Results 151 to 160 of about 462,629 (365)

Myotonic dystrophy and polycystic disease of the kidneys. [PDF]

, 1967
Alan E H Emery, S. Oleesky, Randy Williams   +2 more
openalex   +1 more source

Patterns of Kidney Function Decline in Autosomal Dominant Polycystic Kidney Disease: A Post Hoc Analysis From the HALT-PKD Trials.

American Journal of Kidney Diseases, 2018
BACKGROUND Previous clinical studies of autosomal dominant polycystic kidney disease (ADPKD) reported that loss of kidney function usually follows a steep and relentless course.
G. Brosnahan, Kaleab Z. Abebe, C. Moore, F. Rahbari-Oskoui, K. Bae, J. Grantham, R. Schrier, W. Braun, A. Chapman, M. Flessner, P. Harris, M. Hogan, R. Perrone, D. Miskulin, T. Steinman, V. Torres   +15 more
semanticscholar   +1 more source

Lactate and Lactylation in AKI‐to‐CKD: Epigenetic Regulation and Therapeutic Opportunities

Cell Proliferation, EarlyView.
ABSTRACT Lactate is not only a byproduct of glycolysis, but is also considered an energy source, gluconeogenic precursor, signalling molecule and protein modifier during the process of cellular metabolism. The discovery of lactylation reveals the multifaceted functions of lactate in cellular metabolism and opens new avenues for lactate‐related research.
Yi Hou, Dongwei Liu, Zuishuang Guo, Cien Wei, Fengyu Cao, Yue Xu, Qi Feng, Fengxun Liu   +7 more
wiley   +1 more source

Grayscale ultrasound characteristics of autosomal dominant polycystic kidney disease severity – an adult and pediatric cohort study

Journal of Ultrasonography, 2017
Introduction: The most common hereditary kidney condition is autosomal dominant polycystic kidney disease. It is the cause of 5–10% of end-stage renal disease.
Marcin Strzelczyk, Michał Podgórski, Susan Afshari, Marcin Tkaczyk, Monika Pawlak-Bratkowska, Piotr Grzelak   +5 more
doaj   +1 more source

Imaging classification of autosomal dominant polycystic kidney disease: a simple model for selecting patients for clinical trials.

Journal of the American Society of Nephrology, 2015
The rate of renal disease progression varies widely among patients with autosomal dominant polycystic kidney disease (ADPKD), necessitating optimal patient selection for enrollment into clinical trials.
M. Irazabal, L. Rangel, E. Bergstralh, Sara L. Osborn, Amber J Harmon, J. L. Sundsbak, K. Bae, A. Chapman, J. Grantham, M. Mrug, M. Hogan, Z. El-Zoghby, P. Harris, B. Erickson, B. King, V. Torres   +15 more
semanticscholar   +1 more source

Foetal disruptive brain injuries: Diagnosing the underlying pathogenetic mechanisms with cranial ultrasonography

Developmental Medicine &Child Neurology, EarlyView.
Abstract Antenatal destructive events affecting the central nervous system of the foetus lead to disruptive brain lesions that are often associated with impaired neurodevelopment. The pathogenesis of these lesions encompasses a range of causes, including haemorrhagic, embolic, or other vascular events; exposure to teratogens, such as drugs or substance
Ana Alarcón, Nuria Carreras, Tobias Muehlbacher, Dídac Casas‐Alba, Roberta Arena, Paola Roca‐Llabrés, Juan Navarro‐Morón, Linda S. de Vries, Paul Govaert, the EurUS.Brain group, Thais Agut, Roberta Arena, Ana Alarcón, Juan Arnáez, Marco Bartocci, Isabel Benavente‐Fernández, María Carmen Bravo, Fernando Cabañas, Nuria Carreras, Olivier Claris, Jeroen Dudink, Monica Fumagalli, Alfredo García‐Alix, Paul Govaert, Sandra Horsch, Simón Lubián, Tobias Muehlbacher, Alessandro Parodi, Adelina Pellicer, Luca Ramenghi, Charles C. Roehr, Simone Schwarz, Sylke Steggerda, Eva Valverde   +33 more
wiley   +1 more source

Polycystic Kidney Disease without an Apparent Family History.

Journal of the American Society of Nephrology, 2017
The absence of a positive family history (PFH) in 10%-25% of patients poses a diagnostic challenge for autosomal dominant polycystic kidney disease (ADPKD).
Ioan-Andrei Iliuta, Vinusha Kalatharan, Kairong Wang, E. Cornec-Le Gall, J. Conklin, M. Pourafkari, Ryan R. Ting, Chen Chen, A. Borgo, N. He, Xuewen Song, C. M. Heyer, Sarah R. Senum, Y. Hwang, A. Paterson, P. Harris, K. Khalili, Y. Pei   +17 more
semanticscholar   +1 more source

Stem cells and fluid flow drive cyst formation in an invertebrate excretory organ.

, 2015
Cystic kidney diseases (CKDs) affect millions of people worldwide. The defining pathological features are fluid-filled cysts developing from nephric tubules due to defective flow sensing, cell proliferation and differentiation.
Alexander, R., Alvarado, A., Lakshmanaperumal, N., McClain, M., McKinney, S., Rink, J., Vu, H.   +6 more
core   +1 more source

Developments in albuminuria testing: A key biomarker for detection, prognosis and surveillance of kidney and cardiovascular disease—A practical update for clinicians

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Albuminuria, the abnormal presence of albumin in urine, is a key marker of kidney damage and a strong predictor of kidney and cardiovascular outcomes. Its clinical significance has evolved from early historical observations to its current role in chronic kidney disease (CKD) detection, risk stratification and treatment monitoring.
Jelle M. Beernink, Dominique van Mil, Gozewijn D. Laverman, Hiddo J. L. Heerspink, Ron T. Gansevoort   +4 more
wiley   +1 more source

Giant thrombus entrapped by a patent foramen ovale in a patient with polycystic kidney disease

Clinical and Biomedical Research, 2017
Polycystic kidney disease (PKD) is the most common genetic cause of chronic kidney disease (CKD). The most common cause of death in patients with this condition is cardiovascular disease, mainly due to hypertension and its consequences.
Gustavo Neves de Araujo, Stéfani Mariani, Felipe Pereira Lima Marques, Lucas Simonetto Faganello, Luís Henrique Klafke, Douglas Dal Más Freitas, Solano Berger   +6 more
doaj   +2 more sources