Results 71 to 80 of about 226 (139)

A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis

, 2000
Background: Polyene macrolides are a class of large macrocyclic polyketides that interact with membrane sterols, having antibiotic activity against fungi but not bacteria.
Jesús F Aparicio, Olivera, Noemı́, Roberto Fouces, Juan F Martı́n, Aparicio, Jesús F, Mendes, Marta V, Noemı́ Olivera, Marta V Mendes, Martı́n, Juan F, Fouces, Roberto   +9 more
core   +1 more source

Improved recovery and biological activities of an engineered polyene NPP analogue in Pseudonocardia autotrophica

, 2017
NPP A1 produced by Pseudonocardia autotrophica is a unique disaccharide-containing polyene macrolide. NPP A1 was reported to have higher water solubility and lower hemolytic toxicity than nystatin A1 while retaining its antifungal activity. An engineered
Hye-Jin Kim, Seung-Hoon Kang, Eung-Soo Kim, Jin-Young Jang, Si-Sun Choi, Hyung-Jin Won   +5 more
core   +1 more source

Exploration of the substrate promiscuity of biosynthetic tailoring enzymes as a new source of structural diversity for polyene macrolide antifungals

, 2014
Even though there is an urgent need for new antifungals with improved clinical properties, the substrate promiscuity of tailoring enzymes has been poorly studied as a source of new structural diversity for polyene macrolides. We explore the acceptance of
Rudroff, Florian, Bornscheuer, Uwe T., Dickerhoff, Jonathan, Santos-Aberturas, Javier, Engel, Jennifer, Dorr, Mark, Weisz, Klaus   +6 more
core  

Engineered biosynthesis of novel polyenes: a pimaricin derivative produced by targeted gene disruption in Streptomyces natalensis

, 2001
Background: The post-polyketide synthase biosynthetic tailoring of polyene macrolides usually involves oxidations catalysed by cytochrome P450 monooxygenases (P450s).
Recio, Eliseo, Jesús F Aparicio, Eliseo Recio, Ruud Luiten, Luiten, Ruud, Roberto Fouces, Juan F Martı́n, Mendes, Marta V, Aparicio, Jesús F, Marta V Mendes, Martı́n, Juan F, Fouces, Roberto   +11 more
core   +1 more source

Glycosylated Polyene Macrolides Kill Fungi via a Conserved Sterol Sponge Mechanism of Action

ACS Central Science, 2021
Nicole M. Revie, Leah E. Cowen
doaj   +1 more source

PART 1: APPLICATION OF MICROBIAL REDUCTION: SYNTHETIC STUDIES OF PSEUDOGUIANOLIDES. PART 2: SYNTHETIC STUDIES OF POLYENE MACROLIDES (ASYMMETRIC SYNTHESIS, ENZYMATIC, SOLID STATE NMR, PIMARICIN)

, 1985
The pseudoguaianolides are a group of sesquiterpenes which exhibit cytotoxic and antitumor activity. Their principle structural feature is a 5,7-fused ring; Chapter 1 presents a review of successful racemic approaches to this hydroazulene system.
PALMER, JAMES CHRISTIAN TOBY
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Synthesis of gum Arabic-natamycin conjugate [PDF]

, 2012
In this work, natamycin, a polyene antibiotic belonging to the family of macrolides, was coupled to the periodate oxidized polysaccharide gum Arabic.
Gojgić-Cvijović, Gordana, Jakovljević, Dragica, Stefanović, Jovana, Vrvić, Miroslav   +3 more
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Evolutionary Reprogramming of Acyltransferase Domains in Polyene Macrolide Pathways

Microorganisms
The evolution of type I polyketide synthase (T1PKS) assembly lines remains poorly understood. Through systematic mining of polyene biosynthetic gene clusters, we identified a novel eurocidin biosynthetic pathway capable of producing identical compounds with divergent loading module architectures, thereby capturing an evolutionary transitional state ...
Zhang, Liran, Ren, Jinwei, Zhang, Chengyu, Zhang, Lixin, Wang, Bin, Zhang, Jingyu   +5 more
openaire   +3 more sources

Synthesis of the C15−C35 Northern Hemisphere Subunit of the Chivosazoles

, 2016
An advanced C15−C35 subunit of the chivosazole polyene macrolides was prepared in a convergent manner, exploiting boron-mediated aldol reactions for the stereocontrolled construction of the C15−C26 and C27−C35 segments, followed by their Pd/Cu-promoted ...
Ian Paterson (1297353), Lisa J. Gibson (2246839), S. B. Jennifer Kan (2246836)   +2 more
core   +1 more source

Macrolides: a bibliographic review [PDF]

39 págs., figuras y referencias bibliográficas[ES] La resistencia bacteriana hacia los antibióticos es un problema creciente que requiere de un cambio en los fármacos que conocemos hoy en día.
Fernández Colsa, Celia
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