Results 171 to 180 of about 24,760 (225)
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2005
Polyene antibiotics (i.e., amphotericin B and nystatin) have been incorporated into lipid-based delivery systems to decrease their toxicity and enhance their therapeutic index, the most common being liposomes. This chapter describes the protocols for preparing liposomal amphotericin B and determining the efficacy and toxicity of the formulations in ...
Agatha W K, Ng +2 more
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Polyene antibiotics (i.e., amphotericin B and nystatin) have been incorporated into lipid-based delivery systems to decrease their toxicity and enhance their therapeutic index, the most common being liposomes. This chapter describes the protocols for preparing liposomal amphotericin B and determining the efficacy and toxicity of the formulations in ...
Agatha W K, Ng +2 more
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Biomimetic studies on polyenes
Org. Biomol. Chem., 2003The crispatenes and SNF4435 C&D are complex polypropionate derived natural products. The core structures of these compounds along with a complex unnatural structure can be easily prepared from a common polyene precursor simply by variation of the reaction conditions.
John E, Moses +4 more
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2016
Determining the optimal polyene antifungal dosing in obese patients is considered highly challenging. Limited data are available to describe the pharmacokinetics of polyene antifungals in these patients. However, polyene antifungals demonstrate widely variable pharmacokinetics in various clinical conditions.
Jamal, Janattul-Ain, Roberts, Jason A.
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Determining the optimal polyene antifungal dosing in obese patients is considered highly challenging. Limited data are available to describe the pharmacokinetics of polyene antifungals in these patients. However, polyene antifungals demonstrate widely variable pharmacokinetics in various clinical conditions.
Jamal, Janattul-Ain, Roberts, Jason A.
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Quantum interference in polyenes
The Journal of Chemical Physics, 2014The explicit form of the zeroth Green's function in the Hückel model, approximated by the negative of the inverse of the Hückel matrix, has direct quantum interference consequences for molecular conductance. We derive a set of rules for transmission between two electrodes attached to a polyene, when the molecule is extended by an even number of carbons
Yuta Tsuji +3 more
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Polyene Macrolide Antibiotic Biosynthesis
Current Medicinal Chemistry, 2004Polyenes constitute a large class of natural metabolites produced by giant multifunctional enzymes in a process resembling fatty acid biosynthesis. Like fatty acids, polyene macrolides and other polyketides are assembled by decarboxylative condensations of simple carboxylic acids.
J F, Aparicio +4 more
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Bio-inspired polyene cyclization: aziridinyl polyene cyclization catalyzed by InBr3
Chemical Communications, 2009This communication describes a highly efficient aziridinyl polyolefin cyclization catalyzed by InBr(3) to synthesize chiral terpenoid bearing a 3-amino group in the A ring; both good yields and excellent asymmetric induction were achieved.
Yu-Jun, Zhao +4 more
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The Polyene Antifungal Antibiotics
1963During the early 1950’s there appeared reports, from time to time of the presence among the products elaborated by actinomycetes of antifungal antibiotics which exhibited very similar and very characteristic multipeaked ultraviolet absorption spectra. In 1954, with a good number of examples on record, these spectra were analyzed and identified as those
W, OROSHNIK, A D, MEBANE
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Polyenic compounds Communication 2. Polyenic compounds containing heterocyclic substituents
Bulletin of the Academy of Sciences of the USSR Division of Chemical Science, 19561. In the reactions of 2-pyridylmethyllithium and of 2-quinolylmethyllithium with 3-methyl-6-phenyl-3, 5-hexadien-2-one, the corresponding tertiary alcohols were formed. Dehydration of these gave 2, 3-dimethyl-6-phenyl-1-(2-pyridyl)-1, 3, 5-hexatriene and 2, 3-dirnethyl-6-phenyl-1-(2-quinolyl)-1, 3, 5-hexatriene. 2.
B. M. Mikhailov, G. S. Ter-Sarkisyan
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Über einige neue Polyen‐diketone und Polyen‐diketo‐carbonsäuren
Helvetica Chimica Acta, 1954AbstractDurch Kondensation von Diacetyl mit Monoaldehyd‐fumarsäuremethylester und Muconsäure‐monoaldehyd‐monomethylester wurden verschiedene Polyen‐diketo‐carbonsäureester dargestellt und ihre UV.‐Absorptionsspektren verglichen.
G. Pictet, P. Karrer
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Polyenes Communication 5. Synthesis of unsymmetrical diaryl polyenic hydrocarbons
Bulletin of the Academy of Sciences of the USSR Division of Chemical Science, 19591. By the reaction of the Grignard reagent from α-chloro-p-xylene with polyethoxyphenylalkanes C6H5-[CH(OC2H5-CH2]n-CH(OC2H5)2 polyethoxyphenyl-p-tolylalkanes are formed: C6H5 -[CH(OC2H5)-CH2)]n+1 -C6H4-CH3-p 2. By the action of aqueous-alcoholic hydrogen bromide these are converted into phenyl-p-tolyl polyenes C6H5-(CH=CH)n+1−-C6H4-CH3 ...
B. M. Mikhailov, L. S. Povarov
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