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Polycystic kidney disease [PDF]

Nature Reviews Disease Primers, 2018
Cystic kidneys are common causes of end-stage renal disease, both in children and in adults. Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD) are cilia-related disorders and the two main forms of monogenic cystic kidney diseases.
Bergmann, C., Guay-Woodford, L.M., Harris, P.C., Horie, S., Peters, D.J.M., Torres, V.E.   +5 more
semanticscholar   +8 more sources

Vascular Endothelial Growth Factor C for Polycystic Kidney Diseases.

J Am Soc Nephrol, 2016
Polycystic kidney diseases (PKD) are genetic disorders characterized by progressive epithelial cyst growth leading to destruction of normally functioning renal tissue.
Huang JL, Woolf AS, Kolatsi-Joannou M, Baluk P, Sandford RN, Peters DJ, McDonald DM, Price KL, Winyard PJ, Long DA.   +9 more
europepmc   +2 more sources

MicroRNAs and Polycystic Kidney Disease [PDF]

Kidney Medicine, 2020
Important advances have been made regarding the diagnosis and management of polycystic kidney diseases. Care of patients with polycystic kidney diseases has moved beyond supportive care for complications and chronic kidney disease to new potentially disease-modifying therapies.
Dantong Li, Liangzhong Sun
openaire   +5 more sources

Insights Into the Molecular Mechanisms of Polycystic Kidney Diseases. [PDF]

Front Physiol, 2021
Autosomal dominant (AD) and autosomal recessive (AR) polycystic kidney diseases (PKD) are severe multisystem genetic disorders characterized with formation and uncontrolled growth of fluid-filled cysts in the kidney, the spread of which eventually leads ...
Vasileva VY, Sultanova RF, Sudarikova AV, Ilatovskaya DV.   +3 more
europepmc   +2 more sources

Metabolomics Approaches for the Diagnosis and Understanding of Kidney Diseases

Metabolites, 2019
Diseases of the kidney are difficult to diagnose and treat. This review summarises the definition, cause, epidemiology and treatment of some of these diseases including chronic kidney disease, diabetic nephropathy, acute kidney injury, kidney cancer ...
Hayley Abbiss, Garth L. Maker, Robert D. Trengove   +2 more
doaj   +2 more sources

Apoptosis and loss of renal tissue in polycystic kidney diseases.

New England Journal of Medicine, 1995
BACKGROUND Polycystic kidney disease is characterized by the enlargement of renal cysts, interstitial fibrosis, and gradual loss of normal renal tissue in association with progressive deterioration of renal function.
David D. L. Woo
semanticscholar   +2 more sources

Autophagy in Chronic Kidney Diseases

Cells, 2019
Autophagy is a cellular recycling process involving self-degradation and reconstruction of damaged organelles and proteins. Current evidence suggests that autophagy is critical in kidney physiology and homeostasis.
Tien-An Lin, Victor Chien-Chia Wu, Chao-Yung Wang   +2 more
doaj   +2 more sources

Complications of polycystic kidney disease

Kidney International, 1997
A 33-year-old white man first presented to the Royal Infirmary Stirling, Scotland, 24 years ago with a history of recent-onset hematuria. Intravenous urography at that time showed a filling defect in the right kidney; a subsequent aortogram demonstrated a single simple cyst in the right kidney.
Michael L. Watson
openaire   +4 more sources

Polycystic kidney disease

Kidney International, 1982
Principal discussant Wadi N. Suki
openaire   +4 more sources

Rare Combination of Phenotypes of Karyomegalic Interstitial Nephritis and Autosomal Recessive Polycystic Kidney Disease in an Omani Child. [PDF]

Oman Med J
Autosomal recessive polycystic kidney disease is one of the most prevalent inherited cystic kidney diseases in infants and children, common in highly consanguineous societies such as Oman. Karyomegalic interstitial nephritis is a rare cause of hereditary
Al Alawi I, Al Shehhi M, Al Riyami MS, Al Kalbani N, Al Hosni A, Al Mimani A, Al Salmi I, Sayer JA.   +7 more
europepmc   +2 more sources