Results 131 to 140 of about 5,227,561 (214)

Association of Three HIF‐1α Genotypes With Susceptibility and Severity of Chronic Kidney Disease

Clinical and Translational Science, Volume 19, Issue 10, October 2026.
ABSTRACT Hypoxic signaling is a critical factor in the pathogenesis of Chronic Kidney Disease (CKD). Hypoxia‐Inducible Factor 1 (HIF‐1) is a transcription factor that is highly expressed in the kidney and is associated with renal tubular hypoxic adaptation. Variation in the HIF‐1α subunit gene has been associated with renal pathologies.
Hanifa Aktar, Shahrzad Ashena, Mohammad Sanaei Ardekani, Shahrzad Movafagh   +3 more
wiley   +1 more source

The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation

The FEBS Journal, Volume 293, Issue 19, Page 5717-5734, October 2026.
The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak, In‐Ja L. Byeon, Ryan Ponticelli, Mary E. Lucas, Lariah Thompson, Christopher DeHaven, Gary Thomas, Angela M. Gronenborn   +7 more
wiley   +1 more source

Coronary aneurysms and dissections in a patient with autosomal dominant polycystic kidney disease: a case report

Journal of Medical Case Reports
Background Autosomal dominant polycystic kidney disease is the most common hereditary kidney disorder, characterized by the progressive formation of renal cysts due to genetic mutations.
Maria Júlia Carnieletto Nicolodi, Gustavo Carnieletto Garcia, Md. José Knopfholz   +2 more
doaj   +1 more source

UltRaSoUnd‐guided evaLuAtion of metabolic health in a cohort of midlife women with HIV: The URSULA study

HIV Medicine, Volume 27, Issue 10, Page 1650-1662, October 2026.
Abstract Objectives We aimed to determine the prevalence of metabolic disorders, liver steatosis and metabolic dysfunction‐associated steatotic liver disease (MASLD) in a cohort of middle‐aged women with HIV (WoWH) and to explore associations between liver steatosis, visceral fat depots and carotid atherosclerosis.
Mariacristina Poliseno, Davide Capruzzi, Antonio Cianciaruso, Nicola Colavito, Felicia Dalitto, Vincenzo Giliberti, Vittoria Lobalsamo, Giuliana Metrangolo, Marica Noviello, Alessandra Vigna, Maurizio Zarcone, Francesco Di Gennaro, Vincenzo Ostilio Palmieri, Annalisa Saracino   +13 more
wiley   +1 more source

Soluble Immune Checkpoints and Anti‐HLA Antibodies in Kidney Transplant Recipients: Associations With Kidney Function

Immunology, Volume 179, Issue 2, Page 269-286, October 2026.
Soluble immune checkpoints, anti‐HLA panel‐reactive antibodies, and kidney function parameters were evaluated to investigate their associations with early graft function. Pre‐transplant patients showed higher levels of sCD25, sPD‐L1, sTIM‐3, Gal‐9, sCD27, and sPD‐L2 than healthy controls, while post‐transplant temporal changes were observed in sCD25 ...
Cemil Pehlivanoğlu, Fırat Demircan, Başak Aru, Süheyla Apaydın, Abdullah Demir, Rabia Tığlı, Gürkan Tellioğlu, Ali Osman Gürol, Gülderen Yanıkkaya Demirel   +8 more
wiley   +1 more source

Clinical Decision Support for Adult Enteral Nutrition: Literature Overview and Preliminary Hospital‐Based Evaluation

Journal of Evaluation in Clinical Practice, Volume 32, Issue 7, October 2026.
ABSTRACT Rationale Clinical Decision Support Systems (CDSS) are increasingly used to enhance medical decision‐making, including nutrition support. Objective This study aimed to narratively review CDSS tools for enteral nutrition (EN) and to preliminarily evaluate a locally developed internal‐use CDSS designed to calculate patients' nutritional ...
Panos Papandreou, Alexandra Foscolou, Aristea Gioxari, Paraskevi Detopoulou   +3 more
wiley   +1 more source

Kidney: Polycystic Disease

, 1900
Polycystic disease, liver and ...
MUSC Department of Pathology and Laboratory Medicine
core  

Divergent effects of hyperandrogenemia on the female reproductive neuroendocrine axis under different physiological conditions

Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.
Abstract The hypothalamic–pituitary–gonadal (HPG) axis coordinates reproductive function and incorporates gonadal sex steroid feedback to regulate gonadotropin secretion in a homeostatic manner. In females, ovarian estrogens and progestins act as the primary negative feedback signals to suppress luteinizing hormone (LH) release, whereas in males ...
Lillian Rose, Alexander S. Kauffman
wiley   +1 more source

Upcoming therapies for steatotic liver disease: Translating breakthroughs into clinical practice

Journal of Internal Medicine, Volume 300, Issue 4, Page 440-460, October 2026.
Abstract Metabolic dysfunction‐associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide and a leading cause of cirrhosis, hepatocellular carcinoma, and cardiometabolic morbidity. Often clinically silent until advanced fibrosis develops, management has largely relied on lifestyle interventions, with limited ...
Philip N. Newsome, Saima Ajaz
wiley   +1 more source

Contributions of the anion exchangers SLC26A1, SLC26A2, SLC26A3, and SLC26A6 to intestinal oxalate transport in human Caco2‐BBE cells

Physiological Reports, Volume 14, Issue 19, October 2026.
Abstract Kidney stones affect ~1 in 5 men and 1 in 11 women, with 70%–80% being composed of calcium oxalate. Knowing the contributions of anion exchangers SLC26A2 (A2), A3, and A6 to apical and A1 to basolateral oxalate transport in human intestinal Caco2‐BBE (C2) cells is important since enhancing intestinal oxalate secretion (A6/2/?A1) and reducing ...
Khalid A. Abdelhalim, Donna Arvans, Yanzhe Wang, Mohamed Elfatih H. Bashir, Hatim A. Hassan   +4 more
wiley   +1 more source