Results 101 to 110 of about 2,624,306 (259)

Rationale and design of the TEMPO (Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and its Outcomes) 3-4 Study.

, 2011
Current management of autosomal dominant polycystic kidney disease (ADPKD) is focused on treating disease complications, not on slowing cyst development or preventing progression to kidney failure.
Grantham, Jared J., Vicente E. Torres, Torres, Vicente E., Meijer, Esther, Eiji Higashihara, Kyongtae T. Bae, Olivier Devuyst, Ronald D. Perrone, Chapman, Arlene B., Krasa, Holly B., Higashihara, Eiji, John J. Ouyang, Perrone, Ronald D., Esther Meijer, Ouyang, John J., Bae, Kyongtae T., Jared J. Grantham, Arlene B. Chapman, Devuyst, Olivier, Ron T. Gansevoort, Gansevoort, Ron T., Czerwiec, Frank S., Holly B. Krasa, Frank S. Czerwiec   +23 more
core   +1 more source

Should a paediatrician perform abdominal ultrasonography inchildren of parents with polycystic kidney disease? [PDF]

, 2016
Autosomal dominant polycystic kidney disease produces symptoms mainly in adulthood. Renal cysts and/or elevated blood pressure can be the first signs of the disease in children.
Krzysztof Wróblewski, Marcin Tkaczyk, Tkaczyk, Marcin, Afshari, Susan, Katarzyna Młudzik, Wróblewski, Krzysztof, Młudzik, Katarzyna, Piotr Grzelak, Grzelak, Piotr, Susan Afshari   +9 more
core   +1 more source

Attrition and Delays in Kidney Transplant Evaluation Among People Living With HIV and End‐Stage Renal Disease

Transplant Infectious Disease, EarlyView.
Among people living with HIV and end‐stage renal disease evaluated for kidney transplantation, most progressed successfully through evaluation and were waitlisted once engaged in the process. However, substantial delays occurred across the transplant continuum, with attrition driven primarily by incomplete testing and structural barriers rather than ...
Kyle M. Crawford, Jillian Catalano, Dhriti Shah, Scott Curry, Alexandra G. Mills, Yosra Alkabab, Drew Charles, Courtney E. Harris, Ruth O. Adekunle   +8 more
wiley   +1 more source

PKR activation-induced mitochondrial dysfunction in HIV-transgenic mice with nephropathy

eLife
HIV disease remains prevalent in the USA and chronic kidney disease remains a major cause of morbidity in HIV-1-positive patients. Host double-stranded RNA (dsRNA)-activated protein kinase (PKR) is a sensor for viral dsRNA, including HIV-1.
Teruhiko Yoshida, Khun Zaw Latt, Avi Z Rosenberg, Briana A Santo, Komuraiah Myakala, Yu Ishimoto, Yongmei Zhao, Shashi Shrivastav, Bryce A Jones, Xiaoping Yang, Xiaoxin X Wang, Vincent M Tutino, Pinaki Sarder, Moshe Levi, Koji Okamoto, Cheryl A Winkler, Jeffrey B Kopp   +16 more
doaj   +1 more source

Comprehensive strategy improves the genetic diagnosis of different polycystic kidney diseases. [PDF]

J Cell Mol Med, 2021
Hu HY, Zhang J, Qiu W, Liang C, Li CX, Wei TY, Feng ZK, Guo Q, Yang K, Liu ZG.   +9 more
europepmc   +1 more source

Maternal protein restriction programs the ageing kidney: Proteomic signatures of early‐life origin renal and metabolic dysfunction

The Journal of Physiology, EarlyView.
Abstract figure legend Maternal protein restriction (MPR) induced persistent renal histopathological alterations accompanied by elevated serum creatinine levels. Nephron‐segment proteomic analysis revealed region‐specific molecular dysregulation affecting Bowman's capsule (PARK7, oxidative stress sensor; MSN, cytoskeletal organization), the proximal ...
Marina Pereira Pires, Matheus Naia Fioretto, Marcel Rodrigues Ferreira, Isabelle Tenori Ribeiro, Luísa Annibal Barata, Flávia Alessandra Maciel, Lucas Sobrinho Lemos, Renato Mattos, Luiz Marcos Frediane Portela, Patrick Vieira de Souza, Luisa Correia Gomes, Gustavo Monezzi Cordeiro, Wellerson Rodrigo Scarano, Patrícia Aline Boer, Jose Antonio Rocha Gontijo, Luis Antonio Justulin   +15 more
wiley   +1 more source

Long-term trajectory of kidney function in autosomal-dominant polycystic kidney disease

, 2019
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by cyst and kidney growth, which is hypothesized to cause loss of functioning renal mass and eventually end-stage kidney disease.
Rahbari-Oskoui, Frederic F., Harris, Peter C., Torres, Vicente E., Frederic F. Rahbari-Oskoui, William M. Bennett, Cook, Larry T., Chengli Shen, Jared J. Grantham, Alan S.L. Yu, Peter C. Harris, Tiange Shi, Douglas P. Landsittel, Bae, Kyongtae Ty, Vicente E. Torres, Yu, Alan S.L., Grantham, Jared J., Mrug, Michal, Michal Mrug, Bennett, William M., Kyongtae Ty Bae, Chapman, Arlene B., Landsittel, Douglas P., Shen, Chengli, Arlene B. Chapman, Shi, Tiange, Larry T. Cook   +25 more
core   +1 more source

Gene‐Guided Therapy in Type 2 Diabetes Mellitus: An Integrative Review of the Pharmacogenetics of Metformin and Sodium‐Glucose Cotransporter‐2 Inhibitors

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 6, November 2026.
Genetic variation influences the pharmacological response to metformin and SGLT2 inhibitors in patients with type 2 diabetes mellitus. Pharmacogenetic biomarkers affecting drug transport, metabolism and target activity contribute to inter‐individual differences in treatment efficacy and adverse effects, supporting the implementation of personalized ...
Imran Hossain, Mahnoor Haidar, Mahfuj Ahmed Ratul, Jannatul Ferdous Sumona, Sraboni Shabnaz, Abul Fojal Nokib, Fatema‐Tuz‐Zohora   +6 more
wiley   +1 more source

Complications of polycystic kidney disease

Kidney International, 1997
A 33-year-old white man first presented to the Royal Infirmary Stirling, Scotland, 24 years ago with a history of recent-onset hematuria. Intravenous urography at that time showed a filling defect in the right kidney; a subsequent aortogram demonstrated a single simple cyst in the right kidney.
openaire   +2 more sources

Polycystic kidney disease: inheritance, pathophysiology, prognosis, and treatment

, 2010
Christian R Halvorson1, Matthew S Bremmer1, Stephen C Jacobs11Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USAAbstract: Both autosomal dominant and recessive polycystic kidney disease are conditions with severe ...
Stephen C Jacobs, Matthew S Bremmer, Christian R Halvorson   +2 more
core