Results 1 to 10 of about 226 (139)
Antibiotics, 2023 The biosynthesis of polyene macrolides, which are natural products produced by soil actinomycetes, have been extensively explored, and recent studies have focused on the effects of post–polyketide synthase (PKS) modifications to polyene macrolides on ...
Yao Dong, Hao Cui
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New Glycosylated Polyene Macrolides: Refining the Ore from Genome Mining
Antibiotics, 2022 Glycosylated polyene macrolides include effective antifungal agents, such as pimaricin, nystatin, candicidin, and amphotericin B. For the treatment of systemic mycoses, amphotericin B has been described as a gold-standard antibiotic because of its potent
Patrick Caffrey +2 more
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Sterol Sponge Mechanism Is Conserved for Glycosylated Polyene Macrolides [PDF]
ACS Central Science, 2021 Amphotericin-like glycosylated polyene macrolides (GPMs) are a clinically and industrially important family of natural products, but the mechanisms by which they exert their extraordinary biological activities have remained unclear for more than half a century.
Xiaorui Guo +2 more
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Polyene macrolide antifungal drugs trigger interleukin-1β secretion by activating the NLRP3 inflammasome. [PDF]
PLoS ONE, 2011 The use of antimycotic drugs in fungal infections is based on the concept that they suppress fungal growth by a direct killing effect. However, amphotericin and nystatin have been reported to also trigger interleukin-1β (IL-1β) secretion in monocytes but
Murthy Narayana Darisipudi +3 more
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Molecules, 2021 Phytopathogenic fungi infect crops, presenting a worldwide threat to agriculture. Polyene macrolides are one of the most effective antifungal agents applied in human therapy and crop protection. In this study, we found a cryptic polyene biosynthetic gene
Ying Tang +6 more
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PLoS ONE, 2020 Tetraene macrolides remain one of the most reliable fungicidal agents as resistance of fungal pathogens to these antibiotics is relatively rare. The modes of action and biosynthesis of polyene macrolides had been the focus of research over the past few ...
Jing-Xuan Fan +5 more
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Engineered Biosynthesis of Disaccharide-Modified Polyene Macrolides [PDF]
Applied and Environmental Microbiology, 2013 ABSTRACT Recent work has uncovered genes for two glycosyltransferases that are thought to catalyze mannosylation of mycosaminyl sugars of polyene macrolides. These two genes are nypY from Pseudonocardia sp.
Bernard Rawlings, Patrick Caffrey
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Effect of Polyene Macrolides on Cholesterol Metabolism of the Chick
Experimental Biology and Medicine, 1969 SummaryIt was shown that small concentrations of certain dietary polyene macrolides, and in particular the aromatic heptaenes, effectively reduce plasma cholesterol of cholesterolfed chicks, presumably through a mechanism which involves binding of lipids, particularly cholesterol, in the digestive tract.
H Fisher +2 more
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The polyene macrolide antibiotics [PDF]
Postgraduate Medical Journal, 1979 Summary The mode of action of the polyene antibiotics is reviewed together with the effect of genetic and environmental factors on sensitive organisms. The future prospects of polyenes in the treatment of systemic mycoses are considered.
openaire +4 more sources
Chemistry and Biology of the Polyene Macrolide Antibiotics [PDF]
Bacteriological Reviews, 1973 [This corrects the article on p. 166 in vol. 37, PMID: 4578757.].
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