Results 111 to 120 of about 5,227,561 (214)

SIRT3‐Dependent Actions of Berberine: From Molecular Therapies to Toxicity

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
This study reveals that berberine's therapeutic versatility in metabolic, cardiovascular, and hepatic disorders stems from its modulation of the mitochondrial protein Sirt3. Understanding this mechanism explains both its broad efficacy and its organ‐specific toxicity, positioning berberine as a promising mitochondrial epigenetic modulator whose ...
Dareuosh Shackebaei, Seyed Shahram Miraghaee, Faegheh Farhadi, Abolfazl Akbarzadeh, Fatemeh Yarmohammadi   +4 more
wiley   +1 more source

Hypertriglyceridemia: Causes, Consequences, Diagnosis, and Management

MedComm, Volume 7, Issue 10, October 2026.
Hypertriglyceridemia (HTG) arises from the interplay between genetic susceptibility and secondary or precipitating factors, leading to dysregulated triglyceride‐rich lipoprotein (TRL) metabolism. Increased TRL production and impaired clearance promote distinct risk phenotypes: accumulation of apolipoprotein B(apoB)‐containing TRL remnants contributes ...
Shanshan Qi, Weiwei Chen, Kunhao Chen, Song Yang, Sibo Wang, Tongtian Ni, Dan Xu, Enqiang Mao, Erzhen Chen, Ying Chen   +9 more
wiley   +1 more source

Organoids: Current Applications and Future Directions

MedComm, Volume 7, Issue 10, October 2026.
Organoids are three‐dimensional multicellular structures derived from stem cells or primary tissues that recapitulate key structural and functional features of native organs. Advances in stem cell biology, biomaterials, and bioengineering have established organoids as powerful platforms for studying human development and disease mechanisms, drug ...
Yueqi Leng, Yue Wang, Canhui Cao, Feng Deng, Weisi Lian, Xingtong Chen, Mingmei Lin, Zhonghong Zeng, Dan Mo, Shangqi Li, Yilei He, Yang Yu, Heng Pan, Ping Zhou, Rong Li   +14 more
wiley   +1 more source

Rationale and design of the TEMPO (Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and its Outcomes) 3-4 Study.

, 2011
Current management of autosomal dominant polycystic kidney disease (ADPKD) is focused on treating disease complications, not on slowing cyst development or preventing progression to kidney failure.
Grantham, Jared J., Vicente E. Torres, Torres, Vicente E., Meijer, Esther, Eiji Higashihara, Kyongtae T. Bae, Olivier Devuyst, Ronald D. Perrone, Chapman, Arlene B., Krasa, Holly B., Higashihara, Eiji, John J. Ouyang, Perrone, Ronald D., Esther Meijer, Ouyang, John J., Bae, Kyongtae T., Jared J. Grantham, Arlene B. Chapman, Devuyst, Olivier, Ron T. Gansevoort, Gansevoort, Ron T., Czerwiec, Frank S., Holly B. Krasa, Frank S. Czerwiec   +23 more
core   +1 more source

Giant thrombus entrapped by a patent foramen ovale in a patient with polycystic kidney disease

Clinical and Biomedical Research, 2017
Polycystic kidney disease (PKD) is the most common genetic cause of chronic kidney disease (CKD). The most common cause of death in patients with this condition is cardiovascular disease, mainly due to hypertension and its consequences.
Gustavo Neves de Araujo, Stéfani Mariani, Felipe Pereira Lima Marques, Lucas Simonetto Faganello, Luís Henrique Klafke, Douglas Dal Más Freitas, Solano Berger   +6 more
doaj   +2 more sources

Iron and Other Metal Ions in Human Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley   +1 more source

Polycystic kidney and Down Syndrome

Journal of Research in Medical Sciences, 2006
Kidney disease is not a common complication in Down Syndrome (DS). A variety of renal and urologic problems have been described in these patients and some develop renal failure. Coincidence of polycystic kidney disease and DS is a rare entity.
Azar Nickavar
doaj  

FLCN Multi‐Exon Deletion in a Chihuahua With Renal Cysts and Nodular Dermatofibrosis

Animal Genetics, Volume 57, Issue 5, October 2026.
Melvin Schneiter, Julie Selz, Jacky Jonker, Martina Dettwiler, Vidhya Jagannathan, Tosso Leeb, Elisa Maina   +6 more
wiley   +1 more source

Quantitative Susceptibility Mapping of Kidney Stones: An Ex Vivo MRI Phantom Study

Magnetic Resonance in Medicine, Volume 96, Issue 4, Page 1846-1859, October 2026.
ABSTRACT Purpose To visualize and characterize the five most common kidney stone types based on their magnetic susceptibilities in MRI using QSM. Methods Three water‐based agar phantoms were constructed, containing a total of 53 ex vivo kidney stones of varying types and sizes.
Lion H. Mücke, Frederik B. Laun, Ruben de Figueiredo Cardoso, Guillaume Flé, Jennifer Lorenz, Alexander Fichte, Michael Uder, Nadine Bayerl, Jannis Hanspach   +8 more
wiley   +1 more source