Results 11 to 20 of about 226 (139)

Natamycin - antimycotic of polyene macrolides class with unusual properties

Vestnik Dermatologii i Venerologii, 2017
In the current literature review issues regarding physicochemical peculiarities, mechanism ot action and satety aspects ot polyene macrolides class compound natamycin are enlightened along with the extensive clinical data upon the use ot pharmaceuticals ...
I. O. Malova, D. D. Petrunin
doaj   +2 more sources

Rare Polyene-polyol Macrolides from Mangrove-derived Streptomyces sp. ZQ4BG

Scientific Reports, 2017
Bioactive natural products from mangrove-derived actinomycetes are important sources for discovery of drug lead compounds. In this study, an extract prepared from culture of an actinomycete Streptomyces sp. ZQ4BG isolated from mangrove soils was found to
Wenling Wang, Tengfei Song, Weiyun Chai, Lu Chen, Lei Chen, Xiao-Yuan Lian, Zhizhen Zhang   +6 more
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Pentaene macrolides AB023a and takanawaene C produced by Streptomyces xanthocidicus strain S3 for controlling pepper anthracnose

Applied Biological Chemistry, 2023
A natural product library consisting of the culture extracts of 814 actinomycete strains was screened for antifungal compounds that disrupt the cell integrity of plant pathogenic fungi using an adenylate kinase (AK) assay system.
Byeong Jun Jeon, Ji Eun Kang, Jeong Do Kim, Beom Seok Kim   +3 more
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Antibiotic Loaded Phytosomes as a Way to Develop Innovative Lipid Formulations of Polyene Macrolides

Pharmaceutics
Background: The threat of antibiotic resistance of fungal pathogens and the high toxicity of the most effective drugs, polyene macrolides, force us to look for new ways to develop innovative antifungal formulations.
Svetlana S. Efimova, Olga S. Ostroumova
doaj   +2 more sources

PimT, an amino acid exporter controls polyene production via secretion of the quorum sensing pimaricin-inducer PI-factor in Streptomyces natalensis

Microbial Cell Factories, 2009
Background Polyenes represent a major class of antifungal agents characterised by the presence of a series of conjugated double bonds in their planar hydroxylated macrolide ring structure.
Guerra Susana M, Santos-Aberturas Javier, Vicente Cláudia M, Payero Tamara D, Martín Juan F, Aparicio Jesús F   +5 more
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MODELS OF AMPHOTERICIN MEMBRANE CHANNEL BASED ON CONCERTED INTERMOLECULAR =C-H…O INTERACTIONS [PDF]

Annals of Mechnikov's Institute, 2012
To study the possibility for amphotericin to form membrane channel via intermolecular interactions mimicing the association mode of polyene macrolides in crystal structures we have built two channel models in vacuo: amphotericin B octamer and hexamer ...
Lisnyak Yu. V
doaj   +1 more source

Self-assembled nanostructures of L-ascorbic acid alkyl esters support monomeric amphotericin B

Heliyon, 2021
Hypothesis: Amphotericin B (AmB) is a highly effective antimicrobial, with broad antimycotic and antiparasitic effect. However, AmB poor water-solubilisation and aggregation tendency limits its use for topical applications.
Natalia E. Nocelli, Yenisleidy de las Mercedes Zulueta Díaz, Marine Millot, María Luz Colazo, Raquel V. Vico, Maria Laura Fanani   +5 more
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Iso-Partricin, an Aromatic Analogue of Amphotericin B: How Shining Light on Old Drugs Might Help Create New Ones

Antibiotics, 2021
Partricin is a heptaene macrolide antibiotic complex that exhibits exceptional antifungal activity, yet poor selective toxicity, in the pathogen/host system.
Paweł Szczeblewski, Justyna Górska, Witold Andrałojć, Patryk Janke, Karolina Wąsik, Tomasz Laskowski   +5 more
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Current State‐of‐the‐Art Toward Chemoenzymatic Synthesis of Polyketide Natural Products

ChemBioChem, Volume 24, Issue 21, November 2, 2023., 2023
Polyketides represent an area of significant interest for drug discovery efforts. Leveraging a combination of chemical synthesis and enzymology, researchers have routinely demonstrated that the best of both strategies are conferred and result in improved outcomes.
Thaddeus Q. Paulsel, Gavin J. Williams
wiley   +1 more source

Polyene-Producing Streptomyces spp. From the Fungus-Growing Termite Macrotermes barneyi Exhibit High Inhibitory Activity Against the Antagonistic Fungus Xylaria

Frontiers in Microbiology, 2021
Fungus-growing termites are engaged in a tripartite mutualism with intestinal microbes and a monocultivar (Termitomyces sp.) in the fungus garden. The termites are often plagued by entomopathogen (Metarhizium anisopliae) and fungus garden is always ...
Jingjing Li, Moli Sang, Yutong Jiang, Jianhua Wei, Yulong Shen, Qihong Huang, Yaoyao Li, Yaoyao Li, Jinfeng Ni   +8 more
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