Results 91 to 100 of about 33,975 (227)

Glucagon‐Like Peptide‐1 Receptor Agonists and Incident Major Adverse Liver Outcomes in People With Type 2 Diabetes and Metabolic Dysfunction‐Associated Steatotic Liver Disease

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Treatment options for metabolic dysfunction‐associated steatotic liver disease (MASLD) are limited. While glucagon‐like peptide‐1 receptor agonists (GLP‐1 RA) and sodium‐glucose cotransporter‐2 (SGLT‐2) inhibitors improve cardiovascular outcomes, comparative effectiveness on liver‐related outcomes remains unclear.
Gregor A. Maier, Ramon A. Hofmann, Michael Roden, Wolfgang Rathmann, Oliver Kuss   +4 more
wiley   +1 more source

Pregnancy associated plasma protein-A: a promising biomarker in kidney diseases

Türk Biyokimya Dergisi
Kidney diseases are a worldwide public health problem with more than 850 million patients all over the world. Therefore, early diagnosis is essential for effective treatment of any renal disease. Most biomarkers have the potential to be used in diagnosis,
Ceylaner Betül, Savaş İrem Nur, Meşe Meral, Bicik Bahçebaşı Zerrin   +3 more
doaj   +1 more source

Prevalence of Obesity and Related Conditions and GLP‐1 Use in Medicare Fee‐for‐Service Beneficiaries

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims This study estimated the number and percentage of Medicare fee‐for‐service (FFS) beneficiaries who use GLP‐1 RAs, are currently eligible or could become eligible if ongoing‐trial indications receive approval and coverage. Materials and Methods This retrospective cohort study used Medicare enrolment and claims data, representing 100% of ...
Sonia Kim, Andrea Barthel, Marlene Smurzynski, Joanna MacEwan   +3 more
wiley   +1 more source

Complications of polycystic kidney disease

Kidney International, 1997
A 33-year-old white man first presented to the Royal Infirmary Stirling, Scotland, 24 years ago with a history of recent-onset hematuria. Intravenous urography at that time showed a filling defect in the right kidney; a subsequent aortogram demonstrated a single simple cyst in the right kidney.
openaire   +2 more sources

The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation

The FEBS Journal, EarlyView.
The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak, In‐Ja L. Byeon, Ryan Ponticelli, Mary E. Lucas, Lariah Thompson, Christopher DeHaven, Gary Thomas, Angela M. Gronenborn   +7 more
wiley   +1 more source

Healthcare costs of managing MAFLD are mostly driven by hospitalisation and advanced fibrosis: cost‐analysis from a tertiary‐care, multi‐disciplinary MAFLD clinic

Internal Medicine Journal, EarlyView.
Abstract Background and Aims Patients with metabolic (dysfunction)‐associated fatty liver disease (MAFLD) are frequently multimorbid, putting upward pressure on healthcare costs compared to other liver diseases. As Australian data are limited on expenditures in managing MAFLD, we evaluated hospital‐related costs and predictors of costs in patients ...
Natalie Ngu, Karl Vaz, Tobie Abrahams, Carmela Cosentino, John Lubel, Ammar Majeed, Stuart K Roberts, William Kemp   +7 more
wiley   +1 more source

Growth‐regulating proteins differ between British seawater fish species, shedding light on their ecological adaptations

Journal of Fish Biology, EarlyView.
Abstract Wnt proteins are a family of molecules that help control how cells grow, develop and communicate – processes that are fundamental to the development and health of all animals. Although Wnt pathways have been studied extensively in model species, very little is known about how they operate in marine fish.
Angeliki Maravelia, Soniya Malik, Clare Murcott, Ioannis Batzakas, Paraskevi Goggolidou   +4 more
wiley   +1 more source

Outcomes for Frail Dialysis Patients Not Referred for Transplantation: A Cohort Study

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Frailty is highly prevalent in kidney failure, but it is unclear whether frailty impacts health outcomes for those initiating dialysis who are not referred for transplantation. Our objective was to determine if frailty is associated with death or development of a permanent contraindication to transplantation among eligible non ...
Joshua Goodwin, Jordan Thorne, Amanda Vinson, David Clark, Bryce Kiberd, Micheal Sun, Karthik Tennankore   +6 more
wiley   +1 more source

ARC in Critical Ill OLT Recipients: True Prevalence, Risk Factors, and Impact on Early Aggressive PK/PD Target Non‐Attainment of CI Beta‐Lactam Therapy for Posttransplant Gram‐Negative Infections

Transplant Infectious Disease, EarlyView.
Augmented renal clearance (ARC) represents a quite prevalent condition among critical orthotopic liver transplant recipients (23.2%). ARC is associated with different demographics and clinical features and significantly affects the attainment of aggressive beta‐lactams pharmacokinetic/pharmacodynamic targets despite the administration of standard ...
Milo Gatti, Riccardo De Paola, Matteo Rinaldi, Cristiana Laici, Antonio Siniscalchi, Pierluigi Viale, Federico Pea   +6 more
wiley   +1 more source

Bridging the Gap Between General and Transplant Infectious Disease Practice

Transplant Infectious Disease, EarlyView.
ABSTRACT The population of iatrogenic immunocompromised individuals is steadily rising as we continue to improve in our ability to manage diseases, including cancer, autoimmune disease, and end‐organ dysfunction, with increasing access to novel agents and transplantation.
Jeremey Walker, Emily Eichenberger, Steven Pergam, Maricar Malinis, Andrea J. Zimmer   +4 more
wiley   +1 more source