Results 71 to 80 of about 34,123 (218)

The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation

The FEBS Journal, EarlyView.
The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak, In‐Ja L. Byeon, Ryan Ponticelli, Mary E. Lucas, Lariah Thompson, Christopher DeHaven, Gary Thomas, Angela M. Gronenborn   +7 more
wiley   +1 more source

Bioimpedance and Symptom Guided Fluid Management in Hemodialysis: A Multicenter Pre–Post Implementation Study

Hemodialysis International, EarlyView.
ABSTRACT Background Optimizing volume status is central to hemodialysis care and may influence patient‐reported outcome measures as recovery time. We evaluated the implementation of a structured decision aid (Recova) integrating symptom assessment with bioimpedance spectroscopy in routine hemodialysis practice.
Maaike Nielen, Maria K. Svensson, Hans Furuland, Ursa Bonnevier, Ainhoa Indurain, Annica Sedin, Michael Eklund, Jenny Stenberg   +7 more
wiley   +1 more source

Montelukast Versus Gabapentin for Uremic Pruritus in Twice‐Weekly Hemodialysis Patients: A 52‐Week Prospective Non‐Randomized Open‐Label Comparative Study

Hemodialysis International, EarlyView.
ABSTRACT Background Uremic pruritus (UP) remains a common and distressing complication in patients with end‐stage renal disease (ESRD) receiving maintenance hemodialysis. The burden is particularly pronounced in low‐ and middle‐income countries where twice‐weekly hemodialysis is frequently practiced because of resource limitations. Gabapentin is widely
Bilal Mohsin, Muhammad Ahmad, Irfan Rasool, Nouf Alotaibi, Wahaj Mirajullah, Imran Khan, Sara Faisal, Khalid Abdulrazek, Aziz Mengal, Saima Faisal   +9 more
wiley   +1 more source

PKR activation-induced mitochondrial dysfunction in HIV-transgenic mice with nephropathy

eLife
HIV disease remains prevalent in the USA and chronic kidney disease remains a major cause of morbidity in HIV-1-positive patients. Host double-stranded RNA (dsRNA)-activated protein kinase (PKR) is a sensor for viral dsRNA, including HIV-1.
Teruhiko Yoshida, Khun Zaw Latt, Avi Z Rosenberg, Briana A Santo, Komuraiah Myakala, Yu Ishimoto, Yongmei Zhao, Shashi Shrivastav, Bryce A Jones, Xiaoping Yang, Xiaoxin X Wang, Vincent M Tutino, Pinaki Sarder, Moshe Levi, Koji Okamoto, Cheryl A Winkler, Jeffrey B Kopp   +16 more
doaj   +1 more source

Axial Spondyloarthritis and Autosomal Dominant Polycystic Kidney Disease in Two Siblings: A Rare Cooccurrence

Case Reports in Rheumatology, 2018
Autosomal dominant polycystic kidney disease (ADPKD) is the most frequently occurring hereditary kidney disease, and axial spondyloarthritis (SpA) is one of the most frequently occurring rheumatic diseases.
Ozan Volkan Yurdakul, Abdulkerim Furkan Tamer, Okan Küçükakkaş, Aylin Rezvani   +3 more
doaj   +1 more source

UltRaSoUnd‐guided evaLuAtion of metabolic health in a cohort of midlife women with HIV: The URSULA study

HIV Medicine, EarlyView.
Abstract Objectives We aimed to determine the prevalence of metabolic disorders, liver steatosis and metabolic dysfunction‐associated steatotic liver disease (MASLD) in a cohort of middle‐aged women with HIV (WoWH) and to explore associations between liver steatosis, visceral fat depots and carotid atherosclerosis.
Mariacristina Poliseno, Davide Capruzzi, Antonio Cianciaruso, Nicola Colavito, Felicia Dalitto, Vincenzo Giliberti, Vittoria Lobalsamo, Giuliana Metrangolo, Marica Noviello, Alessandra Vigna, Maurizio Zarcone, Francesco Di Gennaro, Vincenzo Ostilio Palmieri, Annalisa Saracino   +13 more
wiley   +1 more source

Critical role of vaccination in preventing severe coronavirus disease 2019: perspectives from clinical outcomes in an Australian kidney transplant recipient cohort

Internal Medicine Journal, EarlyView.
Abstract Background Kidney transplant recipients (KTRs) disproportionately experience severe COVID‐19 infections. We previously identified concern regarding vaccine‐induced rejection as a barrier to vaccine uptake. Aim This study assesses COVID‐19 vaccine uptake, infection outcomes and allograft rejection in KTRs during the delta and omicron waves (BA ...
Dhakshayini Tharmaraj, Paayal Naidu, Mohana Baptista, Sarah McBride, Rhonda Stuart, Claire Dendle, Kevan R. Polkinghorne, William R. Mulley   +7 more
wiley   +1 more source

Comprehensive strategy improves the genetic diagnosis of different polycystic kidney diseases. [PDF]

J Cell Mol Med, 2021
Hu HY, Zhang J, Qiu W, Liang C, Li CX, Wei TY, Feng ZK, Guo Q, Yang K, Liu ZG.   +9 more
europepmc   +1 more source

Soluble Immune Checkpoints and Anti‐HLA Antibodies in Kidney Transplant Recipients: Associations With Kidney Function

Immunology, EarlyView.
Soluble immune checkpoints, anti‐HLA panel‐reactive antibodies, and kidney function parameters were evaluated to investigate their associations with early graft function. Pre‐transplant patients showed higher levels of sCD25, sPD‐L1, sTIM‐3, Gal‐9, sCD27, and sPD‐L2 than healthy controls, while post‐transplant temporal changes were observed in sCD25 ...
Cemil Pehlivanoğlu, Fırat Demircan, Başak Aru, Süheyla Apaydın, Abdullah Demir, Rabia Tığlı, Gürkan Tellioğlu, Ali Osman Gürol, Gülderen Yanıkkaya Demirel   +8 more
wiley   +1 more source

Global Burden of Key Components of Cardiovascular–Kidney–Metabolic Syndrome Among Women of Reproductive Age, 1990–2021

Journal of Evidence-Based Medicine, EarlyView.
ABSTRACT Objective Cardiovascular–kidney–metabolic (CKM) syndrome links metabolic, kidney, and cardiovascular disorders, but its burden among women of reproductive age (WRA) remains poorly understood. We quantified the global burden and trends of key CKM‐related conditions and high body mass index (BMI)‐attributable burden among WRA.
Cuiping Jiang, Jieyuzhen Qiu, Chuanli Wei, Enhui Zhou, Huaming Zhu, Weijun Huang, Tianjiao Zhou, Ji Hu   +7 more
wiley   +1 more source