Results 41 to 50 of about 226 (139)

Novel Kidney Biomarkers and Antibiotics‐Induced Acute Kidney Injury: A Practical Assessment of Current and Future Applications

Clinical and Translational Science, Volume 18, Issue 12, December 2025.
ABSTRACT Several antibiotics have nephrotoxic potential and an undeniable role in the development of acute kidney injury (AKI). The current AKI definition and operational criteria are dependent on functional biomarkers, serum creatinine and urine output, to identify and quantify kidney dysfunction and injury.
Iman Karimzadeh, Sandra L. Kane‐Gill
wiley   +1 more source

The Discovery of Fungal Polyene Macrolides via a Postgenomic Approach Reveals a Polyketide Macrocyclization by trans-Acting Thioesterase in Fungi

, 2019
Heterologous expression of a unique biosynthetic gene cluster (BGC) comprising a highly reducing polyketide synthase and stand-alone thioesterase genes in Aspergillus oryzae enabled us to isolate a novel 34-membered polyene macrolide, phaeospelide A (1).
Yohei Morishita (5819357), Huiping Zhang (135186), Tohru Taniguchi (1403230), Teigo Asai (1915987), Keiji Mori (1835440)   +4 more
core   +1 more source

Antibiotic Resistance: A Genetic and Physiological Perspective

MedComm, Volume 6, Issue 11, November 2025.
The development of resistance to antimicrobials and their historical progression are depicted in this graphic. It draws attention to important biochemical, physiological, and genetic factors that contribute to AMR, such as the transmission of genes, the development of biofilms, and the inactivation of antibiotics.
Rania G. Elbaiomy, Ahmed H. El‐Sappah, Rong Guo, Xiaoling Luo, Shiyuan Deng, Meifang Du, Xiaohong Jian, Mohammed Bakeer, Zaixin Li, Zhi Zhang   +9 more
wiley   +1 more source

The effect of some polyene macrolides on absorption from the small intestine in the rat

, 1976
The effect of three polyene macrolides, candicidin, amphotericin B and nystatin on the absorption of [3H]cholesterol was studied in the rat by using the in situ gut loop perfusion technique.
J Chakraborty, V Marks, J English
core   +1 more source

Antiviral Activity of Polyene Macrolides Against Newcastle Disease Virus: Computational and Experimental Insights

Molecules
The search for novel antiviral agents against Newcastle disease virus (NDV) remains a priority in industrial poultry farming due to the virus’s high contagiousness and associated economic losses, prompting evaluation of polyene macrolides as potential ...
Aidar Mukhametkaliyev, Andrey Bogoyavlenskiy, Pavel Alexyuk, Madina Alexyuk, Nadezhda Sokolova, Yergali Moldakhanov, Kuralay Akanova, Aziza Temirbayeva, Assilbek Mussoyev, Krzysztof Śmietanka, Vladimir Berezin   +10 more
doaj   +1 more source

Antifungal Activity, Cytocompatibility, and Wound Healing Potential of Novel Mucoadhesive Formulations for Oral Drug Delivery

Journal of Biomedical Materials Research Part A, Volume 113, Issue 10, October 2025.
ABSTRACT Conventional treatments for oral candidiasis often fail due to the complexities of the oral environment and the increasing antifungal drug resistance. Therefore, there is a growing demand for new therapies that optimize drug bioavailability, allowing for lower therapeutic doses while enhancing cytocompatibility, maintaining antifungal, anti ...
Carolina Yoshi Campos Sugio, Victor Martin, Lídia Maria Diogo Gonçalves, Priscileila Coleto Ferrari, Vanessa Migliorini Urban, Karin Hermana Neppelenbroek, Maria Helena Fernandes   +6 more
wiley   +1 more source

Research and Application of the Polyene Macrolide Antibiotic Nystatin

Molecules
Nystatin is a polyene macrolide antibiotic with broad-spectrum antifungal activity and serves as a key therapeutic agent for superficial fungal infections. This review systematically elaborates on its multicomponent chemical nature, its mechanism of action targeting ergosterol, and highlights the potential adverse effects, such as cardiotoxicity ...
Xiaofeng Liu, Jiamin Zhuo, Zherui Chen, Yao Zhang, Wei Jiang, Rongfa Guan   +5 more
openaire   +2 more sources

Integration of Machine Learning‐QSAR and Polypharmacology in Drug Discovery for Leishmaniasis Using Natural and Repurposed Compounds

ChemistrySelect, Volume 10, Issue 21, June 4, 2025.
Leishmaniasis affects over 1 billion people worldwide, with current treatments limited by toxicity and efficacy. This study used machine learning (ML), QSAR, and polypharmacology to identify potential drug candidates, analyzing 12,072 compounds with random forest and XGBoost models.
Laís Salvador do Amaral, Amiel Artur Morais, Alexandre de Fátima Cobre, Raul Edison Luna Lazo, Dile Pontarolo Stremel, Jaqueline Carneiro, Luana Mota Ferreira, Roberto Pontarolo   +7 more
wiley   +1 more source

Biosynthetic engineering of polyene macrolides for generation of improved antifungal and antiparasitic agents

, 2017
Polyene macrolides are potent antifungal agents that are also active against parasites, enveloped viruses and prion diseases. They are medically important as antifungal antibiotics but their therapeutic use is limited by serious side effects.
Malpartid, Francisco, Zotchev, Sergey B., Aparicio, Jesus F., Caffrey, Patrick   +3 more
core   +1 more source

Promoter Engineering Reveals the Importance of Heptameric Direct Repeats for DNA Binding by Streptomyces Antibiotic Regulatory Protein–Large ATP-Binding Regulator of the LuxR Family (SARP-LAL) Regulators in Streptomyces natalensis [PDF]

, 2018
International audienceThe biosynthesis of small-size polyene macrolides is ultimately con-trolled by acouple of transcriptional regulators that act in a hierarchical way.
Antonio de Pedro, Cláudia M. Vicente, Jesús F. Aparicio, Barreales, Eva, Javier Santos-Aberturas, de Pedro, Antonio, Santos-Aberturas, Javier, Aparicio, Jesús, Eva G. Barreales, Vicente, Cláudia M   +9 more
core   +2 more sources