Results 81 to 90 of about 24,424 (206)

Elevated Hemoglobin Levels and Risk of ST‐Segment Elevation Myocardial Infarction in High‐Altitude Acute Coronary Syndrome: A Retrospective Analysis

Catheterization and Cardiovascular Interventions, Volume 107, Issue 4, Page 934-943, March 1, 2026.
ABSTRACT Background High‐altitude populations typically exhibit elevated hemoglobin (Hb) levels due to chronic hypoxic exposure; however, the impact of this elevation on the risk of ST‐segment elevation myocardial infarction (STEMI) remains unclear. Existing evidence is primarily derived from low‐altitude populations and cannot be directly extrapolated
Jing Li, Lin‐Feng Liu, Gusang Lamu, Yang Jin, Gesang Gawa, Zhen‐Long Chang, Xiao‐Xia Liu, Zhen‐Zhong Yang, Gesang Luobu, Baima Lamu, Dawa Ciren   +10 more
wiley   +1 more source

Obstructive Sleep Apnea is Associated with an Increased Prevalence of Polycythemia in Patients with Chronic Obstructive Pulmonary Disease

International Journal of COPD, 2022
Zhaofu Zeng, Yan Song, Xin He, Haizhen Yang, Fang Yue, Mengqing Xiong, Ke Hu Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, People’s Republic of ChinaCorrespondence: Ke HuDepartment of Respiratory and ...
Zeng Z, Song Y, He X, Yang H, Yue F, Xiong M, Hu K   +6 more
doaj  

Population Pharmacokinetics and Exposure–Response Analyses of Momelotinib, Its Active Metabolite (M21), and Total Active Moiety in Myelofibrosis

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 629-640, March 2026.
Momelotinib, a Janus kinase (JAK) 1/JAK2/activin A receptor type 1 inhibitor, is approved for the treatment of myelofibrosis with anemia. These analyses characterized the population pharmacokinetics of momelotinib and its active metabolite M21 following administration of the commercial tablet formulation in patients with myelofibrosis from phase II/III
Benjamin Rich, Meenakshi Srinivasan, Yu Liu Ho, Sandra A.G. Visser, Geraldine Ferron‐Brady, Georgios Vlasakakis   +5 more
wiley   +1 more source

Unraveling the role of TP53 mutations in myeloproliferative neoplasms: Molecular mechanisms of leukemic transformation

HemaSphere, Volume 10, Issue 3, March 2026.
Abstract TP53 mutations are found in over 50% of tumor types, including myeloproliferative neoplasms (MPNs). MPNs are characterized by a chronic phase, which may progress to secondary acute myeloid leukemia (sAML). Here, we discuss the physiological functions of p53 in hematopoiesis and its deregulation in MPNs.
Suzana da Silva‐Benedito, Paula Sabbo Bernardo, Jean‐Edouard Martin, Caroline Marty, Isabelle Plo, Iléana Antony‐Debré, Bárbara da Costa Reis Monte‐Mór   +6 more
wiley   +1 more source

Discordant Vitamin B12 Results in an IgA Nephropathy Patient

Journal of Clinical Laboratory Analysis, Volume 40, Issue 5, March 2026.
ABSTRACT Background Discordant Vitamin B12 results can result from immunoassay interferences, potentially leading to unnecessary diagnostic procedures and misdiagnoses if not properly recognized. Case Presentation A 76‐year‐old male with a history of IgA nephropathy, hypertension, and other comorbidities presented with unexpectedly elevated total ...
Oytun Portakal, Nazende Işlak, Muhammed Ş. Binici, Yahya Büyükaşik   +3 more
wiley   +1 more source

Validation of the Primerdesign Quantitative Allele Specific Amplification Kit for the Detection of JAK2V617F Mutation

Journal of Clinical Laboratory Analysis, Volume 40, Issue 6, March 2026.
The PrimerDesign Quasa kit demonstrates efficacy as a reliable assay for the detection of JAK2V617F mutation, exhibiting potential for quantitative analysis when samples are analysed in duplicate. This assay validation information may prove valuable to laboratories seeking to implement a simplified JAK2V617F mutational test. ABSTRACT Introduction Janus
Deborah Vaz, Tshiphiri Netshidzivhani, Johan Potgieter   +2 more
wiley   +1 more source

Society for Maternal‐Fetal Medicine Consult Series #75: Evaluation and management of non‐immune hydrops fetalis

Pregnancy, Volume 2, Issue 2, March 2026.
Abstract Non‐immune hydrops fetalis (NIHF) can result from a multitude of underlying causes, such as fetal genetic diseases, congenital anomalies, infections, fetal arrhythmias, placental tumors, monochorionic twin complications, and other disorders.
Society for Maternal‐Fetal Medicine (SMFM), Teresa. N. Sparks, Mary. E. Norton, SMFM Publications Committee   +3 more
wiley   +1 more source

Society for Maternal‐Fetal Medicine Special Statement: Updated checklists for management of monochorionic twin pregnancy

Pregnancy, Volume 2, Issue 2, March 2026.
Abstract Approximately 20% of twin pregnancies are monochorionic—either monochorionic/diamniotic (MC/DA) or monochorionic/monoamniotic (MC/MA). The management of monochorionic twin pregnancy involves several additional interventions beyond the routine management of singletons or dichorionic twins. In 2020, the Society for Maternal‐Fetal Medicine (SMFM)
Society for Maternal‐Fetal Medicine (SMFM), Ruofan Yao, Iffath Abbasi Hoskins, C. Andrew Combs, SMFM Patient Safety and Quality Committee   +4 more
wiley   +1 more source

Covariate Adjustment in Basket Trials Borrowing Information Across Subgroups

Statistics in Medicine, Volume 45, Issue 6-7, March 2026.
ABSTRACT Basket trials are an efficient approach to simultaneously evaluate a single therapy across multiple diseases where patients share a common molecular target. Bayesian hierarchical models (BHMs) are widely used to estimate the treatment effects while accounting for heterogeneity between patient subgroups within a basket trial.
Jiyang Ren, David S. Robertson, Haiyan Zheng   +2 more
wiley   +1 more source

Prediction of survival after fetoscopic laser surgery for early‐onset twin‐to‐twin transfusion syndrome

Ultrasound in Obstetrics &Gynecology, Volume 67, Issue 3, Page 295-303, March 2026.
ABSTRACT Objective Data on early‐onset twin‐to‐twin transfusion syndrome (TTTS) are scarce and, therefore, evidence‐based counseling and management of these pregnancies are challenging. This study aimed to investigate survival rates and establish predictors of survival after fetoscopic laser surgery (FLS) for early‐onset TTTS.
S. Prasad, F. G. Sileo, J. Binder, E. Brunelli, N. Chianchiano, C. M. Coutinho, F. D'Antonio, M. Döbert, A. Fichera, Y. Gielchinsky, K. Hecher, C. Iacovella, S. Malone, A. Martinez‐Varea, L. N. Nørgaard, C. Rodo, T. Simões, F. Slaghekke, Y. Yinon, A. Khalil, Collaborators, F. Bahlmann, E. Carreras, S. G. Alletti, O. Yaghi, E. Lopriore, M. M. Okido, A. Markovich, D. Mohammed, E. Moreno‐Perez, F. Prefumo, A. Queirós, J. M. Rosello, K. Sundberg, M. Yeoh, A. Youssef, C. O. Ulusoy   +36 more
wiley   +1 more source