Results 81 to 90 of about 226 (139)

A polyene macrolide targeting phospholipids in the fungal cell membrane

Nature
The global spread of multidrug-resistant pathogenic fungi presents a serious threat to human health, necessitating the discovery of antifungals with unique modes of action1. However, conventional activity-based screening for previously undescribed antibiotics has been hampered by the high-frequency rediscovery of known compounds and the lack of new ...
Qisen Deng, Yinchuan Li, Wenyan He, Tao Chen, Nan Liu, Lingman Ma, Zhixia Qiu, Zhuo Shang, Zongqiang Wang   +8 more
openaire   +2 more sources

Generation of New Glycoanalogues of Polyene Antibiotics by Synthetic Biology—Testing Current Technical Boundaries

A number of antifungal drugs are based on polyene macrolides that cause severe side effects. Most of these compounds contain a single aminodeoxysugar, D-mycosamine. Toxicity can be reduced by increasing the extent of glycosylation.
Mark Hogan, Yuhao Song, Patrick Caffrey, Jimmy Muldoon   +3 more
core   +1 more source

Polyene Macrolide Antifungal Drugs Trigger Interleukin- 1b Secretion by Activating the NLRP3 Inflammasome

, 2011
The use of antimycotic drugs in fungal infections is based on the concept that they suppress fungal growth by a direct killing effect. However, amphotericin and nystatin have been reported to also trigger interleukin-1b (IL-1b) secretion in monocytes but
Ramanjaneyulu Allam, Murthy Narayana Darisipudi, Khader Valli Rupanagudi   +2 more
core  

Initiation of Polyene Macrolide Biosynthesis: Interplay between Polyketide Synthase Domains and Modules as Revealed via Domain Swapping, Mutagenesis, and Heterologous Complementation

, 2011
Polyene macrolides are important antibiotics used to treat fungal infections in humans. In this work, acyltransferase (AT) domain swaps, mutagenesis, and cross-complementation with heterologous polyketide synthase domain (PKS) loading modules were ...
Sondre Heia, Håvard Sletta, Sven E. F. Borgos, Trond E. Ellingsen, Elena M. Seco, Leticia Escudero, Sergey B. Zotchev, Francisco Malpartida   +7 more
core   +1 more source

POLYENE MACROLIDE DERIVATIVES. I

The Journal of Antibiotics, 1972
WITOLD MECHLINSKI, CARL P. SCHAFFNER
openaire   +2 more sources

Studies on polyene macrolide synthesis with emphasis on the syntheses of the C-21 to C-37 and the C-1 to C-20 fragments of nystatin A(1)

, 1993
The total synthesis of nystatin A$\sb1$ was attempted and methods for the stereoselective construction of polyhydroxylated chains of polyene macrolides were explored.
Arbanasin, Katherine Antonia
core  

POLYENE MACROLIDE DERIVATIVES. III

The Journal of Antibiotics, 1972
DANIEL P. BONNER, WITOLD MECHLINSKI, CARL P. SCHAFFNER   +2 more
openaire   +2 more sources

Studies directed toward the total synthesis of amphotericin B

, 1988
The polyene macrolide antibiotics are endowed with a unique structure, being composed of a highly functionalized macrocyclic lactone, which incorporates on opposing sides both a lipophilic polyene and hydrophilic polyol carbon chain.
Kellogg, Rosemary Pacherille
core  

Mechanisms underlying polyene macrolide mediated rescue of growth in ion channel deficient yeast [PDF]

, 2018
Human diseases caused by missing or dysfunctional protein ion channels, known as channelopathies, affect several organs and systems of the body including that of the heart, lungs, kidneys, and nervous system. Channelopathies can result in devastating and
Hou, Jennifer
core  

Mechanisms underlying polyene macrolide mediated rescue of growth in ion channel deficient yeast

, 2020
Human diseases caused by missing or dysfunctional protein ion channels, known as channelopathies, affect several organs and systems of the body including that of the heart, lungs, kidneys, and nervous system. Channelopathies can result in devastating and
Hou, Jennifer
core