Results 131 to 140 of about 2,624,306 (259)

Inspiring Tactics with the Improvement of Mitophagy and Redox Balance for the Development of Innovative Treatment against Polycystic Kidney Disease

Polycystic kidney disease (PKD) is the most common genetic form of chronic kidney disease (CKD), and it involves the development of multiple kidney cysts.
池田 祐香, Suga Naoko, 菅 尚子, Yoshikawa Sayuri, 1000050908168, Ikeda Yuka, Matsuda Satoru, すが なおこ, いけだ ゆか, Nakashima Moeka   +9 more
core   +1 more source

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley   +1 more source

The pathogenesis of polycystic kidney disease.

Histology and histopathology, 1995
Polycystic kidney disease (PKD) is a genetic or acquired disorder characterized by progressive distention of multiple tubular segments and manifested by fluid accumulation, growth of non-neoplastic epithelial cells and remodeling of the extracellular matrix resulting ultimately in some degree of renal functional impairment, with the potential for ...
Carone, F.A., Bacallao, R., Kanwar, Y.S.
openaire   +2 more sources

Use of prostanoid receptors as a therapeutic target for polycystic kidney diseases

Background: Beyond tolvaptan, there are no other therapies for polycystic kidney diseases (PKD), a class of inherited cystic kidney diseases. Many of the PKD-inducing mutations translate into changes in cyclic AMP (cAMP) signaling, which is understood to
Sidhu, Karanbir
core  

FLCN Multi‐Exon Deletion in a Chihuahua With Renal Cysts and Nodular Dermatofibrosis

Animal Genetics, Volume 57, Issue 5, October 2026.
Melvin Schneiter, Julie Selz, Jacky Jonker, Martina Dettwiler, Vidhya Jagannathan, Tosso Leeb, Elisa Maina   +6 more
wiley   +1 more source

Quantitative Susceptibility Mapping of Kidney Stones: An Ex Vivo MRI Phantom Study

Magnetic Resonance in Medicine, Volume 96, Issue 4, Page 1846-1859, October 2026.
ABSTRACT Purpose To visualize and characterize the five most common kidney stone types based on their magnetic susceptibilities in MRI using QSM. Methods Three water‐based agar phantoms were constructed, containing a total of 53 ex vivo kidney stones of varying types and sizes.
Lion H. Mücke, Frederik B. Laun, Ruben de Figueiredo Cardoso, Guillaume Flé, Jennifer Lorenz, Alexander Fichte, Michael Uder, Nadine Bayerl, Jannis Hanspach   +8 more
wiley   +1 more source

Assessment of glycemic susceptibility across multiple urological and reproductive disorders

Diabetology & Metabolic Syndrome
Objective To test the glycemic susceptibility in three urological cancers and eight urological/reproductive diseases using the Mendelian randomization (MR) method.
Xiongfeng Zeng, Zhen Li, Lede Lin, Xin Wei   +3 more
doaj   +1 more source

Autosomal dominant polycystic kidney disease: updated perspectives

, 2019
Anjay Rastogi,1 Khalid Mohammed Ameen,1 Maha Al-Baghdadi,1 Kelly Shaffer,1 Niloofar Nobakht,1 Mohammad Kamgar,1 Edgar V Lerma21Department of Medicine, Division of Nephrology, David Geffen School of Medicine, Los Angeles, CA, USA; 2Department of Medicine,
Kamgar M, Al-Baghdadi M, Shaffer K, Lerma EV, Rastogi A, Nobakht N, Ameen KM   +6 more
core  

The Bile Acid Signaling Axis: Deciphering the Roles of FXR and TGR5 in Hepatic Steatosis, Fibrosis, and Cancer

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Bile acids (BAs) serve not only as emulsifiers for lipid digestion but also as essential signaling molecules, governing various physiological and pathological processes through their interaction with the farnesoid X receptor (FXR) and the takeda G protein‐coupled receptor 5 (TGR5).
Jie Liu, Kui Sun, Hongmei Liu, Meiyang Zhu, Chunmeng Li, Yuqi He, Lin Qin   +6 more
wiley   +1 more source

Diagnostic and therapeutic potential of interleukin-37 in kidney diseases: A mini-review

Український Журнал Нефрології та Діалізу
Interleukin-37 (IL-37) is a newly discovered anti-inflammatory cytokine from the IL-1 family that plays a key role in regulating both innate and adaptive immune responses.
Nadiia Demikhova, Larysa Kuts, Svitlana Bokova, Olga Vlasenko, Eda Merisalu   +4 more
doaj   +1 more source