Results 111 to 120 of about 54,094 (256)
Compartmentalisation in cAMP signalling: A phase separation perspective
British Journal of Pharmacology, EarlyView.Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley +1 more source
Genetic linkage study of family members of a patient with adult polycystic kidney disease [PDF]
, 1999 OBJECTIVE. To study the feasibility of making an early diagnosis of adult polycystic kidney disease by using genetic linkage analysis in Hong Kong. DESIGN. Genetic linkage study. SETTING. University teaching hospital, Hong Kong. PARTICIPANTS.
Chan, DTM +4 more
core
Dynamics of Apolipoprotein J Levels and Metabolic Parameters Following Bariatric Surgery
Clinical Endocrinology, EarlyView.ABSTRACT Objective Bariatric surgery has emerged as a potent intervention for ameliorating insulin resistance and its associated comorbidities in obese patients. Apolipoprotein J (ApoJ) and adiponectin are closely associated with insulin resistance and sensitivity, respectively.
Kellen Cristina da Cruz Rodrigues +7 more
wiley +1 more source
Retroperitoneal extramedullary hematopoietic pseudotumor in ataxia-telangiectasia. [PDF]
, 2018 Ataxia-telangiectasia confers a significant increase in the development of several cancer types, most commonly leukemia and lymphoma. However, as the natural history for these patients is evolving and their lifespan is increasing, there is the potential ...
Bateni, Cyrus P +5 more
core
Cell Proliferation, EarlyView.Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) promotes obstructive nephropathy progression by activating the β‐catenin signalling pathway, driving M2 macrophage polarisation, migration and fibrogenic gene expression. targeted inhibition of TREM2 thus represents a promising novel strategy against renal fibrosis.
Jia Wei +7 more
wiley +1 more source
Renal cell carcinoma in a cat with polycystic kidney disease undergoing renal transplantation
Journal of Feline Medicine and Surgery Open Reports, 2018 Case summary A 10-year-old spayed female American Shorthair cat underwent renal transplantation due to worsening chronic kidney disease secondary to polycystic kidney disease.
Daniel J Adams +2 more
doaj +1 more source
Stem cells and fluid flow drive cyst formation in an invertebrate excretory organ.
, 2015 Cystic kidney diseases (CKDs) affect millions of people worldwide. The defining pathological features are fluid-filled cysts developing from nephric tubules due to defective flow sensing, cell proliferation and differentiation.
Alexander, R. +6 more
core +1 more source
The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation
The FEBS Journal, EarlyView.The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak +7 more
wiley +1 more source
Pregnancy associated plasma protein-A: a promising biomarker in kidney diseases
Türk Biyokimya DergisiKidney diseases are a worldwide public health problem with more than 850 million patients all over the world. Therefore, early diagnosis is essential for effective treatment of any renal disease. Most biomarkers have the potential to be used in diagnosis,
Ceylaner Betül +3 more
doaj +1 more source