Results 51 to 60 of about 226 (139)

Total Synthesis of the Polyene-Polyol Macrolide RK-397, Featuring Cross-Couplings of Alkynylepoxide Modules

open access: yes, 2016
The total synthesis of the natural product RK-397 is based on a new synthetic strategy for assembling polyacetate structures, by efficient cross-coupling of nucleophilic terminal alkyne modules with electrophilic epoxides bearing another alkyne at the ...
Svetlana A. Burova (2740570)   +1 more
core   +2 more sources

Medical Potential of Insect Symbionts

open access: yesInsects
Insect symbionts and their metabolites are complex and diverse and are gradually becoming an important source of new medical materials. Some culturable symbionts from insects produce a variety of active compounds with medical potential. Among them, fatty
Fanglei Fan   +5 more
doaj   +1 more source

New insights into polyene macrolide biosynthesis in Couchioplanes caeruleus [PDF]

open access: yesMolecular BioSystems, 2017
Abstract Couchioplanes caeruleus DSM43634 synthesises 67–121C, an aromatic heptaene macrolide that contains a mannosyl-mycosaminyl disaccharide. An improved draft genome sequence was used to obtain the biosynthetic gene cluster for this antifungal.
J Sheehan, C D Murphy, P Caffrey
openaire   +4 more sources

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2021–2022

open access: yesMass Spectrometry Reviews, Volume 44, Issue 3, Page 213-453, May/June 2025.
Abstract The use of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this review is the 12th update of the original article published in 1999 and brings coverage of the literature to the end of 2022.
David J. Harvey
wiley   +1 more source

Marinisporolides, Polyene-Polyol Macrolides from a Marine Actinomycete of the New Genus Marinispora

open access: yes, 2016
Two new polyene macrolides, marinisporolides A and B (1, 2), were isolated from the saline culture of the marine actinomycete, strain CNQ-140, identified as a member of the new marine genus Marinispora.
William Fenical (48035)   +3 more
core   +1 more source

The Significance of Mono‐ and Dual‐Effective Agents in the Development of New Antifungal Strategies

open access: yesChemical Biology &Drug Design, Volume 105, Issue 1, January 2025.
The future of treating challenging fungal infections lies in novel therapies targeting new antifungal targets, overcoming resistance mechanisms, and exploring innovative dual inhibitors. ABSTRACT Invasive fungal infections (IFIs) pose significant challenges in clinical settings, particularly due to their high morbidity and mortality rates.
Cengiz Zobi, Oztekin Algul
wiley   +1 more source

New Streptomyces‐Derived Antibacterial Compounds Targeting Gram‐Positive Bacteria: A Systematic Review

open access: yesThe Scientific World Journal, Volume 2025, Issue 1, 2025.
Bacterial infections, particularly those caused by Gram‐positive bacteria like vancomycin‐resistant enterococci (VRE) and methicillin‐resistant Staphylococcus aureus (MRSA), are a growing concern. This review highlights the potential of the Streptomyces genus in producing novel antibacterial compounds against Gram‐positive bacteria.
Soumia Ait Assou   +2 more
wiley   +1 more source

Comparing the activity and interactions of the antifungal protein PeAfpA with conventional fungicides and food preservatives against mycotoxigenic fungi

open access: yesInternational Journal of Food Science &Technology, Volume 59, Issue 12, Page 9326-9335, December 2024.
PeAfpA is an antifungal protein produced by Penicillium expansum. In this study, the activity of this protein was compared with fungicides (imazalil and thiabendazole) and preservatives (calcium propionate, sodium, sodium benzoate, potassium sorbate and natamycin). In addition, the effect of PeAfpA in combination with imazalil, thiabendazole, natamycin
Laura Hernández‐García   +4 more
wiley   +1 more source

Harnessing Plant Growth–Promoting and Wilt‐Controlling Biopotential of a Consortium of Actinomycetes and Mycorrhizae in Pigeon Pea

open access: yesJournal of Phytopathology, Volume 172, Issue 5, September/October 2024.
ABSTRACT Fusarium‐induced wilt significantly affects the cultivation and yield of pigeon peas. This warrants sustainable disease management while promoting plant growth. The present study investigated the biopotential of coinoculation of Streptomyces pseudogriseolus S‐9 and Rhizophagus irregularis for plant growth promotion and mitigation of the impact
Anand Dave   +5 more
wiley   +1 more source

Marine Macrolides: Blue Biotechnology Against Cancer

open access: yes, 2013
Chemical study of marine organisms has revealed them as a rich source of natural products with unique structural characteristics and outstanding biological activities.
Hernández Daranas, Antonio   +3 more
core   +1 more source

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