Results 91 to 100 of about 24,760 (225)

Natural Products Biosynthesis by Streptomyces netropsis IMV Ac-5025 under Exogenous Sterol Action

Antibiotics
Streptomycetes are known as producers of bioactive substances, particularly antibiotics. Streptomyces netropsis IMV Ac-5025 simultaneously produces different classes of antibiotics, including polyene compounds, phytohormones, and sterols, but the ...
Mariia Loboda, Liudmyla Biliavska, Galyna Iutynska, Jake Newitt, Ruslan Mariychuk   +4 more
doaj   +1 more source

The polyene macrolide antibiotics [PDF]

Postgraduate Medical Journal, 1979
Summary The mode of action of the polyene antibiotics is reviewed together with the effect of genetic and environmental factors on sensitive organisms. The future prospects of polyenes in the treatment of systemic mycoses are considered.
openaire   +2 more sources

Effect of Essential Phospholipids in Metabolic Dysfunction‐Associated Steatotic Liver Disease: A Randomised Phase 4 Clinical Trial

Liver International, Volume 46, Issue 5, May 2026.
ABSTRACT Background and Aims Metabolic dysfunction‐associated steatotic liver disease (MASLD) poses a significant health burden and impacts quality of life (QoL). This study evaluates the effects of essential phospholipids (EPL) on liver steatosis, QoL, and other liver and metabolic parameters in patients with MASLD and associated comorbidities ...
Norbert Stefan, Marek Hartleb, Jiangao Fan, Münevver Demir, Jörn M. Schattenberg, Jan Gietka, Łukasz Bułdak, Branko Popovic, Rafael Varona, Beatrice Bois De Fer   +9 more
wiley   +1 more source

MODELS OF AMPHOTERICIN MEMBRANE CHANNEL BASED ON CONCERTED INTERMOLECULAR =C-H…O INTERACTIONS [PDF]

Annals of Mechnikov's Institute, 2012
To study the possibility for amphotericin to form membrane channel via intermolecular interactions mimicing the association mode of polyene macrolides in crystal structures we have built two channel models in vacuo: amphotericin B octamer and hexamer ...
Lisnyak Yu. V
doaj  

HPLC-NMR Chemical Profiling and Dereplication Studies of the Marine Brown Alga,

Natural Product Communications, 2013
A chemical profiling/dereplication exercise, involving the use of HPLC-NMR and mass spectrometry in combination with the MarinLit database, was conducted on the crude dichloromethane extract of the southern Australian marine brown alga Cystophora ...
Sylvia Urban, Michael Timmers
doaj   +1 more source

Mechanistic Insights Into the Photosensitizing Properties of the Topical Retinoid Tazarotene

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Light‐activated retinoids: Tazarotene and its active metabolite tazarotenic acid form long‐lived triplet excited states upon UVA irradiation, generating singlet oxygen and promoting photochemical reactions. These processes correlate with reduced fibroblast viability under light exposure, revealing potential phototoxicity and implications for combined ...
Juan A. Soler‐Orenes, Macarena Dillon, Gemma M. Rodríguez‐Muñiz, Matilde Ansino‐Ortiz, Inmaculada Andreu, Virginie Lhiaubet‐Vallet   +5 more
wiley   +1 more source

Characterization of the biosynthetic gene cluster of the polyene macrolide antibiotic reedsmycins from a marine-derived Streptomyces strain

Microbial Cell Factories, 2018
Background Polyene antibiotics are important as antifungal medicines albeit with serious side effects such as nephrotoxicity. Reedsmycin (RDM) A (1), produced by marine-derived Streptomyces youssoufiensis OUC6819, is a non-glycosylated polyene macrolide ...
Tingting Yao, Zengzhi Liu, Tong Li, Hui Zhang, Jing Liu, Huayue Li, Qian Che, Tianjiao Zhu, Dehai Li, Wenli Li   +9 more
doaj   +1 more source

Structural Mechanism of an Efficacy Photoswitch Targeting the β2‐adrenergic Receptor

Angewandte Chemie International Edition, Volume 65, Issue 18, 27 April 2026.
Time‐resolved structures from x‐ray free‐electron laser measurements combined with cellular assays demonstrate how the photoswitchable β‐blocker photoazolol‐1 acts as an efficacy switch of β2‐adrenergic receptor function. Light‐induced ligand repositioning shifts activity from inverse agonism toward neutral antagonism by altering local helical ...
Robin Stipp, Quentin Bertrand, Matilde Trabuco, Anna Duran‐Corbera, Maria Tindara Ignazzitto, Hannah Glover, Fabienne Stierli, Juanlo Catena, Melissa Carrillo, Sina Hartmann, Hans‐Peter Seidel, Matthias Mulder, Thomas Mason, Yasushi Kondo, Maximillian Wranik, Martin Appleby, Christoph Sager, Raymond Sierra, Gregory Gate, Pamela Schleissner, Xinxin Cheng, Tobias Weinert, Robert Cheng, Sandra Mous, John H. Beale, Michal Kepa, Amadeu Llebaria, Michael Hennig, Xavier Rovira, Joerg Standfuss   +29 more
wiley   +1 more source

Aromaticity‐Induced Spin State Switching and High‐Spin States in Non‐Alternant Polyradicals

Journal of Computational Chemistry, Volume 47, Issue 10, 15 April 2026.
The peculiar topology of some non‐alternant systems allows such a degree of freedom in favored spin‐alignment between unpaired electrons that the polyradical can be in low‐, intermediate‐, and high‐spin ground state. Thus, the modulation of resonance energy upon distortions of pro‐aromatic units via external stimuli may result in switching the lowest ...
Sergi Betkhoshvili, Ibério de P. R. Moreira, Jordi Poater, Josep Maria Bofill   +3 more
wiley   +1 more source

Natamycin - antimycotic of polyene macrolides class with unusual properties

Vestnik Dermatologii i Venerologii, 2017
In the current literature review issues regarding physicochemical peculiarities, mechanism ot action and satety aspects ot polyene macrolides class compound natamycin are enlightened along with the extensive clinical data upon the use ot pharmaceuticals ...
I. O. Malova, D. D. Petrunin
doaj   +1 more source