Results 31 to 40 of about 303,632 (262)

Clonal analyses reveal associations of JAK2V617F homozygosity with hematologic features, age and gender in polycythemia vera and essential thrombocythemia

Haematologica, 2013
Subclones homozygous for JAK2V617F are more common and larger in patients with polycythemia vera compared to essential thrombocythemia, but their role in determining phenotype remains unclear.
Anna L. Godfrey, Edwin Chen, Francesca Pagano, Yvonne Silber, Peter J. Campbell, Anthony R. Green   +5 more
doaj   +1 more source

Benefit-risk profile of cytoreductive drugs along with antiplatelet and antithrombotic therapy after transient ischemic attack or ischemic stroke in myeloproliferative neoplasms [PDF]

, 2018
We analyzed 597 patients with myeloproliferative neoplasms (MPN) who presented transient ischemic attacks (TIA, n = 270) or ischemic stroke (IS, n = 327). Treatment included aspirin, oral anticoagulants, and cytoreductive drugs.
Arellano-Rodrigo, Eduardo, Barbui, Tiziano, Beggiato, Eloise, Bellini, Marta, Bertozzi, Irene, Betti, Silvia, Bonifacio, Massimiliano, Cacciola, Emma, Cacciola, Rossella, Carli, Giuseppe, Carobbio, Alessandra, Cattaneo, Daniele, Cazzola, Mario, Censori, Bruno, Cervantes, Francisco, Cortelezzi, Agostino, De Stefano, Valerio, Di Lazzaro, Vincenzo, Elli, Elena Maria, Ellis, Martin H., Finazzi, Guido, Finazzi, Maria Chiara, Gaidano, Gianluca, Gomez, Montse, Griesshammer, Martin, Guglielmelli, Paola, Hernandez-Boluda, Juan-Carlos, Iurlo, Alessandra, Loscocco, Giuseppe Gaetano, Lunghi, Francesca, Miroslava, Palova, Musolino, Caterina, Palandri, Francesca, Randi, Maria Luigia, Rapezzi, Davide, Rossi, Elena, Rumi, Elisa, Sadjadian, Parvis, Scaffidi, Luigi, Tieghi, Alessia, Vannucchi, Alessandro M., Vianelli, Nicola   +41 more
core   +5 more sources

Mouse models of myeloproliferative Neoplasms: JAK of all grades. (Review) [PDF]

, 2011
In 2005, several groups identified a single gain-of-function point mutation in the JAK2 kinase that was present in the majority of patients with myeloproliferative neoplasms (MPNs).
Li, J., Kent, D.G., Chen, E., Green, A.R., Li, J., Kent, D.G., Chen, E., Green, A.R.   +7 more
core   +2 more sources

Hereditary hemochromatosis and JAK2‐positive polycythemia vera

Clinical Case Reports, 2021
A 59‐year‐old man was diagnosed with JAK2‐positive polycythemia vera. Subsequently, further laboratory testing revealed elevated ferritin and iron saturation.
Ahmed Radwan, Ibraheem Othman
doaj   +1 more source

Double Thrombosis- Interesting Case of Polycythemia Vera [PDF]

Journal of Clinical and Diagnostic Research, 2020
Polycythemia vera is a myeloproliferative disorder which has a varied manifestation, one of it being venous thrombosis and arterial thrombosis which significantly contributes to the mortality and morbidity.
Subashini Subramanian, Siva Ranganathan Green   +1 more
doaj   +1 more source

The JAK2V617 mutation induces constitutive activation and agonist hypersensitivity in basophils from patients with polycythemia vera

Haematologica, 2009
Background The JAK2V617F mutation has been associated with constitutive and enhanced activation of neutrophils, while no information is available concerning other leukocyte subtypes.Design and Methods We evaluated correlations between JAK2V617F mutation ...
Lisa Pieri, Costanza Bogani, Paola Guglielmelli, Maria Zingariello, Rosa Alba Rana, Niccolò Bartalucci, Alberto Bosi, Alessandro M. Vannucchi   +7 more
doaj   +1 more source

Macrophages support pathological erythropoiesis in Polycythemia Vera and Beta-Thalassemia [PDF]

, 2014
Regulation of erythropoiesis is achieved by integration of distinct signals. Among these, macrophages are emerging as erythropoietin-complementary regulators of erythroid development, particularly under stress conditions. We investigated the contribution
Abdel-Wahab, Omar, Breda, Laura, Casu, Carla, Crielaard, Bart J., Ebert, Benjamin L., Gardenghi, Sara, Ghaffari, Saghi, Giardina, Patricia J., Grady, Robert W., Gupta, Ritama, Guy, Ella, Levine, Ross L., Marongiu, Maria Franca, Ramos, Pedro, Rivella, Stefano, Van Rooijen, Nico   +15 more
core   +1 more source

Familial polycythemia vera

Cleveland Clinic Journal of Medicine, 1989
The occurrence of polycythemia vera in a father, mother, and two sons is reported. Thirteen kindreds with familial polycythemia vera in 31 members are reviewed. Comprehensive records were available for all four patients as well as other family members, since all were diagnosed and treated at the author's institution over a period of nearly 50 years ...
R L, Miller, J D, Purvis, J K, Weick
openaire   +2 more sources

Aquagenic Pruritus in Polycythemia Vera: Clinical Characteristics

Acta Dermato-Venereologica, 2018
Aquagenic pruritus is one of the main clinical features of polycythemia vera. The aim of this study was to analyse the clinical characteristics of aquagenic pruritus.
Edyta Lelonek, Łukasz Matusiak, Tomasz Wróbel, Jacek C. Szepietowski   +3 more
doaj   +1 more source

Neutropenia caused by hairy cell leukemia in a patient with myelofibrosis secondary to polycythemia vera: a case report

Journal of Medical Case Reports, 2018
Background Polycythemia vera is a myeloproliferative disease that sometimes evolves to myelofibrosis, causing splenomegaly and neutropenia. In this case report, we describe a patient with polycythemia vera and unexplained neutropenia who later turned out
Andreas Hanssønn Habberstad, Hoa Thi Tuyet Tran, Ulla Randen, Signe Spetalen, Ingunn Dybedal, Geir E. Tjønnfjord, Anders Erik Astrup Dahm   +6 more
doaj   +1 more source