Results 21 to 30 of about 226 (139)

Molecular Control of Polyene Macrolide Biosynthesis [PDF]

Journal of Biological Chemistry, 2011
Control of polyene macrolide production in Streptomyces natalensis is mediated by the transcriptional activator PimM. This regulator, which combines an N-terminal PAS domain with a C-terminal helix-turn-helix motif, is highly conserved among polyene biosynthetic gene clusters.
Santos-Aberturas, Javier, Vicente, Cláudia M, Guerra, Susana, Payero, Tamara, Martin, Juan, Aparicio, Jesús   +5 more
openaire   +1 more source

Therapeutic potential of marine macrolides: An overview from 1990 to 2022 [PDF]

, 2022
Financiado para publicación en acceso aberto: Universidade de Vigo/CISUGThe sea is a vast ecosystem that has remained primarily unexploited and untapped, resulting in numerous organisms.
Jesus Simal-Gandara, Karthika Pushparaj, Rauf, Abdur, Pushparaj, Karthika, Meyyazhagan, Arun, Chunpeng Craig Wan, Abdur Rauf, Zidan Khan, Rajib Das, Khan, Zidan, Md Jamal Hossain, Das, Rajib, Wan, Chunpeng Craig, Saima Naz, Saikat Mitra, Bashir Ahmad, Emran, Talha Bin, Simal Gándara, Jesús, Talha Bin Emran, Arun Meyyazhagan, Mitra, Saikat, Kannan RR. Rengasamy, Rengasamy, Kannan RR., Balamuralikrishnan Balasubramanian, Balasubramanian, Balamuralikrishnan, Hossain, Md Jamal, Ahmad, Bashir, Naz, Saima   +27 more
core   +1 more source

Antibiotic-sterol interactions provide insight into the selectivity of natural aromatic analogues of amphotericin B and their photoisomers

Scientific Reports, 2023
Aromatic heptaene macrolides (AHMs) belong to the group of polyene macrolide antifungal antibiotics. Members of this group were the first to be used in the treatment of systemic fungal infections.
Julia Borzyszkowska-Bukowska, Jacek Czub, Paweł Szczeblewski, Tomasz Laskowski   +3 more
doaj   +1 more source

Fluorescent Probes Derived from the Polyene Class of Antifungal Drugs Reveal Distinct Localization Patterns and Resistance‐Associated Vacuolar Sequestration in Candida Species

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Fluorescent probes derived from all three clinically used polyene antifungals (amphotericin B, nystatin, and natamycin) enabled direct visualization of distribution in yeast cells of various Candida species. While retaining the ergosterol‐dependent mode of action of their parent drugs, the probes revealed distinct, structure‐specific localization ...
Melissa Shbeta, Tal Kopp, Ivan Voronov, Adi Yona, Rania Hasib Afana, Shmuel Carmeli, Micha Fridman   +6 more
wiley   +2 more sources

Genome mining reveals the biosynthetic potential of the marine-derived strain Streptomyces marokkonensis M10

Synthetic and Systems Biotechnology, 2016
Marine streptomycetes are rich sources of natural products with novel structures and interesting biological activities, and genome mining of marine streptomycetes facilitates rapid discovery of their useful products.
Liangyu Chen, Ying-Mi Lai, Yu-Liang Yang, Xinqing Zhao   +3 more
doaj   +1 more source

Stimulated Biosynthesis of an C10-Deoxy Heptaene NPP B2 via Regulatory Genes Overexpression in Pseudonocardia autotrophica

Frontiers in Microbiology, 2020
Polyene macrolides, such as nystatin A1, amphotericin B, and NPP A1, belong to a large family of valuable antifungal polyketide compounds that are typically produced by soil actinomycetes.
Heung-Soon Park, Hye-Jin Kim, Chi-Young Han, Hee-Ju Nah, Si-Sun Choi, Eung-Soo Kim   +5 more
doaj   +1 more source

Controlled delivery of membrane proteins to artificial lipid bilayers by nystatin-ergosterol modulated vesicle fusion

, 2006
The study of ion channels and other membrane proteins and their potential use as biosensors and drug screening targets require their reconstitution in an artificial membrane.
Fisher, K.H., Berry, RM, Fisher, K H, Berry, R M, de Planque, MR, de Planque, M R R, Sandison, ME, Watts, A, Mendes, G P, Morgan, Hywel, Watts, A., Berry, Richard, Sandison, M E, de Planque, M.R.R., Sandison, Mairi E., Mendes, GP, Zagnoni, M, Zagnoni, Michele, Watts, Anthony, Berry, R.M., Morgan, H, Mendes, G.P., Fisher, KH   +22 more
core   +1 more source

Multi‐Omic Assessment of Microbial Communities and Their Polyketide Biosynthetic Potential Across Abyssal Sediments

Environmental Microbiology, Volume 28, Issue 5, May 2026.
Abyssal sediments were assessed for taxonomic diversity and polyketide biosynthetic potential and compared to metagenomic and metabolomic assessments of the same sediments. Biodiversity differences were documented across biogeochemical regimes with the results providing baseline awareness of what might be lost should deep‐sea microbiomes be disrupted ...
Hans W. Singh, Johanna Gutleben, Alexander Bogdanov, Alexander B. Chase, Alyssa Demko, Sheila Podell, Brian Haley, Paul R. Jensen   +7 more
wiley   +1 more source

Integrated Multi‐Omics Analysis of a Periplaneta americana Symbiont Streptomyces sampsonii Strain WA1‐19 Against Candida albicans

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
An integrated multi‐omics methodology was established in this study to implement a hazard‐to‐solution paradigm, valorizing a Streptomyces sampsonii strain WA1‐19 isolated from Periplaneta americana as a sustainable bioresource for Candida albicans biocontrol.
Zhiyu Chen, Wendi Mei, Jiale Tan, Lijun Wang, Jie Wang, Wenbin Liu, Chengzhang Pang, Xiaobao Jin   +7 more
wiley   +1 more source

A Comprehensive Review of Acne Treatments: Unpacking the Chemical Structures and Effective Bioactive Compounds

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background and Aims Acne vulgaris is a frequent skin disorder, affecting a large part of the population worldwide, and strongly influencing not only the physical but also the mental aspects of health. The choice of therapy for acne vulgaris is a very difficult one because the multifactorial causality of the disease and interindividual ...
Mobina Tajdari, Setare Abolghasemi, Elham Khanniri, Maryam Bayanati, Rahil Hakimimofrad, Mohammad Mahboubi‐Rabbani   +5 more
wiley   +1 more source