Results 31 to 40 of about 226 (139)
Harnessing Microbial Interactions to Elicit the Production of Polyene Macrolides in Streptomyces [PDF]
, 2018 Since their discovery in the 1950s, polyene macrolides have been invaluable for treating life threatening fungal infections. Polyene antibiotics are unique because they target ergosterol, the fungal sterol, and disrupt the cellular processes that rely on
Laughlin, Mitchell
core
Engineered biosynthesis and characterization of disaccharide-pimaricin
Microbial Cell FactoriesBackground Disaccharide polyene macrolides exhibit superior water solubility and significantly reduced hemolytic toxicity compared to their monosaccharide counterparts, making them promising candidates for safer antifungal therapeutics. In this study, we
Xiaoshan Zuo +5 more
doaj +1 more source
Potentiation of antiviral activity of acyclovir by polyene macrolide antibiotics [PDF]
Antimicrobial Agents and Chemotherapy, 1984 The potentiation of the antiviral activity of acyclovir [9-[(2-hydroxyethoxy)methyl]guanine] by polyene macrolide antibiotics has been studied as a function of the macrolide structure. The 12 polyenes chosen for this study represented the major structural groups of these antibiotics and induced in mammalian cells repairable membrane alterations or ...
B, Malewicz +3 more
openaire +2 more sources
, 2016 New derivatives of Amphotericin B (AmB) were synthesized through a double reductive alkylation of the mycosamine. These derivatives of AmB displayed superior antifungal activity against Saccharomyces cerevisiae wild-type strain and especially in the case
Valérie Paquet (2519578) +1 more
core +1 more source
International Journal of Microbiology, Volume 2026, Issue 1, 2026.Many antibiotics originate from soil‐inhabiting Actinobacteria, especially from the diverse genus Streptomyces. However, the emergence of antibiotic resistance poses a significant global challenge to treating infectious diseases. Therefore, the search for Actinobacteria, particularly from less‐explored environments, as potential sources of novel ...
Rajani Balkrishna Rao +6 more
wiley +1 more source
, 2016 Although polyene macrolides are efficient antifungal agents with fungicidal mode of action, their use in medical practice is problematic due to their low solubility and significant human toxicity.
Håvard Sletta (698085) +5 more
core +1 more source
Synthetic and Systems BiotechnologyDigitoxose, a significant 2,6-dideoxyhexose found in nature, exists in many small-molecule natural products. These digitoxose-containing natural products can be divided into steroids, macrolides, macrolactams, anthracyclines, quinones, enediynes, acyclic
Kemeng Li, Zhengyan Guo, Liping Bai
doaj +1 more source
Jornal de Pediatria, 2005 OBJETIVO: Rever as mais recentes publicações sobre infecção fúngica no recém-nascido de muito baixo peso ao nascer, com objetivo de fornecer aos profissionais de saúde atualização sobre um crescente problema nas unidades neonatais.
Maria E. L. Moreira
doaj +1 more source
Modular Synthesis of Dihydropyranones through Cyclization and Organometallic Functionalization
European Journal of Organic Chemistry, Volume 28, Issue 48, December 22, 2025.A scalable method for synthesizing 3‐methoxy‐4,5‐dihydropyran‐2‐ones (MeO‐DHP‐2‐ones) via base‐promoted cyclization of hydroxy alkynes is presented. Mechanistic and computational studies guided the transformation into 4,5‐dihydropyran‐4‐ones (DHP‐4‐ones), enabling access to spiroacetal precursors relevant to natural product synthesis.
Markéta Fuksová +5 more
wiley +1 more source
, 2011 Polyene macrolide antibiotics, including nystatin and amphotericin B, possess fungicidal activity and are being used as antifungal agents to treat both superficial and invasive fungal infections.
Håvard Sletta +8 more
core +1 more source