Results 81 to 90 of about 66,094 (222)

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Sequence determinants in human polyadenylation site selection [PDF]

, 2003
Background Differential polyadenylation is a widespread mechanism in higher eukaryotes producing mRNAs with different 3' ends in different contexts. This involves several alternative polyadenylation sites in the 3' UTR, each with its specific strength ...
Gautheret, Daniel, Gautheret Daniel, Matthieu Legendre, Daniel Gautheret, Legendre, Matthieu, Legendre Matthieu   +5 more
core   +2 more sources

Aurora kinase A is not involved in CPEB1 phosphorylation and cyclin B1 mRNA polyadenylation during meiotic maturation of porcine oocytes. [PDF]

PLoS ONE, 2014
Regulation of mRNA translation by cytoplasmic polyadenylation is known to be important for oocyte maturation and further development. This process is generally controlled by phosphorylation of cytoplasmic polyadenylation element binding protein 1 (CPEB1).
Pavla Komrskova, Andrej Susor, Radek Malik, Barbora Prochazkova, Lucie Liskova, Jaroslava Supolikova, Stepan Hladky, Michal Kubelka   +7 more
doaj   +1 more source

RNA degradomics and proteomics reveal the mechanism of dsProsβ1‐mediated proteasome targeting in Psylliodes chrysocephala

Pest Management Science, EarlyView.
RNA degradomics revealed dsProsβ1‐derived siRNA‐mediated mRNA cleavage events, mainly at uracil‐guanine and adenine‐adenine pairs. Proteasome inhibition via dsProsβ1 increased mitochondrial and cytoskeletal proteins while reducing translation‐related and mRNA‐binding proteins.
Doga Cedden, Gözde Güney, Michael Rostás, Stefan Scholten   +3 more
wiley   +1 more source

Polyadenylation: A tail of two complexes [PDF]

Current Biology, 2002
Recent studies have uncovered new connections between the enzymes of mRNA 3' end processing and RNA polymerase II. These connections improve the efficiency of polyadenylation and signal to the polymerase to terminate transcription; their discovery reveals another level of gene regulation.
Proudfoot, Nick, O'Sullivan, Justin
openaire   +2 more sources

Regulation of alternative polyadenylation by genomic imprinting [PDF]

, 2008
Maternally and paternally derived alleles can utilize different promoters, but allele-specific differences in cotranscriptional processes have not been reported.
Schulz, Reiner, Peters, Jo, Bourc'his, Deborah, Woodfine, Kathryn, Beechey, Colin V, Woodfine, K, Koltowska, K, Oakey, Rebecca J., Oakey, Rebecca J, Koltowska, Katarzyna, Oakey, R J; id_orcid, Beechey, Colin V., Schulz, R, Peters, J, Bourc'his, D, Wood, Andrew, Wood, A J, Beechey, C V, Wood, Andrew J.   +18 more
core   +1 more source

Transposons as Tools for Future Genome Engineering in Yeasts and Filamentous Fungi

Yeast, EarlyView.
Applications of transposon‐based tools for genome engineering in fungi include transposon‐mediated mutagenesis and targeted genomic integration. ABSTRACT Transposons are fundamental genetic elements that have profoundly shaped the architecture of eukaryotic genomes.
Bingyin Peng, Masahiro Tominaga, Chengqiang Wang, Robert E. Speight, Jun Ishii   +4 more
wiley   +1 more source

Maturation of selected human mitochondrial tRNAs requires deadenylation

eLife, 2017
Human mitochondria contain a genome (mtDNA) that encodes essential subunits of the oxidative phosphorylation system. Expression of mtDNA entails multi-step maturation of precursor RNA. In other systems, the RNA life cycle involves surveillance mechanisms,
Sarah F Pearce, Joanna Rorbach, Lindsey Van Haute, Aaron R D’Souza, Pedro Rebelo-Guiomar, Christopher A Powell, Ian Brierley, Andrew E Firth, Michal Minczuk   +8 more
doaj   +1 more source

Yeast Knockout Strain Collection: Driving Functional Genomics, Biotechnological Applications and Human Disease Research

Yeast, EarlyView.
ABSTRACT The knockout strain collection of Saccharomyces cerevisiae has served as a valuable resource for functional genomics and yeast‐based biotechnology studies. A comprehensive single‐gene knockout strain collection, covering nearly all non‐essential genes, together with complementary mutant collections for essential genes, including temperature ...
Takashi Hirasawa
wiley   +1 more source

Translação local de mRNAs em sindrome de Down [PDF]

, 2011
Mestrado em Biologia AplicadaO Síndrome de Down (DS) é a causa genética mais frequente de atraso mental. À semelhança de outros síndromes em que ocorrem deficiências em termos de memória e aprendizagem, as anomalias em especial ao nível das espinhas ...
Rodrigues, Carina Teresa dos Santos
core