Results 151 to 160 of about 2,624,306 (259)
Recent Advances in Molecular Mechanisms Underlying Kidney Diseases
Kidney diseases remain a major public health concern associated with increasing morbidity and the mortality of millions of people globally. Recently, the prevalence of kidney diseases has increased significantly.
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Association of Three HIF‐1α Genotypes With Susceptibility and Severity of Chronic Kidney Disease
Clinical and Translational Science, Volume 19, Issue 10, October 2026.ABSTRACT Hypoxic signaling is a critical factor in the pathogenesis of Chronic Kidney Disease (CKD). Hypoxia‐Inducible Factor 1 (HIF‐1) is a transcription factor that is highly expressed in the kidney and is associated with renal tubular hypoxic adaptation. Variation in the HIF‐1α subunit gene has been associated with renal pathologies.
Hanifa Aktar +3 more
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The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation
The FEBS Journal, Volume 293, Issue 19, Page 5717-5734, October 2026.The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak +7 more
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HIV Medicine, Volume 27, Issue 10, Page 1650-1662, October 2026.Abstract Objectives We aimed to determine the prevalence of metabolic disorders, liver steatosis and metabolic dysfunction‐associated steatotic liver disease (MASLD) in a cohort of middle‐aged women with HIV (WoWH) and to explore associations between liver steatosis, visceral fat depots and carotid atherosclerosis.
Mariacristina Poliseno +13 more
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Immunology, Volume 179, Issue 2, Page 269-286, October 2026.Soluble immune checkpoints, anti‐HLA panel‐reactive antibodies, and kidney function parameters were evaluated to investigate their associations with early graft function. Pre‐transplant patients showed higher levels of sCD25, sPD‐L1, sTIM‐3, Gal‐9, sCD27, and sPD‐L2 than healthy controls, while post‐transplant temporal changes were observed in sCD25 ...
Cemil Pehlivanoğlu +8 more
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Chinese clinical practice guide for autosomal dominant polycystic kidney disease
, 2019 常染色体显性多囊肾病(autosomal dominant polycystic kidney disease, ADPKD)是最常见的遗传性肾病,患病率为1/400～1/1000[1]。ADPKD主要致病基因有两个,PKD1和PKD2,其突变导致疾病分别约占发病人群的85%和15%[2-3]。该病为常染色体显性遗传病,子代发病机率为50%。患者多在成年后出现双侧肾脏囊肿,随年龄增长,逐渐损害肾脏结构和功能[4 ...
Expert Committee on Clinical Practice Guidelines for Autosomal Dominant Polycystic Kidney Disease
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Journal of Evaluation in Clinical Practice, Volume 32, Issue 7, October 2026.ABSTRACT Rationale Clinical Decision Support Systems (CDSS) are increasingly used to enhance medical decision‐making, including nutrition support. Objective This study aimed to narratively review CDSS tools for enteral nutrition (EN) and to preliminarily evaluate a locally developed internal‐use CDSS designed to calculate patients' nutritional ...
Panos Papandreou +3 more
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Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.Abstract The hypothalamic–pituitary–gonadal (HPG) axis coordinates reproductive function and incorporates gonadal sex steroid feedback to regulate gonadotropin secretion in a homeostatic manner. In females, ovarian estrogens and progestins act as the primary negative feedback signals to suppress luteinizing hormone (LH) release, whereas in males ...
Lillian Rose, Alexander S. Kauffman
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Age- and height-adjusted total kidney volume growth rate in autosomal dominant polycystic kidney diseases. [PDF]
Clin Exp Nephrol, 2019 Higashihara E +9 more
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