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Insights Into the Molecular Mechanisms of Polycystic Kidney Diseases [PDF]
Front Physiol, 2021 Autosomal dominant (AD) and autosomal recessive (AR) polycystic kidney diseases (PKD) are severe multisystem genetic disorders characterized with formation and uncontrolled growth of fluid-filled cysts in the kidney, the spread of which eventually leads ...
Valeriia Y Vasileva +3 more
semanticscholar +2 more sources
Pathophysiology of childhood polycystic kidney diseases: new insights into disease-specific therapy
Pediatric Research, 2013 Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD) are significant causes of morbidity and mortality in children and young adults. ADPKD, with an incidence of 1:400 to 1:1,000, affects more than
W. Sweeney, E. Avner
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American Journal of Kidney Diseases, 2020 The omission of outcomes that are of relevance to patients, clinicians and regulators across trials in autosomal dominant polycystic kidney disease (ADPKD) limits shared decision-making. The Standardized Outcomes in Nephrology - Polycystic Kidney Disease
Yeoungjee Cho +30 more
semanticscholar +1 more source
Polycystic kidney diseases: From molecular discoveries to targeted therapeutic strategies
Cellular and Molecular Life Sciences, 2007 .Polycystic kidney diseases (PKDs) represent a large group of progressive renal disorders characterized by the development of renal cysts leading to end-stage renal disease.
O. Ibraghimov-Beskrovnaya, N. Bukanov
semanticscholar +1 more source
Autophagy in Chronic Kidney Diseases
Cells, 2019 Autophagy is a cellular recycling process involving self-degradation and reconstruction of damaged organelles and proteins. Current evidence suggests that autophagy is critical in kidney physiology and homeostasis.
Tien-An Lin, V. Wu, Chao-Yung Wang
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Metabolomics Approaches for the Diagnosis and Understanding of Kidney Diseases
Metabolites, 2019 Diseases of the kidney are difficult to diagnose and treat. This review summarises the definition, cause, epidemiology and treatment of some of these diseases including chronic kidney disease, diabetic nephropathy, acute kidney injury, kidney cancer ...
H. Abbiss, G. Maker, R. Trengove
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Radiology, 2019 Kidney cysts can manifest as focal disease (simple and complex kidney cysts), affect a whole kidney (eg, multicystic dysplastic kidney or cystic dysplasia), or manifest as bilateral cystic disease (eg, autosomal recessive polycystic kidney disease [ARPKD]
C. Gimpel +17 more
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Early and Severe Polycystic Kidney Disease and Related Ciliopathies: An Emerging Field of Interest
Nephron, 2018 Early and severe forms of polycystic kidney disease (PKD) do already manifest during childhood or adolescence. They are characterized by enlarged kidneys and diminished renal function that prenatally may result in Potter’s oligohydramnios sequence ...
C. Bergmann
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American Journal of Neuroradiology, 2016 BACKGROUND AND PURPOSE: Autosomal dominant polycystic kidney disease is associated with an increased risk of intracranial aneurysms. Our purpose was to assess whether there is an increased risk during aneurysm coiling and clipping. MATERIALS AND METHODS:
M. Rozenfeld +5 more
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Ciliopathies and the Kidney: A Review.
American Journal of Kidney Diseases, 2020 Primary cilia are specialized sensory organelles that protrude from the apical surface of most cell types. Over the past two decades, they have been found to play important roles in tissue development and signal transduction, with mutations in ciliary ...
Dominique J. Mcconnachie +2 more
semanticscholar +1 more source