Results 121 to 130 of about 34,123 (218)

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, Volume 183, Issue 16, Page 5082-5101, August 2026.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

A novel frameshift variation of PKD1 in familial autosomal dominant polycystic kidney diseases: expanding the clinical phenotype and genetic spectrum of PKD1 disorders. [PDF]

BMC Med Genomics
Chen Q, Shi L, Zhu X.
europepmc   +1 more source

TREM2 in Macrophages Promotes Renal Fibrosis via Activation of β‐Catenin Signalling Pathway in Obstructive Nephropathy

Cell Proliferation, Volume 59, Issue 8, August 2026.
Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) promotes obstructive nephropathy progression by activating the β‐catenin signalling pathway, driving M2 macrophage polarisation, migration and fibrogenic gene expression. targeted inhibition of TREM2 thus represents a promising novel strategy against renal fibrosis.
Jia Wei, Zixia Li, Gengyu Du, Ting Chen, Min Yang, Zhen Yuan, Yidan Zheng, Xiang Yan   +7 more
wiley   +1 more source

A Snake Toxin Derivative for Treatment of Hyponatremia and Polycystic Kidney Diseases. [PDF]

J Am Soc Nephrol
Stanajic-Petrovic G, Keck M, Barbe P, Urman A, Correia E, Isnard P, Duong Van Huyen JP, Chmeis K, Diarra SS, Palea S, Theodoro F, Nguyen AL, Castelli F, Pruvost A, Zhao W, Mendre C, Mouillac B, Bienaimé F, Robin P, Kessler P, Llorens-Cortes C, Servent D, Nozach H, Maillère B, Guo D, Truillet C, Gilles N.   +26 more
europepmc   +1 more source

Recipient Selection and Outcomes After Out‐of‐Sequence Kidney Allocation Since Implementation of Kidney Allocation System 250 (KAS250): A Single‐Center Experience

Clinical Transplantation, Volume 40, Issue 8, August 2026.
ABSTRACT Introduction Allocation out of sequence (AOOS) of kidneys has increased after KAS250 and raised concerns regarding transparency and equitable recipient selection. Less is known about recipient selection and outcomes at individual centers. Methods We performed a single‐center retrospective study of adult deceased donor kidney transplants at the
Sandesh Parajuli, Glen E. Leverson, Didier Mandelbrot, Dixon B. Kaufman   +3 more
wiley   +1 more source

An extracellular vesicle based hypothesis for the genesis of the polycystic kidney diseases. [PDF]

Extracell Vesicle
Hogan MC, Ward CJ.
europepmc   +1 more source

Polycystic kidney disease

Kidney International, 1982
openaire   +2 more sources

Short‐Term Combined Treatment With Tirzepatide and Metformin for Overweight/Obese Chinese Women With Polycystic Ovary Syndrome: A Prospective, Open‐Label, Randomised Controlled Trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 7380-7392, August 2026.
ABSTRACT Aims This study aimed to assess the effects of low‐dose tirzepatide combined with metformin (COM) versus metformin (MET) monotherapy in overweight/obese women with polycystic ovary syndrome (PCOS). Materials and Methods Sixty overweight/obese women with PCOS were randomised to the MET group (1000 mg twice daily [BID]) or the COM group (MET ...
Zhuoran Yang, Yuxin Xu, Hu Du, Wenya Liu, Haiyan Chen, Dongfang Liu, Lili Zhang, Cong Wang   +7 more
wiley   +1 more source

High level of patient satisfaction with incremental haemodialysis: insights from a single‐centre patient‐reported experience study

Internal Medicine Journal, Volume 56, Issue 8, Page 1438-1442, August 2026.
Abstract A single‐centre, anonymous survey study was conducted to investigate patient experience and quality of life (Kidney Disease Quality of Life‐36) in individuals receiving incremental haemodialysis, with all 20 eligible patients participating.
Kavita L. Dilip, Louis L. Huang, Peter F. Mount   +2 more
wiley   +1 more source

Amino acid homeostasis in the kidney: Physiological roles and pathological dysregulation

Physiological Reports, Volume 14, Issue 15, August 2026.
Abstract Amino acids are fundamental to life as protein building blocks and key regulators of metabolism and signaling. The kidney plays a critical, yet underappreciated, role in amino acid homeostasis through three interconnected pillars: selective glomerular filtration, efficient tubular reabsorption, and metabolic processing, which includes de novo ...
Shuo Liu, Caifeng Shi, Yang Zhou, Chunsun Dai   +3 more
wiley   +1 more source