
Min Zhang +3 more
core +1 more source
eLife, 2017 3’ polyadenylation is a key step in eukaryotic mRNA biogenesis. In mammalian cells, this process is dependent on the recognition of the hexanucleotide AAUAAA motif in the pre-mRNA polyadenylation signal by the cleavage and polyadenylation specificity ...
Marcello Clerici +3 more
doaj +1 more source