Results 61 to 70 of about 2,624,306 (259)

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Polycystic kidney syndrome in New Zealand White rabbits resembling human polycystic kidney disease [PDF]

, 2004
Polycystic kidney syndrome in New Zealand White rabbits resembling human polycystic kidney disease.BackgroundCystic kidney diseases are an important cause of morbidity and mortality in humans.
Marini, Robert P., Fox, James G., Rogers, Arlin B., Maurer, Kirk J.   +3 more
core   +1 more source

Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives

JSFA reports, EarlyView.
Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz, Muhammad Tauseef Sultan, Muhammad Israr, Waqas Ahmad Khan, Fahad Tanveer, Muzzamal Hussain, Muhammad Imran, Ahmed Mujtaba, Anjuman Gul Memon, Muhammad Atif, Entessar Al Jbawi   +10 more
wiley   +1 more source

CALCIUM HOMEOSTASIS AND POLYCYSTIN-2 EXPRESSION IN T-LYMPHOBLASTS OF PKD SUBJECTS [PDF]

, 2009
Mutations of polycystin-1 (PC1) and polycystin-2 (PC2), coded by PKD1 and PKD2 genes, account for approximately 85 and 15% of Autosomal Dominant Polycystic Kidney Disease (ADPKD) cases, a common and important inherited kidney disorder.
Durante, Chiara
core  

Patterns of Kidney Function Decline in Autosomal Dominant Polycystic Kidney Disease: A Post Hoc Analysis From the HALT-PKD Trials

, 2018
Background: Previous clinical studies of autosomal dominant polycystic kidney disease (ADPKD) reported that loss of kidney function usually follows a steep and relentless course.
Rahbari-Oskoui, Frederic F., Theodore Steinman, Jesse Wei, Schrier, Robert, Torres, Vicente E., Czarnecki, Peter, Steinman, Theodore I., Torres, Vicente, Masoumi, Amirali, Perrone, Ronald D., Rocco, Michael, Dana C. Miskulin, Yu, Alan, William E. Braun, James E. Bost, Vicente Torres, Miskulin, Dana, Hogan, Marie C., Wetzel, Louis, Godela M. Brosnahan, Ronald Perrone, Greene, Tom, Abebe, Kaleab Z., James Glockner, Briggs, Josephine, Erick Remer, Kaleab Z. Abebe, Shayman, James, Patel, Nayana, Bost, James E., Michael F. Flessner, Mittal, Pardeep, Meyers, Catherine M., Berenice Gitomer, Nayana Patel, Harris, Peter C., Kyongtae T. Bae, Franz Winklhofer, Saul Nurko, Connie Wang, Bae, Kyongtae T., Josephine Briggs, Peter C. Harris, William Henrich, Henrich, William, Wendler, David, Marie C. Hogan, Glockner, James, Vicente E. Torres, Grantham, Jared J., Nurko, Saul, King, Bernard, Dana Miskulin, Chapman, Arlene B., Miskulin, Dana C., Kelleher, Cass, Peter Czarnecki, Miller, J. Philip, Kyongtae Bae, Moore, Charity G., Robert W. Schrier, Peter McCullough, Jared Grantham, Frederic F. Rahbari-Oskoui, Theodore I. Steinman, Amirali Masoumi, McCullough, Peter, Cass Kelleher, Winklhofer, Franz, Frederic Rahbari-Oskoui, Tom Greene, Martin, Diego, Leonard, Mary, Ivan Pedrosa, Ronald D. Perrone, Godela Brosnahan, Diego Martin, Star, Robert, William Braun, Robert Star, Moe, Sharon, Charity G. Moore, Mary Leonard, Gitomer, Berenice, El-Zoghby, Ziad, Wang, Connie, Chapman, Arlene, Bernard King, James Shayman, Arlene Chapman, Peter Harris, Halin, Neil, Brosnahan, Godela M., Thompson, Paul A., Jared J. Grantham, J. Philip Miller, Schrier, Robert W., Michael Flessner, Flessner, Michael F., Paul A. Thompson, Robert Schrier, Bae, Kyongtae, Braun, William E., Alan Yu, Louis Wetzel, Catherine M. Meyers, Neil Halin, Ziad El-Zoghby, Remer, Erick, Sharon Moe, David Wendler, Pedrosa, Ivan, Arlene B. Chapman, Pardeep Mittal, Wei, Jesse, Michael Rocco   +115 more
core   +1 more source

Gymnema sylvestre: Bioactive constituents, health benefits, and emerging applications in nutraceuticals and functional foods

JSFA reports, EarlyView.
Abstract Gymnema sylvestre (Retz.) R.Br. ex‐Schult., commonly known as “gurmar” or “sugar destroyer,” belongs to the Apocynaceae family and is traditionally used in Ayurveda for diabetes management. This review synthesizes ethnomedicinal evidence with contemporary pharmacological studies, to evaluate the therapeutic properties and mechanistic actions ...
Faiza Saeed, Muhammad Tauseef Sultan, Hassan Raza, Ahmad Mujtaba Noman, Nimra Haroon, Entessar Mohammad Al Jbawi   +5 more
wiley   +1 more source

Engineered Kidney Tubules for Modeling Patient-Specific Diseases and Drug Discovery

EBioMedicine, 2018
The lack of engineering systems able to faithfully reproduce complex kidney structures in vitro has made it difficult to efficiently model kidney diseases and development.
Valentina Benedetti, Valerio Brizi, Patrizia Guida, Susanna Tomasoni, Osele Ciampi, Elena Angeli, Ugo Valbusa, Ariela Benigni, Giuseppe Remuzzi, Christodoulos Xinaris   +9 more
doaj   +1 more source

SURMOUNT‐REAL UK: A Pragmatic Randomized Clinical Trial to Assess the Effectiveness of Tirzepatide in Adults With Obesity

Obesity, EarlyView.
ABSTRACT Objective SURMOUNT‐REAL UK will evaluate the effectiveness of tirzepatide when offered in addition to standard‐of‐care (SoC) in adults with Class I obesity (BMI ≥ 30 and ≤ 34.9 kg/m2) and without diabetes in a UK primary care setting. Methods A 5‐year, phase 4, multicenter, open‐label, pragmatic randomized clinical trial is enabled through ...
Martin K. Rutter, Julie Mount, J. Martin Gibson, Joanne Webb, Cheryl Marler, Catherine Reed, Mugdha Gore, Wenyu Ye, Elisa Gomez Valderas, John Wilding, Naveed Sattar, Melanie J. Davies, Kamlesh Khunti, Richard Haynes, Rachel L. Batterham   +14 more
wiley   +1 more source

Polycystic liver disease with huge infected cyst displacing the pancreas, inferior vena cava and right kidney

Saudi Journal of Medicine and Medical Sciences, 2016
Multiple liver cysts can be an isolated disease (isolated polycystic liver disease [PLD]) or they can be part of multi-organ involvement in other diseases, such as adult autosomal dominant polycystic disease (APD), which is the most frequently inherited ...
Adil H Al-Harthi, Patan M Khan, Marwan Al Marwani   +2 more
doaj   +1 more source