Results 61 to 70 of about 36,402 (277)

PKR activation-induced mitochondrial dysfunction in HIV-transgenic mice with nephropathy

eLife
HIV disease remains prevalent in the USA and chronic kidney disease remains a major cause of morbidity in HIV-1-positive patients. Host double-stranded RNA (dsRNA)-activated protein kinase (PKR) is a sensor for viral dsRNA, including HIV-1.
Teruhiko Yoshida, Khun Zaw Latt, Avi Z Rosenberg, Briana A Santo, Komuraiah Myakala, Yu Ishimoto, Yongmei Zhao, Shashi Shrivastav, Bryce A Jones, Xiaoping Yang, Xiaoxin X Wang, Vincent M Tutino, Pinaki Sarder, Moshe Levi, Koji Okamoto, Cheryl A Winkler, Jeffrey B Kopp   +16 more
doaj   +1 more source

Oral MIB‐626 (β Nicotinamide Mononucleotide) Safely Raises Blood Nicotinamide Adenine Dinucleotide Levels in Hospitalized Patients With COVID‐19 and Acute Kidney Injury: A Randomized Controlled Trial

FASEB BioAdvances, EarlyView.
This randomized, placebo‐controlled trial assessed the effects of NAD augmentation by administration of oral β Nicotinamide Mononucleotide (β NMN) 1.0 g twice daily or placebo for 14 days in adult patients hospitalized with COVID‐19 and acute kidney injury on blood NAD, plasma levels of NAD metabolites, biomarkers of acute kidney injury, inflammation ...
Karol M. Pencina, David E. Leaf, Rodrigo J. Valderrabano, Sushrut S. Waikar, Tapan S. Mehta, Yili Valentine Shang, Nancy K. Latham, Tejossy John, Elena Volpi, Dahlene Fusco, Yusnie Memish‐Beleva, Shobana Krishnamurthy, Siva Lavu, Salma Karmi, David J. Livingston, Shalender Bhasin   +15 more
wiley   +1 more source

Polycystic Diseases in Visceral Organs

Obstetrics and Gynecology International, 2011
Primary cilia are nonmotile, microtubule-based, antenna-like organelles projecting from the apical surface of most mammalian cells. Elegant studies have established the importance of ciliary structure and function in signal transduction and the sensory ...
Shakila Abdul-Majeed, Surya M. Nauli
doaj   +1 more source

Impact of barometric pressure on blood pressure during dialysis: Introducing intradialytic time‐averaged cumulative systolic blood pressure (TACsBP‐inD) as a new metric

Therapeutic Apheresis and Dialysis, Volume 29, Issue 3, Page 525-534, June 2025.
Abstract Background Blood pressure is a crucial risk factor for hemodialysis patients, but the specific impact of weather factors, particularly barometric pressure, on blood pressure remains unclear. This study aims to examine the relationship between barometric pressure and blood pressure in hemodialysis patients. Methods We conducted a single‐center,
Kosaku Iwatsubo, Shouichi Fujimoto, Michikazu Nakai   +2 more
wiley   +1 more source

Polycystic Kidney Disease

, 2015
Polycystic kidney disease (PKD) is characterized by the presence of fluid-filled cysts in the kidneys. It is the fourth most common cause of chronic renal insufficiency or end-stage kidney disease. This book focuses on the basic and clinical aspects of the burgeoning PKD research under three sections.
Gregory G. Germino, Lisa M. Guay-Woodford   +1 more
  +6 more sources

Index cases of intracranial aneurysms in autosomal dominant polycystic kidney disease: longitudinal experience from a single renal transplantation centre

ANZ Journal of Surgery, EarlyView.
Abstract Background The prevalence of intracranial aneurysms (ICAs) is higher in patients with autosomal dominant polycystic kidney disease (ADPKD) than in the general population. This extrarenal manifestation carries significant mortality and morbidity risks.
Joel Ern Zher Chan, Kate S. Olakkengil, Shantanu Bhattacharjya, Santosh Antony Olakkengil   +3 more
wiley   +1 more source

CRISPR-Cas9 system in autosomal dominant polycystic kidney disease: a comprehensive review [PDF]

Childhood Kidney Diseases
Genetic kidney diseases are caused by mutations in specific genes that significantly affect kidney development and function. Although the underlying pathogenic genes of many kidney diseases have been identified, an understanding of their mechanisms and ...
Seungyeon Kang, Se Jin Park, Min Ho Lee, Andreas Kronbichler, Jae Il Shin   +4 more
doaj   +1 more source

Dickkopf-3: Current Knowledge in Kidney Diseases

Frontiers in Physiology, 2020
Dickkopf-related protein 3 (DKK3) is a secreted glycoprotein that has been implicated in the pathogenesis of a variety of diseases. Recent evidence suggests that urinary DKK3 may serve as a potential biomarker for monitoring kidney disease progression ...
Xiangdong Fang, Jing Hu, Yanxia Chen, Wen Shen, Ben Ke   +4 more
doaj   +1 more source

Childhood Polycystic Kidney Disease

, 2015
Published
Cynthia Pan, Ellis D. Avner, William E. Sweeney, Ameya Patil   +3 more
openaire   +3 more sources

Autosomal Dominant Polycystic Kidney Disease Patients Requiring Nephrectomy: Characteristics and Surgical Considerations

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background Nephrectomies are major surgeries often required in ADPKD for symptom control, removal of septic/malignant foci, and to create space for renal transplantation. Whether ADPKD patients should proceed with nephrectomy/ies should be guided by patient characteristics, technical considerations and anticipated risks and benefits. Methods A
Joel Ern Zher Chan, Kate S. Olakkengil, Shantanu Bhattacharjya, Santosh Antony Olakkengil   +3 more
wiley   +1 more source