Results 31 to 40 of about 3,978 (197)

Transcriptomic analysis of polyketide synthases in a highly ciguatoxic dinoflagellate, Gambierdiscus polynesiensis and low toxicity Gambierdiscus pacificus, from French Polynesia.

PLoS ONE, 2020
Marine dinoflagellates produce a diversity of polyketide toxins that are accumulated in marine food webs and are responsible for a variety of seafood poisonings.
Frances M Van Dolah, Jeanine S Morey, Shard Milne, André Ung, Paul E Anderson, Mireille Chinain   +5 more
doaj   +1 more source

Solid phase extraction for removal of matrix effects in lipophilic marine toxin analysis by liquid chromatography-tandem mass spectrometry [PDF]

, 2009
The potential of solid phase extraction (SPE) clean-up has been assessed to reduce matrix effects (signal suppression or enhancement) in the liquid chromatography-tandem mass spectrometry (LC¿MS/MS) analysis of lipophilic marine toxins.
A Furey, A Gerssen, Arjen Gerssen, C Moroney, CO Miles, CO Miles, DJA Richard, E Fux, E Fux, E Ito, European Commission, H Goto, H Toyofuku, J Alexander, Jacob de Boer, K Jorgensen, K Terao, L Puech, LA Stobo, MA Quilliam, MA Quilliam, Mairead A. McElhinney, MJ Twiner, P Hess, P McNabb, P Vale, Patrick P. J. Mulder, PF Puente, Philipp Hess, Ronel Bire, S Ito, T Aune, T Yasumoto   +32 more
core   +3 more sources

Alternative method to detect compounds produced by Gambierdiscus spp.

Frontiers in Marine Science, 2014
Ciguatoxins (CTXs) and CTX precursors are produced by several Gambierdiscus spp. These polyether toxins are associated to ciguatera fish poisoning (CFP). In addition to CTX, maitotoxins (MTX) and gambierol are also produced by these dinoflagellates.
Jon Andoni Sánchez
doaj   +1 more source

The development of endo-selective epoxide-opening cascades in water [PDF]

, 2009
This tutorial review traces the development of endo-regioselective epoxide-opening reactions in water. Templated, water-promoted epoxide-opening cyclization reactions can offer rapid access to subunits of the ladder polyethers, a fascinating and complex ...
Byers, Jeffery A., Jamison, Timothy F., Morten, Christopher J., Van Dyke, Aaron R., Vilotijevic, Ivan   +4 more
core   +1 more source

Polyether toxin analysis of the top minnow(Poecilia vitatta)

Food and Agricultural Immunology, 1993
A detailed toxicity analysis was performed on the top minnow utilizing the stick‐enzyme immunoassay (S‐EIA), the mouse bioassay, the guinea pig atrium assay and fluorometric HPLC. The S‐EIA test indicated 96% of the samples tested contained polyether toxins. Mice injected with acetone extractions from top minnow displayed symptoms of toxicity while the
E. Titus, K. Katsura, J. T. Miyahara, Y. Hokama   +3 more
openaire   +1 more source

Ciguatoxins: Cyclic Polyether Modulators of Voltage-gated Iion Channel Function

Marine Drugs, 2006
Ciguatoxins are cyclic polyether toxins, derived from marine dinoflagellates, which are responsible for the symptoms of ciguatera poisoning. Ingestion of tropical and subtropical fin fish contaminated by ciguatoxins results in an illness characterised by
Richard J. Lewis, Graham M. Nicholson
doaj   +1 more source

Friends or Foes? Emerging Impacts of Biological Toxins [PDF]

, 2019
Toxins are substances produced from biological sources (e.g., animal, plants, microorganisms) that have deleterious effects on a living organism. Despite the obvious health concerns of being exposed to toxins, they are having substantial positive impacts
Casewell, N.R., Clark, G.C., Elliott, C.T., Harvey, A.L., Jamieson, A.G., Strong, Peter, Turner, A.D.   +6 more
core   +6 more sources

Spider neurotoxins targeting voltage-gated sodium channels [PDF]

, 2005
The voltage-gated sodium (Nav) channel is a target for a number of drugs, insecticides, and neurotoxins. These bind to at least seven identified neurotoxin binding sites and either block conductance or modulate sodium channel gating and/or kinetics.
Little, MJ, Nicholson, GM
core   +1 more source

The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state [PDF]

Journal of General Physiology, 2013
Voltage-gated potassium (Kv) and sodium (Nav) channels are key determinants of cellular excitability and serve as targets of neurotoxins. Most marine ciguatoxins potentiate Nav channels and cause ciguatera seafood poisoning. Several ciguatoxins have also been shown to affect Kv channels, and we showed previously that the ladder-shaped polyether toxin ...
Kopljar, Ivan, Labro, Alain J, de Block, Tessa, Rainier, Jon D., Tytgat, Jan, Snyders, Dirk J.   +5 more
openaire   +4 more sources

Modulus‐Switchable Miniature Robots for Biomedical Applications: A Review

Advanced Robotics Research, EarlyView.
Materials, robot designs, proof‐of‐concept functions, and biomedical applications of modulus‐switchable miniature robots. Miniature soft robots have shown great potential in biomedical applications due to their excellent controllability and suitable mechanical properties in biological environments.
Chunyun Wei, Yibin Wang, Jiangfan Yu
wiley   +1 more source