Results 61 to 70 of about 226 (139)

Treatment of mucocutaneous leishmaniasis – A systematic review

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 22, Issue 6, Page 763-773, June 2024.
Summary Mucocutaneous leishmaniasis is a severe infectious disease, predominantly endemic in Central and South America and is characterized by granulomatous, destructive mucosal lesions in the oral, nasal, and pharyngeal cavities. It is caused by protozoa of the genus Leishmania spp. transmitted to humans by sandflies.
Theresa Fischer, Marcellus Fischer, Sibylle Schliemann, Peter Elsner   +3 more
wiley   +1 more source

Marine Macrolides, a Promising Source of Antitumor Compounds

, 2009
Marine organisms have attracted scientific community as a rich source of natural products with unusual structural features and remarkable biological activities.
Hernández Daranas, Antonio, Norte, Manuel, Napolitano, Jose G., Fernández, José J.   +3 more
core   +1 more source

Characterisation of Modular Polyketide Synthases Designed to Make Pentaene Analogues of Amphotericin B

Molecules
Glycosylated polyene macrolides are important antifungal agents that are produced by many actinomycete species. Development of new polyenes may deliver improved antibiotics.
Yuhao Song, Mark Hogan, Jimmy Muldoon, Paul Evans, Patrick Caffrey   +4 more
doaj   +1 more source

What is the role of microbial biotechnology and genetic engineering in medicine?

MicrobiologyOpen, Volume 13, Issue 2, April 2024.
Microbial biotechnology, the technological application of microorganisms, has been instrumental in producing significant natural bioactive products. These include antibiotics, antifungals, anticancer drugs, antiparasitics, antivirals, immunosuppressants, toxoid vaccines, and therapeutic enzymes.
Fernando Santos‐Beneit
wiley   +1 more source

Synthesis and function of the conserved motif of mycosamine-containing polyene macrolides [PDF]

, 2012
Mycosamine-containing polyene macrolides represent a large family of natural products with antifungal activity, of which amphotericin B (AmB) is an important member.
Dailey, Ian
core  

Two Polyene Amides Produced by Genetically Modified Streptomyces diastaticus var. 108

, 2005
SummaryStreptomyces diastaticus var. 108, a newly isolated strain, was recently characterized as a producer of two polyene macrolide antibiotics (rimocidin and CE-108), and the biosynthetic gene cluster was partially characterized.
Fotso, Serge, Laatsch, Hartmut, Cuesta, Trinidad, Malpartida, F., Malpartida, Francisco, Seco, Elena M., Cuesta, T.   +6 more
core   +1 more source

Recognition of Membrane Sterols by Polyene Antifungals Amphotericin B and Natamycin, A 13C MAS NMR Study [PDF]

, 2016
The molecular action of polyene macrolides with antifungal activity, amphotericin B and natamycin, involves recognition of sterols in membranes. Physicochemical and functional studies have contributed details to understanding the interactions between ...
Griffin, DC, Ciesielski, F, Rittig, M, Bonev, BB, Delves-Broughton, J, Loraine, J   +5 more
core   +3 more sources

Isolation, structure revision and stereochemistry of trichomycins A and B, aromatic analogues of amphotericin B

Scientific Reports
Fungal infections pose an increasing global health threat, particularly to immunocompromised individuals. In response, the World Health Organization has prioritized the development of new antifungal agents.
Tomasz Laskowski, Filip Anaszewicz, Julia Borzyszkowska-Bukowska, Julia Pakuła, Małgorzata Michałowska, Julia Bublewska, Dorota Gudanis-Sobocińska, Katarzyna Kozłowska-Tylingo, Paweł Szczeblewski   +8 more
doaj   +1 more source

Boron’s Double Edge—Antibiotics, Toxins, and the Fine Line Between Them

Molecules
Boron is a chemically distinctive bioelement whose electron-deficient structure enables reversible coordination with oxygen-rich functional groups such as diols and hydroxyls.
Valery M. Dembitsky, Alexander O. Terent'ev, Sergey V. Baranin, Ion Romulus Scorei   +3 more
doaj   +1 more source

Biosynthesis and pathway engineering of antifungal polyene macrolides in actinomycetes

Journal of Industrial Microbiology and Biotechnology, 2013
Abstract Polyene macrolides are a large family of natural products typically produced by soil actinomycetes. Polyene macrolides are usually biosynthesized by modular and large type I polyketide synthases (PKSs), followed by several steps of sequential post-PKS modifications such as region-specific oxidations and glycosylations.
Dekun, Kong, Mi-Jin, Lee, Shuangjun, Lin, Eung-Soo, Kim   +3 more
openaire   +2 more sources