Results 121 to 130 of about 33,975 (227)

A Case of Clear Cell Papillary Renal Cell Tumor: A Rare Entity With an Unusual Presentation

open access: yesClinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Clear cell papillary renal cell Tumor (CCPRCT) is a rare variant of renal cell carcinoma that typically arises in a nonfunctional kidney. We report a case of CCPRCT in a 49‐year‐old Iranian male who presented with a mural nodule within a large cystic mass in his nonfunctional left kidney, and we discuss the relevant diagnostic challenges ...
Mehdi Montazer   +3 more
wiley   +1 more source

Epigenetic Perspectives on Maternal Gut Microbiota's Impact on Embryonic and Fetal Development

open access: yesComprehensive Physiology, Volume 16, Issue 3, June 2026.
This review summarizes how maternal health and nutrition shape gut microbiota via epigenetics to regulate embryonic development. It highlights microbiota‐embryo interactions, disruption by prenatal chemical exposures, and personalized nutrition for disease prevention, offering novel insights and therapeutic targets.
Shoulong Xu   +6 more
wiley   +1 more source

More Than a Question of Correlation: Characterization of the Evidentiary Basis for Biomarker Surrogates Used in European Marketing Authorizations

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1522-1536, June 2026.
Traditionally, clinical outcomes measuring how a patient feels, functions, or survives are preferred endpoints in clinical trials; however, some may take a long time to manifest in slowly developing diseases. Biomarkers, if properly validated, can serve as surrogate endpoints, acting as substitutes for clinical outcomes.
Renske Johanna Grupstra   +4 more
wiley   +1 more source

Tooth Loss and Uncontrolled Diabetes Among Korean Adults With Type 2 Diabetes: Insights From the Korea National Health and Nutrition Examination Survey (KNHANES) 2014–2018

open access: yesClinical and Experimental Dental Research, Volume 12, Issue 3, June 2026.
ABSTRACT Objectives The relationship between tooth loss and glycemic control status in diabetes is inconclusive. Material and Methods Using data from the 2014–2018 Korean National Health and Nutrition Examination Survey (KNHANES), 2146 adults with diabetes aged ≥ 40 years were categorized by number of remaining teeth (0–19, 20–27, and ≥ 28 ...
Eun Sik Lee   +9 more
wiley   +1 more source

Exploring the Nutraceutical Potential of Achillea millefolium L.: Phytochemical Composition, Biological Activities, and Industrial Applications

open access: yesFood Science &Nutrition, Volume 14, Issue 6, June 2026.
Achillea millefolium Linn., commonly known as yarrow, is an extraordinary medicinal plant. A. millefolium has broad therapeutic potential due to its phytochemistry and essential oil composition. It possesses pharmacological properties, including antidiabetic, antioxidant, anti‐inflammatory, liver‐protective, antimicrobial, and gastroprotective effects,
Tooba Majeed   +14 more
wiley   +1 more source

Effects of Total Flavonoids From Rubus chingii Hu on the Hypothalamic–Pituitary–Ovarian Axis and Inflammatory Response in Polycystic Ovary Syndrome Rats

open access: yesFood Science &Nutrition, Volume 14, Issue 6, June 2026.
RHF improves sex hormone secretion imbalance, restores the estrous cycle, inhibits ovarian hyperplasia and pathology, and reduces systemic and local ovarian inflammation in PCOS rats via enhancing HPO axis function and suppressing NLRP3 inflammasome signaling pathway activation.
Mengfan Peng   +7 more
wiley   +1 more source

Application of Artificial Intelligence in the Diagnosis, Prediction, and Management of Metabolic Syndrome: A Systematic Review

open access: yesHealth Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Metabolic syndrome (MetS) is associated with increased risks of cardiovascular disease and type 2 diabetes, with recent global prevalence estimates of approximately 28%–31% in adults. Artificial intelligence (AI) and machine learning offer potential to improve risk stratification beyond conventional statistical methods ...
Aynaz Esmailzadeh   +4 more
wiley   +1 more source

DAMP Laden Extracellular Vesicles From the Airways of Patients With Severe SARS‐CoV‐2 Respiratory Infection Compromise Inflammation and Cellular Metabolism

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
Extracellular vesicles from severe COVID‐19 airways carry depleted miRNAs and elevated DAMPs, reprogramming monocytes toward senescence, impaired metabolism, and predominantly reduced cytokine responses. However, they drive excess IL‐8 production, amplifying neutrophil recruitment and dysfunctional inflammation across the respiratory tract.
April Rees   +14 more
wiley   +1 more source

Counseling patients in the predictive genetics clinic for Huntington's disease: A qualitative analysis of ethnographic observations

open access: yesJournal of Genetic Counseling, Volume 35, Issue 3, June 2026.
Abstract Little research has been conducted on patients' experiences inside the predictive genetics clinic. In this clinic, a person with a familial risk of inheriting a rare disease seeks a test that will provide them with information about their future health.
Shane Doheny   +5 more
wiley   +1 more source

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