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Determining the optimal polyene antifungal dosing in obese patients is considered highly challenging. Limited data are available to describe the pharmacokinetics of polyene antifungals in these patients. However, polyene antifungals demonstrate widely variable pharmacokinetics in various clinical conditions.
Jamal, Janattul-Ain, Roberts, Jason A.
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Bifunctional Polyene Cyclizations: Synthetic Studies on Pimarane Natural Products
Polyene cyclizations generate molecular complexity from a linear polyene in a single step. While methods to initiate these cyclizations have been continuously expanded and improved over the years, the majority of polyene substrates are still limited to ...
Julian M Feilner +2 more
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We report on the formation of the field-effect transistor based on a polyyne–polyene structure. Polyvinylidene chloride (PVDC) drop casting and its subsequent dehydrochlorination in KOH solution allowed for the formation of porous polyyne&ndash ...
Oleg A Streletskiy +2 more
exaly +2 more sources
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Organic Letters, 2012
A microwave assisted Wittig reaction allowed the synthesis, in good yields, of the longest polyene so far recorded with 27 conjugated double bonds. The synthesis of this stable, well-soluble polyene represents a noteworthy step in the direction of ultimate λ(max).
Muhammad, Zeeshan +3 more
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A microwave assisted Wittig reaction allowed the synthesis, in good yields, of the longest polyene so far recorded with 27 conjugated double bonds. The synthesis of this stable, well-soluble polyene represents a noteworthy step in the direction of ultimate λ(max).
Muhammad, Zeeshan +3 more
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Enantioselective polyene cyclizations
Organic & Biomolecular Chemistry, 2016A comprehensive review covering the field of enantioselective polyene cyclizations.
Chad N, Ungarean +2 more
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Quantum interference in polyenes
The Journal of Chemical Physics, 2014The explicit form of the zeroth Green's function in the Hückel model, approximated by the negative of the inverse of the Hückel matrix, has direct quantum interference consequences for molecular conductance. We derive a set of rules for transmission between two electrodes attached to a polyene, when the molecule is extended by an even number of carbons
Yuta Tsuji +3 more
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Biomimetic studies on polyenes
Org. Biomol. Chem., 2003The crispatenes and SNF4435 C&D are complex polypropionate derived natural products. The core structures of these compounds along with a complex unnatural structure can be easily prepared from a common polyene precursor simply by variation of the reaction conditions.
John E, Moses +4 more
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Biomimetic polyene cyclizations
Bioorganic Chemistry, 1976AbstractCertain polyenic substances having trans olefinic bonds in a 1,5 relationship can be induced to undergo stereospecific, non‐enzymic, cationic cyclization to give polycyclic products with all‐trans (“natural”) configuration. These transformations appear to mimic in principle the biogenetic conversion of squalene into polycyclic triterpenoids ...
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The Polyene Antifungal Antibiotics
1963During the early 1950’s there appeared reports, from time to time of the presence among the products elaborated by actinomycetes of antifungal antibiotics which exhibited very similar and very characteristic multipeaked ultraviolet absorption spectra. In 1954, with a good number of examples on record, these spectra were analyzed and identified as those
W, OROSHNIK, A D, MEBANE
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