Results 101 to 110 of about 462,629 (365)

Management of Calvarial Osteoradionecrosis After Treatment of Cutaneous Malignancy: A Systematic Review

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Osteoradionecrosis (ORN) is a recognized complication of radiotherapy. However, calvarial ORN (ORNC) following treatment for cutaneous malignancies is poorly understood. Shedding light on the limited evidence to date, this study aims to summarize existing evidence and highlight the research gaps.
Siyuan Pang, Elizabeth Concannon, Martin Higgins, Katharine Drummond, Peter Gearing, Maxim Devine, Albert Tiong, Anand Ramakrishnan, Carly Fox   +8 more
wiley   +1 more source

Proximal Tubulopathy With Fibrillary Inclusions: A Rare Manifestation of Lymphoma-Associated Monoclonal Gammopathy of Renal Significance (MGRS)

Kidney Medicine, 2019
Light chain proximal tubulopathy is a rare M-proteinemia–related nephropathy. The inclusions, composed of light chains in light chain proximal tubulopathy, are generally crystalline, and most exhibit a rhombic shape.
Ayami Ino, Kanoko Yamaguchi, Sekiko Taneda, Shiho Makabe, Yoshie Wakayama, Hiroshi Kataoka, Junji Tanaka, Kosaku Nitta, Toshio Mochizuki   +8 more
doaj  

Dissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways

Communications Biology, 2018
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder caused by loss-of-function mutations in PKD1 or PKD2. Increased glycolysis is a prominent feature of the disease, but how it impacts on other metabolic pathways is unknown.
C. Podrini, I. Rowe, R. Pagliarini, Ana S. H. Costa, M. Chiaravalli, Ivano Di Meo, Hyunho Kim, Gianfranco Distefano, V. Tiranti, F. Qian, D. di Bernardo, C. Frezza, A. Boletta   +12 more
semanticscholar   +1 more source

Centrosome amplification disrupts renal development and causes cystogenesis [PDF]

, 2018
International ...
Amanda Knoten, Arquint, Astrinidis, Battini, Bettencourt-Dias, Bhaskar, Boehlke, Boletta, Brito, Brown, Burtey, Chang-Panesso, Chen, Chi, Coelho, Cosenza, Davenport, Dere, Distefano, Fisher, Ganem, Godinho, Godinho, Godinho, Goto, Habedanck, Hartman, Hendry, Hoshi, Jain, Jain, Janssen, Jinzhi Wang, Jonassen, Keefe Davis, Kobayashi, Krämer, Kulukian, Kyuhwan Shim, Lai Kuan Dionne, Levine, Lin, Ma, Mahjoub, Majumdar, Marthiens, Marthiens, Masato Hoshi, Masyuk, Moe R. Mahjoub, Mugford, Mundlos, Nano, Nigg, Nigg, Ogden, Patel, Quintyne, Renata Basto, Roselli, Saifudeen, Saifudeen, Sanjay Jain, Schmidt-Ott, Serçin, Shao, Sharma, Shillingford, Silkworth, Sillibourne, Simons, Srivastava, Takakura, Tammachote, Tao Cheng, Veronique Marthiens, Vitre, Werner, Yoder, Zhao   +79 more
core   +5 more sources

Nanozymes in Reactive Oxygen Species‐Dependent Diseases: From Design and Preclinical Studies to Clinical Translation Prospects

Small Structures, EarlyView.
Nanozymes emerge as promising therapeutic agents for reactive oxygen species (ROS)‐dependent diseases, offering advantages over traditional biocatalysts through enhanced stability, tunability, and targeting capabilities. This review explores their mechanisms, design strategies, and clinical progress, emphasizing precision medicine potential.
Lihong Zhou, Jingyu Yan, Chenying Cui, Yurong Xu, Kaifang Zhang, Meijun Du, Zhuowei Zhang, Xiuping Wu, Bing Li   +8 more
wiley   +1 more source

Mitochondrial Abnormality Facilitates Cyst Formation in Autosomal Dominant Polycystic Kidney Disease

Molecular and Cellular Biology, 2017
Autosomal dominant polycystic kidney disease (ADPKD) constitutes the most inherited kidney disease. Mutations in the PKD1 and PKD2 genes, encoding the polycystin 1 and polycystin 2 Ca2+ ion channels, respectively, result in tubular epithelial cell ...
Y. Ishimoto, R. Inagi, D. Yoshihara, M. Kugita, S. Nagao, A. Shimizu, Norihiko Takeda, Masaki Wake, K. Honda, Jing Zhou, M. Nangaku   +10 more
semanticscholar   +1 more source

Structural and molecular basis of the assembly of the TRPP2/PKD1 complex [PDF]

, 2009
Mutations in PKD1 and TRPP2 account for nearly all cases of autosomal dominant polycystic kidney disease (ADPKD). These 2 proteins form a receptor/ion channel complex on the cell surface. Using a combination of biochemistry, crystallography, and a single-
Buraei, Z., Chen, X.Z., Isacoff, E.Y., Li, M.H., Ong, A.C.M., Tong, L., Ulbrich, M., Yang, J., Yu, Y.   +8 more
core   +3 more sources

Performance of international phenotypic criteria for prenatal exome sequencing: systematic review and comparative diagnostic accuracy study using historical individual participant data

Ultrasound in Obstetrics &Gynecology, EarlyView.
ABSTRACT Objectives To evaluate: (i) the performance of the National Health Service (NHS) phenotypic eligibility criteria for prenatal exome sequencing (pES); (ii) the diagnostic yield of individual NHS criteria; (iii) the diagnostic yield when one or multiple NHS criteria were met; and (iv) the performance of the NHS criteria compared with that of ...
K. Reilly, D. L. Rolnik, S. Allen, A. Sotiriadis, S. Ong, S. Sonner, G. V. Blayney, M. Fernando, T. van Mieghem, A. Borrell, S. Langlois, F. Mone, Collaborators, A. Khalil, U. Agarwal, S. Nanda, K. W. Choy, Y. Yaron, R. J. Martinez‐Portilla, F. R. Grati, E. Westenius, E. Iwarsson, K. O. Kagan, R. Pooh   +23 more
wiley   +1 more source

Tuberous sclerosis associated with autosomal dominant polycystic kidney disease: Case report about of the TSC2/PKD1 contiguous gene syndrome

Medicina, 2016
We present a case of a young woman with chronic kidney disease, with a history of seizures, episodes of spontaneous pneumothorax and left nephrectomy. The retrospective study of the image exams showed liver, kidney and lung cysts; in addition to cortical
Rodolfo M. Queiroz, Michela P. Gomes, Marcus V. N. Valentin, Cecília H. Miyake, Lucas G. Abud, Marcio de Castro e Silva   +5 more
doaj   +1 more source

Giant hydronephrosis: A rare cause of secondary hypertension

UroPrecision, EarlyView.
Abstract Background Hypertension secondary to giant hydronephrosis (GH) is a rare but treatable renal condition mediated by the renin‐angiotensin‐aldosterone system and tubuloglomerular feedback. In adults, GH is often diagnosed late due to nonspecific abdominal symptoms that may not manifest until advanced stages.
Ganesh Laxman Krishnamurthy, Arun Chawla, Sunil Pillai Bhaskara, Padmaraj Hegde, Ankit Agarwal, Vijay Gunashekar, Arghya Choudhuri, Aishwarya Tinaikar   +7 more
wiley   +1 more source