Results 191 to 200 of about 488,068 (360)

Wnt Signaling Pathway: Biological Function, Diseases, and Therapeutic Interventions

MedComm, Volume 7, Issue 1, January 2026.
The Wnt signaling pathway is essential for development and tissue homeostasis, while its dysregulation drives diverse diseases. This review systematically outlines its components, functions, regulators, and preclinical models, highlighting secreted frizzled‐related proteins (SFRPs) as context‐dependent, biphasic modulators.
Xiaoyu Jin, Jiahui Wang, Runyi Cao, Dongsheng Jiang   +3 more
wiley   +1 more source

Modifiers of Autosomal Dominant Polycystic Kidney Disease Severity: The Role of PKD1 Hypomorphic Alleles [PDF]

, 2023
Enrico Ambrosini, Francesca Montanari, Carlotta Pia Cristalli, Irene Capelli, Claudio La Scola, Andrea Pasini, Claudio Graziano   +6 more
openalex   +1 more source

Prenatal Exome Sequencing Analysis in Fetuses With Structural Anomalies: A Multicenter Prospective Cohort Study With Practical Implications

Prenatal Diagnosis, Volume 46, Issue 1, Page 46-55, January 2026.
ABSTRACT Objective To evaluate the diagnostic value of prenatal exome sequencing (ES) integrated with copy number variant (CNV) and single nucleotide variant (SNV) analysis (ES‐CNV/SNV) in fetuses with structural anomalies following negative chromosomal microarray analysis (CMA) and karyotyping, and to delineate the practical challenges encountered ...
Yulin Jiang, Haibo Li, Xiangyu Zhu, Liangpu Xu, Ying Chang, Fengqun Dong, Jianping Xiao, Jian Gao, Minyue Dong, Ying Peng, Hua Jin, Ting Wang, Xiaoxiao Xie, Lin Zhang, Hongmei Zhuang, Na Hao, Xiya Zhou, Hongna Wang, Ying You, Kun Ma, Rui Xiao, Qingwei Qi   +21 more
wiley   +1 more source

Impact of Anesthesia Strategy on Infant Pulmonary Function Test Quality and Duration

Pediatric Pulmonology, Volume 61, Issue 1, January 2026.
ABSTRACT Introduction While chloral hydrate (CH) has been standard for infant pulmonary function testing (iPFT) sedation, CH shortages are necessitating use of different sedation approaches. We aimed to compare the safety, test duration, and test quality of alternative sedation strategies for iPFT.
Aditi K. Zaveri, Brian Yoho, Brian Blasiole, Erick Forno, Daniel J. Weiner, Kristina Gaietto   +5 more
wiley   +1 more source

The impact of chronic kidney disease on arteriovenous fistula remodeling: studies in a murine model of autosomal dominant polycystic kidney disease [PDF]

Suzanne Laboyrie, Dorien J.M. Peters, Roel Bijkerk, Eduard Pierre de Winter, Jacques M.G.J. Duijs, Juliette A. de Klerk, Margreet R. de Vries, Joris I. Rotmans   +7 more
openalex   +1 more source

Autosomal dominant polycystic kidney disease—type 2. Ultrasound, genetic and clinical correlations [PDF]

, 2000
Kyproulla Demetriou, Chrysa Tziakouri, Kristiana Anninou, Andri Eleftheriou, Michalis Koptides, Alexia Nicolaou, Constantinos Deltas, Alkis Pierides   +7 more
openalex   +1 more source

Optimizing Maternal Microbiome: Role in Improved Conception and Pregnancy Outcome

Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.
Maternal microbiome optimization: Minimized risk and simple corrective steps. ABSTRACT Purpose To evaluate the role of optimizing the maternal microbiome in improving pregnancy outcomes, focusing on preconception and early gestation, and to propose practical diagnostic and preventive strategies, particularly in low‐ and middle‐income countries (LMIC ...
Eytan R. Barnea, Amala Nazareth, Chittaranjan N. Purandare, Anderson Pinheiro‐Borovac, Ruth Dolmo Carluccio, Nikhil C. Purandare, Fionnuala M. McAuliffe, FIGO Reproductive Endocrinology and Infertility Committee Members   +7 more
wiley   +1 more source

Polycystic kidney disease

Kidney International, 1982
openaire   +2 more sources

Renin‐angiotensin System Activation in Congenital Hepatic Fibrosis in the PCK Rat Model of Autosomal Recessive Polycystic Kidney Disease

, 2010
Miwa Goto, Nita Hoxha, Rania Osman, Jessica Wen, Rebecca G. Wells, Katherine MacRae Dell   +5 more
openalex   +1 more source

Liver Failure in Advanced Adult-onset Polycystic Kidney Disease [PDF]

, 2018
Christina Awad, Grant Gardner Gallimore
openalex   +1 more source